Journal ArticleDOI
Child developmental risk-factors for adult schizophrenia in the british 1946 birth cohort
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Differences between children destined to develop schizophrenia as adults and the general population were found across a range of developmental domains, and the origins of schizophrenia may be found in early life.About:
This article is published in The Lancet.The article was published on 1994-11-19. It has received 1326 citations till now. The article focuses on the topics: Cohort study & Odds ratio.read more
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Medial temporal lobe in childhood-onset schizophrenia
Jennifer G. Levitt,Rebecca E. Blanton,Rochelle Caplan,Robert F. Asarnow,Robert F. Asarnow,Donald Guthrie,Arthur W. Toga,Linda Capetillo-Cunliffe,James T. McCracken +8 more
TL;DR: The amygdala was significantly larger in the schizophrenics than in the control subjects, and this volume increase was more pronounced on the left side, which is consistent with previous reports of at least initial sparing of temporal lobe regions in childhood-onset schizophrenia.
Journal ArticleDOI
Links Between Creativity and Mental Disorder
TL;DR: Evidence exists to support some form of association between creativity and mental disorder, but the direction of any causal link remains obscure.
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Childhood maltreatment and transition to psychotic disorder independently predict long-term functioning in young people at ultra-high risk for psychosis
Alison R. Yung,Jack Cotter,Stephen J. Wood,Patrick D. McGorry,Andrew Thompson,Barnaby Nelson,Ashleigh Lin +6 more
TL;DR: The finding that transition to psychosis predicts poor long-term functioning strengthens the evidence that the UHR criteria detect a subgroup at risk for schizophrenia.
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Risk factors, pre-morbid functioning and episode correlates of neurological soft signs in drug-naive patients with schizophrenia-spectrum disorders.
V. Peralta,E. G. de Jalón,Maria S. Campos,Virginia Basterra,Ana M. Sánchez-Torres,Manuel J. Cuesta +5 more
TL;DR: Familial liability to schizophrenia, obstetric complications, neurodevelopmental delay, deterioration in pre-morbid functioning and observable motor disorders appear to contribute independently to domains of neurological dysfunction.
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Toward a world consensus on prevention of schizophrenia.
Jim van Os,Philippe Delespaul +1 more
TL;DR: The epidemiologically and ethically most viable way for screening and early detection is to selectively increase the permeability of the filters on the pathway to mental health care.
References
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Journal ArticleDOI
Implications of normal brain development for the pathogenesis of schizophrenia
TL;DR: The findings suggest that nonspecific histopathology exists in the limbic system, diencephalon, and prefrontal cortex, that the pathology occurs early in development, and that the causative process is inactive long before the diagnosis is made.
Book
The strategy of preventive medicine
TL;DR: This chapter discusses the relation of risk to exposure, prevention for individuals and the 'high-risk' strategy, and the population strategy of prevention.
Journal ArticleDOI
Adult Schizophrenia Following Prenatal Exposure to an Influenza Epidemic
TL;DR: It is suggested that it is less the type than the timing of the disturbance during fetal neural development that is critical in determining risk for schizophrenia.
Journal ArticleDOI
Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia.
Richard L. Suddath,George W. Christison,E. Fuller Torrey,Manuel F. Casanova,Daniel R. Weinberger +4 more
TL;DR: In this article, the authors found that subtle abnormalities of cerebral anatomy (namely, small anterior hippocampi and enlarged lateral and third ventricles) are consistent neuropathologic features of schizophrenia and that their cause is at least in part not genetic.
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Is schizophrenia a neurodevelopmental disorder
Robin M. Murray,Shôn Lewis +1 more
TL;DR: Much research implicates the left rather than the right cerebral hemisphere in schizophrenia, and there is evidence that schizophrenics are more likely to be left handed than controls, and the normal development of lateralised cerebral dominance can be disrupted by premature birth with a resultant increase in left handedness.