Journal ArticleDOI
Child developmental risk-factors for adult schizophrenia in the british 1946 birth cohort
TLDR
Differences between children destined to develop schizophrenia as adults and the general population were found across a range of developmental domains, and the origins of schizophrenia may be found in early life.About:
This article is published in The Lancet.The article was published on 1994-11-19. It has received 1326 citations till now. The article focuses on the topics: Cohort study & Odds ratio.read more
Citations
More filters
Journal ArticleDOI
The Epidemiology of First-Episode Psychosis in Early Intervention in Psychosis Services: Findings From the Social Epidemiology of Psychoses in East Anglia [SEPEA] Study.
James B. Kirkbride,Yasir Hameed,Gayatri Ankireddypalli,Konstantinos Ioannidis,Carolyn M Crane,Mukhtar Nasir,Nikolett Kabacs,Antonio Metastasio,Oliver Jenkins,Ashkan Espandian,Styliani Spyridi,Danica Ralevic,Suneetha Siddabattuni,Ben Walden,Adewale Adeoye,Jesus Perez,Peter B. Jones +16 more
TL;DR: Pronounced variation in psychosis incidence, peaking before 20 years old, exists in populations served by early intervention psychosis services, suggesting that a threshold of socioenvironmental adversity may be necessary to increase incidence.
Journal ArticleDOI
Patterns of premorbid functioning in first-episode psychosis: initial presentation.
TL;DR: These results suggest that prior to the onset of the acute psychosis those who have poor social and interpersonal functioning premorbidly present initially with increased social impairment and negative symptoms compared to those who has better premor bid functioning.
Journal ArticleDOI
A prospective twin study of birth weight discordance and child problem behavior.
Jim van Os,Marieke Wichers,Marina Danckaerts,Sofie Van Gestel,Catherine Derom,Robert Vlietinck +5 more
TL;DR: The fact that the effect size of the association between low birth weight and child problem behavior was not reduced in pairs with greater levels of CBCL discordance, and similar effect sizes were found in monozygotic and dizygotic twins for the within-pair association between birth weight discordance and CBCL score discordance suggests that the observed relationship is not due to a shared environmental or genetic variable that influences both characteristics.
Journal ArticleDOI
Cognitive development prior to onset of psychosis.
TL;DR: An overview of population-based studies on premorbid cognitive deficits in schizophrenia is given, with a special focus on evidence regarding the specificity, profile and course of these deficits.
Journal ArticleDOI
Association between psychotic disorder and urban place of birth is not mediated by obstetric complications or childhood socio-economic position: a cohort study.
TL;DR: Urbanization of birthplace is associated with increased risk of non-affective psychosis but this is not confined to narrowly defined cases and the magnitude of the association in Sweden is lower than that reported in other studies.
References
More filters
Journal ArticleDOI
Implications of normal brain development for the pathogenesis of schizophrenia
TL;DR: The findings suggest that nonspecific histopathology exists in the limbic system, diencephalon, and prefrontal cortex, that the pathology occurs early in development, and that the causative process is inactive long before the diagnosis is made.
Book
The strategy of preventive medicine
TL;DR: This chapter discusses the relation of risk to exposure, prevention for individuals and the 'high-risk' strategy, and the population strategy of prevention.
Journal ArticleDOI
Adult Schizophrenia Following Prenatal Exposure to an Influenza Epidemic
TL;DR: It is suggested that it is less the type than the timing of the disturbance during fetal neural development that is critical in determining risk for schizophrenia.
Journal ArticleDOI
Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia.
Richard L. Suddath,George W. Christison,E. Fuller Torrey,Manuel F. Casanova,Daniel R. Weinberger +4 more
TL;DR: In this article, the authors found that subtle abnormalities of cerebral anatomy (namely, small anterior hippocampi and enlarged lateral and third ventricles) are consistent neuropathologic features of schizophrenia and that their cause is at least in part not genetic.
Journal ArticleDOI
Is schizophrenia a neurodevelopmental disorder
Robin M. Murray,Shôn Lewis +1 more
TL;DR: Much research implicates the left rather than the right cerebral hemisphere in schizophrenia, and there is evidence that schizophrenics are more likely to be left handed than controls, and the normal development of lateralised cerebral dominance can be disrupted by premature birth with a resultant increase in left handedness.