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Journal ArticleDOI

Child developmental risk-factors for adult schizophrenia in the british 1946 birth cohort

Peter B. Jones, +3 more
- 19 Nov 1994 - 
- Vol. 344, Iss: 8934, pp 1398-1402
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TLDR
Differences between children destined to develop schizophrenia as adults and the general population were found across a range of developmental domains, and the origins of schizophrenia may be found in early life.
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This article is published in The Lancet.The article was published on 1994-11-19. It has received 1326 citations till now. The article focuses on the topics: Cohort study & Odds ratio.

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Citations
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Medial temporal lobe in childhood-onset schizophrenia

TL;DR: The amygdala was significantly larger in the schizophrenics than in the control subjects, and this volume increase was more pronounced on the left side, which is consistent with previous reports of at least initial sparing of temporal lobe regions in childhood-onset schizophrenia.
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Links Between Creativity and Mental Disorder

TL;DR: Evidence exists to support some form of association between creativity and mental disorder, but the direction of any causal link remains obscure.
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Risk factors, pre-morbid functioning and episode correlates of neurological soft signs in drug-naive patients with schizophrenia-spectrum disorders.

TL;DR: Familial liability to schizophrenia, obstetric complications, neurodevelopmental delay, deterioration in pre-morbid functioning and observable motor disorders appear to contribute independently to domains of neurological dysfunction.
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Toward a world consensus on prevention of schizophrenia.

TL;DR: The epidemiologically and ethically most viable way for screening and early detection is to selectively increase the permeability of the filters on the pathway to mental health care.
References
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Journal ArticleDOI

Implications of normal brain development for the pathogenesis of schizophrenia

TL;DR: The findings suggest that nonspecific histopathology exists in the limbic system, diencephalon, and prefrontal cortex, that the pathology occurs early in development, and that the causative process is inactive long before the diagnosis is made.
Book

The strategy of preventive medicine

Geoffrey Rose
TL;DR: This chapter discusses the relation of risk to exposure, prevention for individuals and the 'high-risk' strategy, and the population strategy of prevention.
Journal ArticleDOI

Adult Schizophrenia Following Prenatal Exposure to an Influenza Epidemic

TL;DR: It is suggested that it is less the type than the timing of the disturbance during fetal neural development that is critical in determining risk for schizophrenia.
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Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia.

TL;DR: In this article, the authors found that subtle abnormalities of cerebral anatomy (namely, small anterior hippocampi and enlarged lateral and third ventricles) are consistent neuropathologic features of schizophrenia and that their cause is at least in part not genetic.
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Is schizophrenia a neurodevelopmental disorder

Robin M. Murray, +1 more
- 19 Sep 1987 - 
TL;DR: Much research implicates the left rather than the right cerebral hemisphere in schizophrenia, and there is evidence that schizophrenics are more likely to be left handed than controls, and the normal development of lateralised cerebral dominance can be disrupted by premature birth with a resultant increase in left handedness.
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