Journal ArticleDOI
Child developmental risk-factors for adult schizophrenia in the british 1946 birth cohort
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TLDR
Differences between children destined to develop schizophrenia as adults and the general population were found across a range of developmental domains, and the origins of schizophrenia may be found in early life.About:
This article is published in The Lancet.The article was published on 1994-11-19. It has received 1326 citations till now. The article focuses on the topics: Cohort study & Odds ratio.read more
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Book ChapterDOI
Epidemiology of Prodrome in Familial Schizophrenia
R.K.R. Salokangas,Markus Heinimaa,Tuula Ilonen,T. Suomela,Jyrki Korkeila,M. Plathin,Terja Ristkari,Jukka Huttunen,Jarmo Hietala,Erkka Syvälahti,Tom McGlashan +10 more
TL;DR: The issues are addressed in the DEEP project, which is an epidemiological and follow-up study of prodromal symptomatology in high risk groups (first-degree relatives of schizophrenic patients, clinical populations), comprising clinical, neuropsychological, neurophysiological and neuroimaging data.
Journal ArticleDOI
Sex-specific effects of polygenic risk for schizophrenia on lifespan cognitive functioning in healthy individuals.
Elise Koch,Lars Nyberg,Anders Lundquist,Sara Pudas,Rolf Adolfsson,Karolina Kauppi,Karolina Kauppi +6 more
TL;DR: In this paper, the effect of a polygenic risk score (PRS) for schizophrenia on childhood, midlife, and late-life cognitive function in healthy individuals is modified by sex, and if PRS is linked to accelerated cognitive decline.
Journal ArticleDOI
Cortical cellular diversity and development in schizophrenia.
TL;DR: A survey of human brain cellular composition and development, levels of genomic regulation that determine cellular identity and developmental trajectories, and what is known about how genomic regulation is dysregulated in specific cell types in schizophrenia are provided.
Journal ArticleDOI
Precursors of cognitive impairments in psychotic disorders: a population-based study.
Mario Müller,Stefan Vetter,Mark Weiser,Franz Frey,Vladeta Ajdacic-Gross,Rolf-Dieter Stieglitz,Wulf Rössler,Wulf Rössler +7 more
TL;DR: The results confirm the importance of low IQ as characteristic of psychoses and show that premorbid intellectual deficits are common in people who go on to develop psychosis, and neurodegenerative disease processes may also precipitate further declines in fluid cognitive functions.
Journal ArticleDOI
Self-report of family functioning and risk for psychotic disorders in male adolescents with behavioural disturbances.
Mark Weiser,Mark Weiser,Avi Reichenberg,Nomi Werbeloff,Efrat Kravitz,Demian Halperin,G. Lubin,M Shmushkevitch,Rinat Yoffe,Jean Addington,Michael H. Davidson,Michael H. Davidson +11 more
TL;DR: This study aims to examine family functioning prior to the onset of psychosis, indicating that a poor family environment might affect vulnerability for the later manifestation of psychotic illness.
References
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Journal ArticleDOI
Implications of normal brain development for the pathogenesis of schizophrenia
TL;DR: The findings suggest that nonspecific histopathology exists in the limbic system, diencephalon, and prefrontal cortex, that the pathology occurs early in development, and that the causative process is inactive long before the diagnosis is made.
Book
The strategy of preventive medicine
TL;DR: This chapter discusses the relation of risk to exposure, prevention for individuals and the 'high-risk' strategy, and the population strategy of prevention.
Journal ArticleDOI
Adult Schizophrenia Following Prenatal Exposure to an Influenza Epidemic
TL;DR: It is suggested that it is less the type than the timing of the disturbance during fetal neural development that is critical in determining risk for schizophrenia.
Journal ArticleDOI
Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia.
Richard L. Suddath,George W. Christison,E. Fuller Torrey,Manuel F. Casanova,Daniel R. Weinberger +4 more
TL;DR: In this article, the authors found that subtle abnormalities of cerebral anatomy (namely, small anterior hippocampi and enlarged lateral and third ventricles) are consistent neuropathologic features of schizophrenia and that their cause is at least in part not genetic.
Journal ArticleDOI
Is schizophrenia a neurodevelopmental disorder
Robin M. Murray,Shôn Lewis +1 more
TL;DR: Much research implicates the left rather than the right cerebral hemisphere in schizophrenia, and there is evidence that schizophrenics are more likely to be left handed than controls, and the normal development of lateralised cerebral dominance can be disrupted by premature birth with a resultant increase in left handedness.