Journal ArticleDOI
Child developmental risk-factors for adult schizophrenia in the british 1946 birth cohort
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Differences between children destined to develop schizophrenia as adults and the general population were found across a range of developmental domains, and the origins of schizophrenia may be found in early life.About:
This article is published in The Lancet.The article was published on 1994-11-19. It has received 1326 citations till now. The article focuses on the topics: Cohort study & Odds ratio.read more
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Etiological and clinical features of childhood psychotic symptoms: results from a birth cohort.
Guilherme V. Polanczyk,Terrie E. Moffitt,Louise Arseneault,Mary Cannon,Antony Ambler,Richard S.E. Keefe,Renate Houts,Candice L. Odgers,Avshalom Caspi +8 more
TL;DR: The results indicate that children who have psychotic symptoms can be recruited for neuroscience research to determine the pathogenesis of schizophrenia and indicate that psychotic symptoms in childhood are often a marker of an impaired developmental process and should be actively assessed.
Journal ArticleDOI
The life course prospective design: an example of benefits and problems associated with study longevity.
Michael E. J. Wadsworth,Suzanne Butterworth,Rebecca Hardy,Diana Kuh,Marcus Richards,Claudia Langenberg,WS Hilder,M Connor +7 more
TL;DR: Although the problems inherent in the prospective design are unavoidable they are not, in the study described, a barrier to scientific and policy value and that seems also likely in Britain's two later born national birth cohort studies that have continued into adulthood.
Journal ArticleDOI
Social functioning in individuals at clinical high risk for psychosis
TL;DR: It is demonstrated that even at the pre-psychotic phase of the illness, these young people are demonstrating significant deficits in social functioning, supporting that social deficits are present long before the onset of psychotic symptoms.
Journal ArticleDOI
22q11 Deletion Syndrome in Adults With Schizophrenia
TL;DR: The results replicate the association of a 22q11 deletion syndrome with schizophrenia and confirm the importance of ascertainment in influencing the phenotype found, which may include significant behavioral components that emerge over time.
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Childhood Cognitive Functioning in Schizophrenia Patients and Their Unaffected Siblings: A Prospective Cohort Study
Tyrone D. Cannon,Carrie E. Bearden,Hollister Jm,Isabelle M. Rosso,Sanchez Le,Trevor R. Hadley +5 more
TL;DR: During the period from age 4 to age 7 years, premorbid cognitive dysfunction in schizophrenia represents a relatively stable indicator of vulnerability deriving from primarily genetic (and/or shared environmental) etiologic influences.
References
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Journal ArticleDOI
Implications of normal brain development for the pathogenesis of schizophrenia
TL;DR: The findings suggest that nonspecific histopathology exists in the limbic system, diencephalon, and prefrontal cortex, that the pathology occurs early in development, and that the causative process is inactive long before the diagnosis is made.
Book
The strategy of preventive medicine
TL;DR: This chapter discusses the relation of risk to exposure, prevention for individuals and the 'high-risk' strategy, and the population strategy of prevention.
Journal ArticleDOI
Adult Schizophrenia Following Prenatal Exposure to an Influenza Epidemic
TL;DR: It is suggested that it is less the type than the timing of the disturbance during fetal neural development that is critical in determining risk for schizophrenia.
Journal ArticleDOI
Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia.
Richard L. Suddath,George W. Christison,E. Fuller Torrey,Manuel F. Casanova,Daniel R. Weinberger +4 more
TL;DR: In this article, the authors found that subtle abnormalities of cerebral anatomy (namely, small anterior hippocampi and enlarged lateral and third ventricles) are consistent neuropathologic features of schizophrenia and that their cause is at least in part not genetic.
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Is schizophrenia a neurodevelopmental disorder
Robin M. Murray,Shôn Lewis +1 more
TL;DR: Much research implicates the left rather than the right cerebral hemisphere in schizophrenia, and there is evidence that schizophrenics are more likely to be left handed than controls, and the normal development of lateralised cerebral dominance can be disrupted by premature birth with a resultant increase in left handedness.