Journal ArticleDOI
Child developmental risk-factors for adult schizophrenia in the british 1946 birth cohort
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TLDR
Differences between children destined to develop schizophrenia as adults and the general population were found across a range of developmental domains, and the origins of schizophrenia may be found in early life.About:
This article is published in The Lancet.The article was published on 1994-11-19. It has received 1326 citations till now. The article focuses on the topics: Cohort study & Odds ratio.read more
Citations
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Deficits in the identification of pleasant odors predict the transition of an at-risk mental state to psychosis
Magdalena Kotlicka-Antczak,Agnieszka Pawełczyk,Michał Seweryn Karbownik,Tomasz Pawełczyk,Dominik Strzelecki,Natalia Żurner,Małgorzata Urban-Kowalczyk +6 more
TL;DR: The findings imply that the impaired identification of pleasant odorants may be a risk factor for the transition of an ARMS into a psychotic disorder, and highlights the need for further research of OI in "at-risk" cohorts, taking into account the hedonic attributes of odors.
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Associations between early development and outcome in schizophrenia--A 35-year follow-up of the Northern Finland 1966 Birth Cohort.
Erika Jääskeläinen,Jouko Miettunen,Jouko Miettunen,Juha Veijola,Juha Veijola,John J. McGrath,Graham K. Murray,Peter B. Jones,Matti Isohanni +8 more
TL;DR: It is concluded that risk factors for schizophrenia are not necessarily prognostic factors and later attainment of developmental milestones was not associated with poor outcome.
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Neurodevelopmental liabilities in schizophrenia and affective disorders
TL;DR: There is now considerable evidence that both schizophrenia and affective disorders have their origin at least in part in events that occur during early pre-and post-natal development as discussed by the authors, suggesting that a second trimester insult may have occurred and may have increased the risk for the development of schizophrenia in late adolescence or early adulthood.
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Placental genomic risk scores and early neurodevelopmental outcomes
Gianluca Ursini,Giovanna Punzi,Benjamin Langworthy,Qiang Chen,Kai Xia,Emil Cornea,Barbara D. Goldman,Martin Styner,Rebecca C. Knickmeyer,John H. Gilmore,Daniel R. Weinberger +10 more
TL;DR: Ursini et al. as mentioned in this paper analyzed whether fractionated genomic risk scores for schizophrenia and other developmental disorders and traits, based on placental gene-expression loci (PlacGRSss), are linked with early neurodevelopmental outcomes in individuals with a history of ELCs.
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Child literacy and psychotic experiences in early adolescence : findings from the ALSPAC study
TL;DR: A lower performance in all measurements of child literacy skills in those with suspected or definite PEs is found, Relative to the group unaffected by PEs, and both a consistently low pattern of performance and a decline were associated with suspected OR PEs.
References
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Journal ArticleDOI
Implications of normal brain development for the pathogenesis of schizophrenia
TL;DR: The findings suggest that nonspecific histopathology exists in the limbic system, diencephalon, and prefrontal cortex, that the pathology occurs early in development, and that the causative process is inactive long before the diagnosis is made.
Book
The strategy of preventive medicine
TL;DR: This chapter discusses the relation of risk to exposure, prevention for individuals and the 'high-risk' strategy, and the population strategy of prevention.
Journal ArticleDOI
Adult Schizophrenia Following Prenatal Exposure to an Influenza Epidemic
TL;DR: It is suggested that it is less the type than the timing of the disturbance during fetal neural development that is critical in determining risk for schizophrenia.
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Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia.
Richard L. Suddath,George W. Christison,E. Fuller Torrey,Manuel F. Casanova,Daniel R. Weinberger +4 more
TL;DR: In this article, the authors found that subtle abnormalities of cerebral anatomy (namely, small anterior hippocampi and enlarged lateral and third ventricles) are consistent neuropathologic features of schizophrenia and that their cause is at least in part not genetic.
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Is schizophrenia a neurodevelopmental disorder
Robin M. Murray,Shôn Lewis +1 more
TL;DR: Much research implicates the left rather than the right cerebral hemisphere in schizophrenia, and there is evidence that schizophrenics are more likely to be left handed than controls, and the normal development of lateralised cerebral dominance can be disrupted by premature birth with a resultant increase in left handedness.