Journal ArticleDOI
Child developmental risk-factors for adult schizophrenia in the british 1946 birth cohort
TLDR
Differences between children destined to develop schizophrenia as adults and the general population were found across a range of developmental domains, and the origins of schizophrenia may be found in early life.About:
This article is published in The Lancet.The article was published on 1994-11-19. It has received 1326 citations till now. The article focuses on the topics: Cohort study & Odds ratio.read more
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Is schizophrenia a neurodegenerative disorder? A clinical and neurobiological perspective.
TL;DR: It is suggested that the rejection of a role for neurodegeneration in the pathophysiology of schizophrenia is unproven and may be premature, and a wholly neurodevelopmental perspective of the illness imbues the illness with a pessimistic inevitability and therapeutic nihilism that may be unwarranted.
Journal ArticleDOI
Epidemiology of schizophrenia: the global burden of disease and disability.
TL;DR: The emerging pattern of risk factors and antecedents of schizophrenia suggests multiple, mainly quantitative deviations from the average developmental trajectory, primarily in the areas of early neurodevelopment, cognitive ability and social behaviour, compatible with the notion of non-specific background factors facilitating the operation of genetically determined causal pathways.
Journal ArticleDOI
Cognitive Control Deficits in Schizophrenia: Mechanisms and Meaning
TL;DR: This model provides a theoretical link between cellular abnormalities, functional disturbances in local circuit function, altered inter-regional cortical connectivity, and symptom presentation in the disorder and discusses recent advances in the neuropharmacology of cognition.
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Negative Symptoms and Cognitive Deficits: What Is the Nature of Their Relationship?
Philip D. Harvey,Danny Koren,Danny Koren,Abraham Reichenberg,Christopher R. Bowie,Christopher R. Bowie +5 more
TL;DR: It is concluded that negative and cognitive symptoms may be separable, if not conceptually independent, domains of the illness and that it might be possible to develop treatments that target negative symptoms and cognitive deficits independently.
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Sexual and physical abuse during childhood and adulthood as predictors of hallucinations, delusions and thought disorder.
TL;DR: Investigation of the hypotheses that childhood sexual and physical abuse are related to hallucinations, delusions, and thought disorder in adults and that those relationships are greater in those who have suffered abuse during adulthood as well as childhood found that child abuse was a significant predictor of auditory and tactile hallucinations, even in the absence of adult abuse.
References
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Journal ArticleDOI
Implications of normal brain development for the pathogenesis of schizophrenia
TL;DR: The findings suggest that nonspecific histopathology exists in the limbic system, diencephalon, and prefrontal cortex, that the pathology occurs early in development, and that the causative process is inactive long before the diagnosis is made.
Book
The strategy of preventive medicine
TL;DR: This chapter discusses the relation of risk to exposure, prevention for individuals and the 'high-risk' strategy, and the population strategy of prevention.
Journal ArticleDOI
Adult Schizophrenia Following Prenatal Exposure to an Influenza Epidemic
TL;DR: It is suggested that it is less the type than the timing of the disturbance during fetal neural development that is critical in determining risk for schizophrenia.
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Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia.
Richard L. Suddath,George W. Christison,E. Fuller Torrey,Manuel F. Casanova,Daniel R. Weinberger +4 more
TL;DR: In this article, the authors found that subtle abnormalities of cerebral anatomy (namely, small anterior hippocampi and enlarged lateral and third ventricles) are consistent neuropathologic features of schizophrenia and that their cause is at least in part not genetic.
Journal ArticleDOI
Is schizophrenia a neurodevelopmental disorder
Robin M. Murray,Shôn Lewis +1 more
TL;DR: Much research implicates the left rather than the right cerebral hemisphere in schizophrenia, and there is evidence that schizophrenics are more likely to be left handed than controls, and the normal development of lateralised cerebral dominance can be disrupted by premature birth with a resultant increase in left handedness.