Journal ArticleDOI
Child developmental risk-factors for adult schizophrenia in the british 1946 birth cohort
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TLDR
Differences between children destined to develop schizophrenia as adults and the general population were found across a range of developmental domains, and the origins of schizophrenia may be found in early life.About:
This article is published in The Lancet.The article was published on 1994-11-19. It has received 1326 citations till now. The article focuses on the topics: Cohort study & Odds ratio.read more
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Risk factors for onset and persistence of psychosis.
TL;DR: Evidence supporting the validity of a model of shared risk factors for continuous characteristics needs to be further elaborated and incorporated into the concepts of psychotic illness.
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Schizophrenia
TL;DR: Schizophrenia, characterised by psychotic symptoms and in many cases social and occupational decline, remains an aetiological and therapeutic challenge as mentioned in this paper , and the mainstay of treatment remains dopamine receptor blocking drugs; a psychological intervention, cognitive behavioural therapy, has relatively small effects on symptoms.
Journal ArticleDOI
Intrinsic Hippocampal Activity as a Biomarker for Cognition and Symptoms in Schizophrenia
Jason R. Tregellas,Jason Smucny,Josette G. Harris,Ann Olincy,Keeran Maharajh,Eugene Kronberg,Lindsay C. Eichman,Emma Lyons,Robert Freedman +8 more
TL;DR: Findings suggest that greater intrinsic hippocampal activity is a characteristic feature of schizophrenia that is broadly associated with cognitive dysfunction, and they support hippocampusal activity as a candidate biomarker for therapeutic development.
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Polygenic Risk for Schizophrenia Is Associated with Cognitive Change Between Childhood and Old Age
Andrew M. McIntosh,Alan J. Gow,Michelle Luciano,Gail Davies,David C. Liewald,Sarah E. Harris,Janie Corley,Jeremy Hall,John M. Starr,David J. Porteous,Albert Tenesa,Peter M. Visscher,Ian J. Deary +12 more
TL;DR: Increased polygenic risk of schizophrenia is associated with lower cognitive ability at age 70 and greater relative decline in general cognitive ability between the ages of 11 and 70.
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Peri-pubertal maturation after developmental disturbance: A model for psychosis onset in the rat
TL;DR: This study confirms that transient prenatal disruption of neurogenesis by MAM at E17 is a valid behavioral model for schizophrenia as it is able to reproduce some fundamental features of schizophrenia with respect to both phenomenology and temporal pattern of the onset of symptoms and deficits.
References
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Journal ArticleDOI
Implications of normal brain development for the pathogenesis of schizophrenia
TL;DR: The findings suggest that nonspecific histopathology exists in the limbic system, diencephalon, and prefrontal cortex, that the pathology occurs early in development, and that the causative process is inactive long before the diagnosis is made.
Book
The strategy of preventive medicine
TL;DR: This chapter discusses the relation of risk to exposure, prevention for individuals and the 'high-risk' strategy, and the population strategy of prevention.
Journal ArticleDOI
Adult Schizophrenia Following Prenatal Exposure to an Influenza Epidemic
TL;DR: It is suggested that it is less the type than the timing of the disturbance during fetal neural development that is critical in determining risk for schizophrenia.
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Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia.
Richard L. Suddath,George W. Christison,E. Fuller Torrey,Manuel F. Casanova,Daniel R. Weinberger +4 more
TL;DR: In this article, the authors found that subtle abnormalities of cerebral anatomy (namely, small anterior hippocampi and enlarged lateral and third ventricles) are consistent neuropathologic features of schizophrenia and that their cause is at least in part not genetic.
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Is schizophrenia a neurodevelopmental disorder
Robin M. Murray,Shôn Lewis +1 more
TL;DR: Much research implicates the left rather than the right cerebral hemisphere in schizophrenia, and there is evidence that schizophrenics are more likely to be left handed than controls, and the normal development of lateralised cerebral dominance can be disrupted by premature birth with a resultant increase in left handedness.