Journal ArticleDOI
Child developmental risk-factors for adult schizophrenia in the british 1946 birth cohort
TLDR
Differences between children destined to develop schizophrenia as adults and the general population were found across a range of developmental domains, and the origins of schizophrenia may be found in early life.About:
This article is published in The Lancet.The article was published on 1994-11-19. It has received 1326 citations till now. The article focuses on the topics: Cohort study & Odds ratio.read more
Citations
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Journal ArticleDOI
Differential patterns of premorbid academic and social deterioration in patients with schizophrenia.
Daniel N. Allen,Linda V. Frantom,Gregory P. Strauss,Daniel P. van Kammen,Daniel P. van Kammen +4 more
TL;DR: Investigation of academic and social functioning prior to schizophrenia onset in a group of 58 males diagnosed with schizophrenia suggests that premorbid academic functioning is particularly susceptible to deterioration during late adolescence, with accelerating deterioration as schizophrenia onset becomes imminent.
Journal ArticleDOI
Cognitive deficits and the neurobiology of schizophrenia
TL;DR: A network of connected frontal-temporal-limbic structures in patients' brain structure, cognitive function, and physiology is demonstrated and it is concluded that these abnormalities are most probably developmental in origin.
Journal ArticleDOI
School Performance as a Premorbid Marker for Schizophrenia: A Twin Study
TL;DR: In both MZ and DZ twin pairs with schizophrenia, divergence in school performance occurred about 7.5 years earlier than it did in control twins, at 12 years of age, preceding the onset of psychosis by 10 years, suggesting that the first prodromal signs of schizophrenia manifest themselves as cognitive symptoms atThe onset of puberty.
Journal ArticleDOI
Behavioral changes in rats with early ventral hippocampal damage vary with age at damage.
TL;DR: The results indicate that the pattern of impairments associated with the excitotoxic VH lesion varies with age at lesion, i.e. a similar pattern seems to be associated with lesions up to PD7, but not by PD14.
Book
Schizophrenia in Children and Adolescents
TL;DR: The prevalence of very early-onset schizophrenia (below age 13) is about 2 in a million children in the genera.
References
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Journal ArticleDOI
Implications of normal brain development for the pathogenesis of schizophrenia
TL;DR: The findings suggest that nonspecific histopathology exists in the limbic system, diencephalon, and prefrontal cortex, that the pathology occurs early in development, and that the causative process is inactive long before the diagnosis is made.
Book
The strategy of preventive medicine
TL;DR: This chapter discusses the relation of risk to exposure, prevention for individuals and the 'high-risk' strategy, and the population strategy of prevention.
Journal ArticleDOI
Adult Schizophrenia Following Prenatal Exposure to an Influenza Epidemic
TL;DR: It is suggested that it is less the type than the timing of the disturbance during fetal neural development that is critical in determining risk for schizophrenia.
Journal ArticleDOI
Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia.
Richard L. Suddath,George W. Christison,E. Fuller Torrey,Manuel F. Casanova,Daniel R. Weinberger +4 more
TL;DR: In this article, the authors found that subtle abnormalities of cerebral anatomy (namely, small anterior hippocampi and enlarged lateral and third ventricles) are consistent neuropathologic features of schizophrenia and that their cause is at least in part not genetic.
Journal ArticleDOI
Is schizophrenia a neurodevelopmental disorder
Robin M. Murray,Shôn Lewis +1 more
TL;DR: Much research implicates the left rather than the right cerebral hemisphere in schizophrenia, and there is evidence that schizophrenics are more likely to be left handed than controls, and the normal development of lateralised cerebral dominance can be disrupted by premature birth with a resultant increase in left handedness.