Journal ArticleDOI
Child developmental risk-factors for adult schizophrenia in the british 1946 birth cohort
Reads0
Chats0
TLDR
Differences between children destined to develop schizophrenia as adults and the general population were found across a range of developmental domains, and the origins of schizophrenia may be found in early life.About:
This article is published in The Lancet.The article was published on 1994-11-19. It has received 1326 citations till now. The article focuses on the topics: Cohort study & Odds ratio.read more
Citations
More filters
Journal ArticleDOI
The relationship between predisposing factors, premorbid function and symptom dimensions in psychosis: an integrated approach.
Almudena Guerra,Paul Fearon,Pak C. Sham,Peter G. Jones,Shôn Lewis,Ignacio Mata,Robin M. Murray +6 more
TL;DR: The most striking finding was that disorganisation appeared to arise when a familial predisposition to mania was compounded by low premorbid IQ.
Journal ArticleDOI
Sustained attention and working memory deficits follow a familial pattern in schizophrenia.
TL;DR: This study assessed the familial pattern of deficits in sustained attention, working memory and executive function in remitted-schizophrenia patients and their unaffected siblings to support sustained attention and working memory deficits as potential endophenotypes of schizophrenia.
Book ChapterDOI
Schizophrenia and migration
TL;DR: Although a large number of factors have been proposed to play a role in the etiology of schizophrenia, no single environmental factor has yet been established with compelling certainty and there may be no room for environmental risk factors in current explanatory models.
Journal ArticleDOI
An Overview of Cognitive Remediation Therapy for People with Severe Mental Illness
TL;DR: Cognitive remediation refers to nonpharmacological methods of improving cognitive function in people with severe mental disorders, and has been shown to be effective, especially if combined with vocational rehabilitation.
Journal ArticleDOI
Electrophysiological Evidence for Impaired Control of Motor Output in Schizophrenia.
Emily S. Kappenman,Steven J. Luck,Ann M. Kring,Tyler A. Lesh,George R. Mangun,Tara A. Niendam,J. Daniel Ragland,Charan Ranganath,Marjorie Solomon,Tamara Y. Swaab,Cameron S. Carter +10 more
TL;DR: Behavioral measures and event-related potentials and ERP measures indicate that impairment in the ability to exert control over response-related processing may underlie response- related deficits in schizophrenia.
References
More filters
Journal ArticleDOI
Implications of normal brain development for the pathogenesis of schizophrenia
TL;DR: The findings suggest that nonspecific histopathology exists in the limbic system, diencephalon, and prefrontal cortex, that the pathology occurs early in development, and that the causative process is inactive long before the diagnosis is made.
Book
The strategy of preventive medicine
TL;DR: This chapter discusses the relation of risk to exposure, prevention for individuals and the 'high-risk' strategy, and the population strategy of prevention.
Journal ArticleDOI
Adult Schizophrenia Following Prenatal Exposure to an Influenza Epidemic
TL;DR: It is suggested that it is less the type than the timing of the disturbance during fetal neural development that is critical in determining risk for schizophrenia.
Journal ArticleDOI
Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia.
Richard L. Suddath,George W. Christison,E. Fuller Torrey,Manuel F. Casanova,Daniel R. Weinberger +4 more
TL;DR: In this article, the authors found that subtle abnormalities of cerebral anatomy (namely, small anterior hippocampi and enlarged lateral and third ventricles) are consistent neuropathologic features of schizophrenia and that their cause is at least in part not genetic.
Journal ArticleDOI
Is schizophrenia a neurodevelopmental disorder
Robin M. Murray,Shôn Lewis +1 more
TL;DR: Much research implicates the left rather than the right cerebral hemisphere in schizophrenia, and there is evidence that schizophrenics are more likely to be left handed than controls, and the normal development of lateralised cerebral dominance can be disrupted by premature birth with a resultant increase in left handedness.