Journal ArticleDOI
Child developmental risk-factors for adult schizophrenia in the british 1946 birth cohort
TLDR
Differences between children destined to develop schizophrenia as adults and the general population were found across a range of developmental domains, and the origins of schizophrenia may be found in early life.About:
This article is published in The Lancet.The article was published on 1994-11-19. It has received 1326 citations till now. The article focuses on the topics: Cohort study & Odds ratio.read more
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Book ChapterDOI
An Attachment Perspective on Schizophrenia: The Role of Disorganized Attachment, Dissociation and Mentalization
Giovanni Liotti,Andrew Gumley +1 more
TL;DR: Dozier et al. as discussed by the authors found that attachment security is compromised in individuals diagnosed with schizophrenia, and no developmental pathway unique to schizophrenia has been found to lead from the low levels of parental care and high levels of parent overprotection.
Journal ArticleDOI
Prenatal nutrition, epigenetics and schizophrenia risk: can we test causal effects?
James B. Kirkbride,James B. Kirkbride,Ezra Susser,Marija Kundakovic,Jacob K. Kresovich,George Davey Smith,Caroline L Relton +6 more
TL;DR: Evidence that prenatal nutrition is linked to epigenetic outcomes in offspring and schizophrenia in offspring, and that schizophrenia is associated with epigenetic changes is considered, and one-carbon metabolism is focused upon as a mediator of the pathway between perturbed prenatal nutrition and the subsequent risk of schizophrenia.
Journal ArticleDOI
The association between early autistic traits and psychotic experiences in adolescence
TL;DR: Children whose mothers had concerns about autistic traits in early life, in particular with regard to speech development or 'rituals'/'habits', were more likely to develop psychotic experiences in early adolescence.
Journal ArticleDOI
Suicidal attempts and increased right amygdala volume in schizophrenia.
Ilaria Spoletini,Fabrizio Piras,Sabrina Fagioli,Ivo Alex Rubino,Giovanni Martinotti,Alberto Siracusano,Carlo Caltagirone,Gianfranco Spalletta +7 more
TL;DR: The findings suggest that right amygdala hypertrophy may be a risk factor for suicide attempts in patients with schizophrenia and this could be relevant for suicide prevention.
Journal ArticleDOI
Early Developmental Disturbances of Cortical Inhibitory Neurons: Contribution to Cognitive Deficits in Schizophrenia
David W. Volk,David A. Lewis +1 more
TL;DR: This review article proposes a strategy to investigate how alterations in the expression of developmental regulators of subpopulations of cortical GABA neurons may contribute to the pathogenesis of cortical inhibitory neuron dysfunction and consequently cognitive impairments in schizophrenia.
References
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Journal ArticleDOI
Implications of normal brain development for the pathogenesis of schizophrenia
TL;DR: The findings suggest that nonspecific histopathology exists in the limbic system, diencephalon, and prefrontal cortex, that the pathology occurs early in development, and that the causative process is inactive long before the diagnosis is made.
Book
The strategy of preventive medicine
TL;DR: This chapter discusses the relation of risk to exposure, prevention for individuals and the 'high-risk' strategy, and the population strategy of prevention.
Journal ArticleDOI
Adult Schizophrenia Following Prenatal Exposure to an Influenza Epidemic
TL;DR: It is suggested that it is less the type than the timing of the disturbance during fetal neural development that is critical in determining risk for schizophrenia.
Journal ArticleDOI
Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia.
Richard L. Suddath,George W. Christison,E. Fuller Torrey,Manuel F. Casanova,Daniel R. Weinberger +4 more
TL;DR: In this article, the authors found that subtle abnormalities of cerebral anatomy (namely, small anterior hippocampi and enlarged lateral and third ventricles) are consistent neuropathologic features of schizophrenia and that their cause is at least in part not genetic.
Journal ArticleDOI
Is schizophrenia a neurodevelopmental disorder
Robin M. Murray,Shôn Lewis +1 more
TL;DR: Much research implicates the left rather than the right cerebral hemisphere in schizophrenia, and there is evidence that schizophrenics are more likely to be left handed than controls, and the normal development of lateralised cerebral dominance can be disrupted by premature birth with a resultant increase in left handedness.