Dose response of the 16p11.2 distal copy number variant on intracranial volume and basal ganglia
Ida E Sønderby,Omar Gustafsson,Nhat Trung Doan,Derrek P. Hibar,Derrek P. Hibar,Sandra Martin-Brevet,Abdel Abdellaoui,David Ames,Katrin Amunts,Michael Andersson,Nicola J. Armstrong,Manon Bernard,Nicholas B. Blackburn,John Blangero,Dorret I. Boomsma,Janita Bralten,Hans-Richard Brattbak,Hans-Richard Brattbak,Henry Brodaty,Rachel M. Brouwer,Robin Bülow,Vince D. Calhoun,Svenja Caspers,Gianpiero L. Cavalleri,Chi-Hua Chen,Sven Cichon,Sven Cichon,Simone Ciufolini,Aiden Corvin,Benedicto Crespo-Facorro,Joanne E. Curran,Anders M. Dale,Shareefa Dalvie,Paola Dazzan,Paola Dazzan,Eco J. C. de Geus,Eco J. C. de Geus,Greig I. de Zubicaray,Sonja M C de Zwarte,Norman Delanty,Norman Delanty,Anouk den Braber,Anouk den Braber,Sylvane Desrivières,Gary Donohoe,Gary Donohoe,Bogdan Draganski,Bogdan Draganski,Stefan Ehrlich,Stefan Ehrlich,Thomas Espeseth,Thomas Espeseth,Simon E. Fisher,Simon E. Fisher,Barbara Franke,Vincent Frouin,Masaki Fukunaga,Thomas Gareau,David C. Glahn,David C. Glahn,Hans J. Grabe,Nynke A. Groenewold,Jan Haavik,Asta Håberg,Ryota Hashimoto,Jayne Y. Hehir-Kwa,Andreas Heinz,Manon H.J. Hillegers,Manon H.J. Hillegers,Per Hoffmann,Per Hoffmann,Per Hoffmann,Laurena Holleran,Jouke-Jan Hottenga,Hilleke E Hulshoff,Masashi Ikeda,Neda Jahanshad,Terry L. Jernigan,Christiane Jockwitz,Stefan Johansson,Stefan Johansson,Gudrun A. Jonsdottir,Erik G. Jönsson,Erik G. Jönsson,René S. Kahn,Tobias Kaufmann,Sinead Kelly,Masataka Kikuchi,Emma Knowles,Knut K. Kolskår,Knut K. Kolskår,John B.J. Kwok,Stephanie Le Hellard,Stephanie Le Hellard,Costin Leu,Costin Leu,Jingyu Liu,Jingyu Liu,Astri J. Lundervold,Arvid Lundervold,Nicholas G. Martin,Karen A. Mather,Samuel R. Mathias,Mark McCormack,Mark McCormack,Katie L. McMahon,Allan F. McRae,Yuri Milaneschi,Clara Moreau,Derek W. Morris,Derek W. Morris,David Mothersill,Thomas W. Mühleisen,Robin M. Murray,Jan Egil Nordvik,Lars Nyberg,Loes M. Olde Loohuis,Roel A. Ophoff,Roel A. Ophoff,Tomáš Paus,Zdenka Pausova,Brenda W.J.H. Penninx,Juan M. Peralta,Bruce Pike,Carlos Prieto,Sara Pudas,Erin Burke Quinlan,Daniel Quintana,Daniel Quintana,Céline S. Reinbold,Céline S. Reinbold,Tiago Reis Marques,Tiago Reis Marques,Alexandre Reymond,Geneviève Richard,Geneviève Richard,Borja Rodriguez-Herreros,Borja Rodriguez-Herreros,Roberto Roiz-Santiañez,Jarek Rokicki,James Rucker,James Rucker,Perminder S. Sachdev,Anne-Marthe Sanders,Anne-Marthe Sanders,Anne-Marthe Sanders,Sigrid Botne Sando,Lianne Schmaal,Lianne Schmaal,Peter R. Schofield,Peter R. Schofield,Andrew J. Schork,Gunter Schumann,Jean Shin,Jean Shin,Elena Shumskaya,Sanjay M. Sisodiya,Vidar M. Steen,Vidar M. Steen,Dan J. Stein,Dan J. Stein,Stacy Steinberg,Lachlan T. Strike,Alexander Teumer,Anbu Thalamuthu,Diana Tordesillas-Gutiérrez,Jessica A. Turner,Torill Ueland,Anne Uhlmann,Magnus O. Ulfarsson,Magnus O. Ulfarsson,Dennis van 't Ent,Dennis van der Meer,Neeltje E.M. van Haren,Anja Vaskinn,Evangelos Vassos,G. Bragi Walters,G. Bragi Walters,Yunpeng Wang,Wei Wen,Christopher D. Whelan,Katharina Wittfeld,Margie Wright,Margie Wright,Hidenaga Yamamori,Tetyana Zayats,Ingrid Agartz,Lars T. Westlye,Lars T. Westlye,Sébastien Jacquemont,Srdjan Djurovic,Srdjan Djurovic,Hreinn Stefansson,Kari Stefansson,Kari Stefansson,Paul M. Thompson,Ole A. Andreassen +196 more
TLDR
This is the first brain MRI study of the impact of the 16p11.2 distal CNV, and it is demonstrated a specific effect on subcortical brain structures, suggesting a neuropathological pattern underlying the neurodevelopmental syndromes.Abstract:
Carriers of large recurrent copy number variants (CNVs) have a higher risk of developing neurodevelopmental disorders. The 16p11.2 distal CNV predisposes carriers to e.g., autism spectrum disorder and schizophrenia. We compared subcortical brain volumes of 12 16p11.2 distal deletion and 12 duplication carriers to 6882 non-carriers from the large-scale brain Magnetic Resonance Imaging collaboration, ENIGMA-CNV. After stringent CNV calling procedures, and standardized FreeSurfer image analysis, we found negative dose-response associations with copy number on intracranial volume and on regional caudate, pallidum and putamen volumes (β = -0.71 to -1.37; P < 0.0005). In an independent sample, consistent results were obtained, with significant effects in the pallidum (β = -0.95, P = 0.0042). The two data sets combined showed significant negative dose-response for the accumbens, caudate, pallidum, putamen and ICV (P = 0.0032, 8.9 × 10-6, 1.7 × 10-9, 3.5 × 10-12 and 1.0 × 10-4, respectively). Full scale IQ was lower in both deletion and duplication carriers compared to non-carriers. This is the first brain MRI study of the impact of the 16p11.2 distal CNV, and we demonstrate a specific effect on subcortical brain structures, suggesting a neuropathological pattern underlying the neurodevelopmental syndromes.read more
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ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries
Paul M. Thompson,Neda Jahanshad,Christopher R.K. Ching,Lauren E. Salminen,Sophia I. Thomopoulos,Joanna Bright,Bernhard T. Baune,Bernhard T. Baune,Bernhard T. Baune,Sara Bertolín,Janita Bralten,Willem B Bruin,Robin Bülow,Jian Chen,Yann Chye,Udo Dannlowski,Carolien G.F. de Kovel,Carolien G.F. de Kovel,Gary Donohoe,Lisa T. Eyler,Lisa T. Eyler,Stephen V. Faraone,Pauline Favre,Courtney A. Filippi,Thomas Frodl,Thomas Frodl,Thomas Frodl,Daniel Garijo,Yolanda Gil,Hans J. Grabe,Hans J. Grabe,Katrina L. Grasby,Tomas Hajek,Tomas Hajek,Laura K.M. Han,Sean N. Hatton,Sean N. Hatton,Kevin Hilbert,Tiffany C. Ho,Tiffany C. Ho,Laurena Holleran,Georg Homuth,Norbert Hosten,Josselin Houenou,Iliyan Ivanov,Tianye Jia,Tianye Jia,Sinead Kelly,Sinead Kelly,Marieke Klein,Marieke Klein,Jun Soo Kwon,Jun Soo Kwon,Max A. Laansma,Jeanne Leerssen,Ulrike Lueken,Abraham Nunes,Joseph O' Neill,Nils Opel,Fabrizio Piras,Federica Piras,Merel Postema,Elena Pozzi,Natalia Shatokhina,Carles Soriano-Mas,Carles Soriano-Mas,Gianfranco Spalletta,Daqiang Sun,Daqiang Sun,Alexander Teumer,Amanda K. Tilot,Leonardo Tozzi,Celia van der Merwe,Celia van der Merwe,Eus J.W. Van Someren,Eus J.W. Van Someren,Guido van Wingen,Henry Völzke,Esther Walton,Lei Wang,Anderson M. Winkler,Katharina Wittfeld,Katharina Wittfeld,Margaret J. Wright,Je-Yeon Yun,Je-Yeon Yun,Guohao Zhang,Yanli Zhang-James,Bhim M. Adhikari,Ingrid Agartz,Ingrid Agartz,Moji Aghajani,André Aleman,Robert R. Althoff,Andre Altmann,Ole A. Andreassen,Ole A. Andreassen,David Baron,Brenda Bartnik-Olson,Janna Marie Bas-Hoogendam,Janna Marie Bas-Hoogendam,Arielle R. Baskin-Sommers,Carrie E. Bearden,Carrie E. Bearden,Laura A. Berner,Premika S.W. Boedhoe,Rachel M. Brouwer,Jan K. Buitelaar,Karen Caeyenberghs,Charlotte A.M. Cecil,Ronald A. Cohen,James H. Cole,Patricia J. Conrod,Stephane A. De Brito,Sonja M C de Zwarte,Emily L. Dennis,Emily L. Dennis,Emily L. Dennis,Sylvane Desrivières,Danai Dima,Danai Dima,Stefan Ehrlich,Carrie Esopenko,Graeme Fairchild,Simon E. Fisher,Simon E. Fisher,Jean-Paul Fouche,Jean-Paul Fouche,Clyde Francks,Clyde Francks,Sophia Frangou,Sophia Frangou,Barbara Franke,Hugh Garavan,David C. Glahn,Nynke A. Groenewold,Tiril P. Gurholt,Tiril P. Gurholt,Boris A. Gutman,Tim Hahn,Ian H. Harding,Dennis Hernaus,Derrek P. Hibar,Frank G. Hillary,Martine Hoogman,Hilleke E. Hulshoff Pol,Maria Jalbrzikowski,George A Karkashadze,Eduard T. Klapwijk,Rebecca C. Knickmeyer,Rebecca C. Knickmeyer,Peter Kochunov,Inga K. Koerte,Inga K. Koerte,Xiangzhen Kong,Sook-Lei Liew,Alexander P. Lin,Alexander P. Lin,Mark W. Logue,Eileen Luders,Eileen Luders,Fabio Macciardi,Scott Mackey,Andrew R. Mayer,Carrie R. McDonald,Agnes B. McMahon,Sarah E. Medland,Gemma Modinos,Rajendra A. Morey,Rajendra A. Morey,Sven C. Mueller,Sven C. Mueller,Pratik Mukherjee,Leyla Namazova-Baranova,Talia M. Nir,Alexander Olsen,Peristera Paschou,Daniel S. Pine,Fabrizio Pizzagalli,Miguel E. Rentería,Jonathan D. Rohrer,Philipp G. Sämann,Lianne Schmaal,Gunter Schumann,Gunter Schumann,Mark S. Shiroishi,Sanjay M. Sisodiya,Dirk J.A. Smit,Ida E Sønderby,Ida E Sønderby,Dan J. Stein,Jason L. Stein,Masoud Tahmasian,David F. Tate,Jessica A. Turner,Odile A. van den Heuvel,Nic J.A. van der Wee,Ysbrand D. van der Werf,Theo G.M. van Erp,Neeltje E.M. van Haren,Neeltje E.M. van Haren,Daan van Rooij,Laura S van Velzen,Ilya M. Veer,Dick J. Veltman,Julio E. Villalon-Reina,Henrik Walter,Christopher D. Whelan,Christopher D. Whelan,Elisabeth A. Wilde,Elisabeth A. Wilde,Mojtaba Zarei,Vladimir Zelman,Vladimir Zelman +213 more
TL;DR: This review summarizes the last decade of work by the ENIGMA Consortium, a global alliance of over 1400 scientists across 43 countries, studying the human brain in health and disease, and highlights the advantages of collaborative large-scale coordinated data analyses for testing reproducibility and robustness of findings.
Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects
Christian R. Marshall,Daniel P. Howrigan,Daniele Merico,Bhooma Thiruvahindrapuram,Wenting Wu,Douglas S. Greer,Danny Antaki,Aniket Shetty,Peter Holmans,Dalila Pinto,Madhusudan Gujral,William M. Brandler,Dheeraj Malhotra,Zhouzhi Wang,Karin V. Fuentes Fajarado,Michelle S. Maile,Stephan Ripke,Ingrid Agartz,Margot Albus,Madeline Alexander,Farooq Amin,Joshua R. Atkins,Silviu Alin Bacanu,Richard A. Belliveau,Sarah E. Bergen,Marcelo Ertalan,Elizabeth Bevilacqua,Tim B. Bigdeli,Donald W. Black,Richard Bruggeman,Nancy G. Buccola,Randy L. Buckner,Brendan Bulik-Sullivan,William Byerley,Wiepke Cahn,Guiqing Cai,Murray J. Cairns,Dominique Campion,Rita M. Cantor,Vaughan J. Carr,Noa Carrera,Stanley V. Catts,Kimberley D. Chambert,Wei Cheng,C. Robert Cloninger,David Cohen,Paul Cormican,Nicholas John Craddock,Benedicto Crespo-Facorro,James J. Crowley,David Curtis,Michael Davidson,Kenneth L. Davis,Franziska Degenhardt,Jurgen Del Favero,Lynn E. DeLisi,Dimitris Dikeos,Timothy G. Dinan,Srdjan Djurovic,Gary Donohoe,Elodie Drapeau,Jubao Duan,Frank Dudbridge,Peter Eichhammer,Johan G. Eriksson,Valentina Escott-Price,Laurent Essioux,Ayman H. Fanous,Kai-How Farh,Martilias S. Farrell,Josef Frank,Lude Franke,Robert B. Freedman,Nelson B. Freimer,Joseph I. Friedman,Andreas J. Forstner,Menachem Fromer,Giulio Genovese,Lyudmila Georgieva,Elliot S. Gershon,Ina Giegling,Paola Giusti-Rodríguez,Stephanie Godard,Jacqueline I. Goldstein,Jacob Gratten,Lieuwe de Haan,Marian L. Hamshere,Mark Hansen,Thomas Hansen,Vahram Haroutunian,Annette M. Hartmann,Frans Henskens,Stefan Herms,Joel N. Hirschhorn,Per Hoffinann,A. Hofman,Hailiang Huang,Masashi Ikeda,Inge Joa,Anna K. Kähler,René S. Kahn,Luba Kalaydjieva,Juha Karjalainen,David J. Kavanagh,Matthew C. Keller,Brian Kelly,James L. Kennedy,Yunjung Kim,James A. Knowles,Bettina Konte,Claudine Laurent,Phil Lee,S. Hong Lee,Sophie E. Legge,Bernard Lerer,Deborah L. Levy,Kung-Yee Liang,Jeffrey A. Lieberman,Jouko Lönnqvist,Carmel M. Loughland,Patrik K. E. Magnusson,Brion S. Maher,Wolfgang Maier,Jacques Mallet,Manuel Mattheisen,Morten Mattingsdal,Robert W. McCarley,Colm McDonald,Andrew M. McIntosh,Sandra Meier,Carin J. Meijer,Ingrid Melle,Raquelle I. Mesholam-Gately,Andres Metspalu,Patricia T. Michie,Lili Milani,Vihra Milanova,Younes Mokrab,Derek W. Morris,Bertram Müller-Myhsok,Kieran C. Murphy,Robin M. Murray,Inez Myin-Germeys,Igor Nenadic,Deborah A. Nertney,Gerald Nestadt,Kristin K. Nicodemus,Laura Nisenbaum,Annelie Nordin,Eadbhard O'Callaghan,Colm O'Dushlaine,Sang-Yun Oh,Ann Olincy,Line Olsen,F. Anthony O'Neill,Jim van Os,Christos Pantelis,George N. Papadimitriou,Elena Parkhomenko,Michele T. Pato,Tiina Paunio,Diana O. Perkins,Tune H. Pers,Olli Pietiläinen,Jonathan Pimm,Andrew Pocklington,John Powell,Alkes L. Price,Ann E. Pulver,Shaun Purcell,Digby Quested,Henrik B. Rasmussen,Abraham Reichenberg,Mark Reimers,Alexander Richards,Joshua L. Roffman,Panos Roussos,Douglas M. Ruderfer,Veikko Salomaa,Alan R. Sanders,Adam Savitz,Ulrich Schall,Thomas G. Schulze,Sibylle G. Schwab,Edward M. Scolnick,Rodney J. Scott,Larry J. Seidman,Jianxin Shi,Jeremy M. Silverman,Jordan W. Smoller,Erik Söderman,Chris C. A. Spencer,Eli A. Stahl,Eric Strengman,Jana Strohmaier,T. Scott Stroup,Jaana Suvisaari,Dragan M. Svrakic,Jin P. Szatkiewicz,Srinivas Thirumalai,Paul A. Tooney,Juha Veijola,Peter M. Visscher,John L. Waddington,Dermot Walsh,Bradley T. Webb,Mark Weiser,Dieter B. Wildenauer,Nigel Williams,Stephanie Williams,Stephanie H. Witt,Aaron R. Wolen,Brandon Wormley,Naomi R. Wray,Jing Qin Wu,Clement C. Zai,Rolf Adolfsson,Ole A. Andreassen,Douglas Blackwood,Elvira Bramon,Joseph D. Buxbaum,Sven Cichon,David A. Collier,Aiden Corvin,Mark J. Daly,Ariel Darvasi,Enrico Domenici,Tõnu Esko,Pablo V. Gejman,Michael Gill,Hugh Gurling,Christina M. Hultman,Nakao Iwata,Assen Jablensky,Erik G. Jönsson,Kenneth S. Kendler,George Kirov,Jo Knight,Douglas F. Levinson,Qingqin S. Li,Steven A. McCarroll,Andrew McQuillin,Jennifer L. Moran,Bryan J. Mowry,Markus M. Nöthen,Roel A. Ophoff,Michael John Owen,Aarno Palotie,Carlos N. Pato,Tracey L. Petryshen,Danielle Posthuma,Marcella Rietschel,Brien P. Riley,Dan Rujescu,Pamela Sklar,David St Clair,James T.R. Walters,Thomas Werge,Patrick F. Siillivan,Michael Conlon O'Donovan,Stephen W. Scherer,Benjamin M. Neale,Jonathan Sebat +262 more
TL;DR: A centralized analysis pipeline was applied to a SCZ cohort of 21,094 cases and 20,227 controls and Suggestive support was found for eight additional candidate susceptibility and protective loci, which consisted predominantly of CNVs mediated by nonallelic homologous recombination.
Journal ArticleDOI
Brain Imaging Genomics: Integrated Analysis and Machine Learning
Li Shen,Paul M. Thompson +1 more
TL;DR: This work provides an up-to-date and comprehensive review of statistical and machine learning methods for brain imaging genomics, as well as a practical discussion on method selection for various biomedical applications.
Journal ArticleDOI
Association of Copy Number Variation of the 15q11.2 BP1-BP2 Region With Cortical and Subcortical Morphology and Cognition
Dennis van der Meer,Dennis van der Meer,Ida E Sønderby,Tobias Kaufmann,G. Bragi Walters,G. Bragi Walters,Abdel Abdellaoui,Abdel Abdellaoui,David Ames,Katrin Amunts,Micael Andersson,Nicola J. Armstrong,Manon Bernard,Nicholas B. Blackburn,John Blangero,Dorret I. Boomsma,Dorret I. Boomsma,Henry Brodaty,Rachel M. Brouwer,Robin Bülow,Wiepke Cahn,Vince D. Calhoun,Vince D. Calhoun,Svenja Caspers,Gianpiero L. Cavalleri,Christopher R.K. Ching,Christopher R.K. Ching,Sven Cichon,Simone Ciufolini,Aiden Corvin,Benedicto Crespo-Facorro,Joanne E. Curran,Shareefa Dalvie,Paola Dazzan,Eco J. C. de Geus,Eco J. C. de Geus,Greig I. de Zubicaray,Sonja M C de Zwarte,Norman Delanty,Anouk den Braber,Sylvane Desrivières,Marta Di Forti,Joanne L. Doherty,Gary Donohoe,Stefan Ehrlich,Else Eising,Thomas Espeseth,Simon E. Fisher,Simon E. Fisher,Tormod Fladby,Oleksandr Frei,Vincent Frouin,Masaki Fukunaga,Masaki Fukunaga,Thomas Gareau,David C. Glahn,Hans J. Grabe,Nynke A. Groenewold,Omar Gustafsson,Jan Haavik,Asta Håberg,Ryota Hashimoto,Jayne Y. Hehir-Kwa,Derrek P. Hibar,Manon H.J. Hillegers,Per Hoffmann,Per Hoffmann,Laurena Holleran,Jouke-Jan Hottenga,Jouke-Jan Hottenga,Hilleke E. Hulshoff Pol,Masashi Ikeda,Sébastien Jacquemont,Neda Jahanshad,Christiane Jockwitz,Stefan Johansson,Erik G. Jönsson,Erik G. Jönsson,Masataka Kikuchi,Emma Knowles,John B.J. Kwok,John B.J. Kwok,Stephanie Le Hellard,David Edmund Johannes Linden,David Edmund Johannes Linden,Jingyu Liu,Arvid Lundervold,Astri J. Lundervold,Nicholas G. Martin,Karen A. Mather,Karen A. Mather,Samuel R. Mathias,Katie L. McMahon,Allan F. McRae,Sarah E. Medland,Torgeir Moberget,Clara Moreau,Derek W. Morris,Thomas W. Mühleisen,Thomas W. Mühleisen,Robin M. Murray,Jan Egil Nordvik,Lars Nyberg,Loes M. Olde Loohuis,Roel A. Ophoff,Michael John Owen,Tomáš Paus,Zdenka Pausova,Juan M. Peralta,Bruce Pike,Carlos Prieto,Erin Burke Quinlan,Céline S. Reinbold,Céline S. Reinbold,Tiago Reis Marques,Tiago Reis Marques,James Rucker,Perminder S. Sachdev,Sigrid Botne Sando,Peter R. Schofield,Peter R. Schofield,Andrew J. Schork,Gunter Schumann,Jean Shin,Elena Shumskaya,Ana I. Silva,Ana I. Silva,Sanjay M. Sisodiya,Vidar M. Steen,Dan J. Stein,Lachlan T. Strike,Christian K. Tamnes,Alexander Teumer,Anbupalam Thalamuthu,Diana Tordesillas-Gutiérrez,Anne Uhlmann,Magnus O. Ulfarsson,Magnus O. Ulfarsson,Dennis van 't Ent,Marianne Bernadette van den Bree,Evangelos Vassos,Wei Wen,Katharina Wittfeld,Margaret J. Wright,Tetyana Zayats,Tetyana Zayats,Tetyana Zayats,Anders M. Dale,Srdjan Djurovic,Srdjan Djurovic,Ingrid Agartz,Ingrid Agartz,Lars T. Westlye,Hreinn Stefansson,Kari Stefansson,Kari Stefansson,Paul M. Thompson,Ole A. Andreassen +157 more
TL;DR: Findings from the largest CNV neuroimaging study to date provide evidence that 15q11.2 BP1-BP2 structural variation is associated with brain morphology and cognition, with deletion carriers being particularly affected.
Journal ArticleDOI
16p11.2 Copy Number Variations and Neurodevelopmental Disorders.
Benjamin Rein,Zhen Yan +1 more
TL;DR: Mice with 16p11.2 deletions or duplications recapitulate many core behavioral phenotypes, including social and cognitive deficits, and exhibit altered synaptic function across various brain areas, which is associated with a range of neurodevelopmental disorders.
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Biological insights from 108 schizophrenia-associated genetic loci
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Davis,Franziska Degenhardt,Jurgen Del Favero,Ditte Demontis,Ditte Demontis,Dimitris Dikeos,Timothy G. Dinan,Srdjan Djurovic,Gary Donohoe,Gary Donohoe,Elodie Drapeau,Jubao Duan,Frank Dudbridge,Naser Durmishi,Peter Eichhammer,Johan G. Eriksson,Johan G. Eriksson,Valentina Escott-Price,Laurent Essioux,Ayman H. Fanous,Martilias S. Farrell,Josef Frank,Lude Franke,Robert Freedman,Nelson B. Freimer,Marion Friedl,Joseph I. Friedman,Menachem Fromer,Menachem Fromer,Menachem Fromer,Giulio Genovese,Lyudmila Georgieva,Ina Giegling,Ina Giegling,Paola Giusti-Rodríguez,Stephanie Godard,Jacqueline I. Goldstein,Jacqueline I. Goldstein,Vera Golimbet,Srihari Gopal,Jacob Gratten,Lieuwe de Haan,Christian Hammer,Marian L. Hamshere,Mark Hansen,Thomas Hansen,Vahram Haroutunian,Vahram Haroutunian,Annette M. Hartmann,Frans Henskens,Stefan Herms,Stefan Herms,Joel N. Hirschhorn,Joel N. Hirschhorn,Per Hoffmann,Per Hoffmann,A. Hofman,Mads V. Hollegaard,David M. Hougaard,Masashi Ikeda,Inge Joa,Antonio Julià,René S. Kahn,Luba Kalaydjieva,Sena Karachanak-Yankova,Juha Karjalainen,David J. Kavanagh,Matthew C. Keller,James L. Kennedy,Andrey Khrunin,Yunjung Kim,Janis Klovins,James A. Knowles,Bettina Konte,Vaidutis Kučinskas,Zita Ausrele Kucinskiene,Hana Kuzelova-Ptackova,Anna K. Kähler,Claudine Laurent,Jimmy Lee Chee Keong,S. Hong Lee,Sophie E. Legge,Bernard Lerer,Miaoxin Li,Tao Li,Kung-Yee Liang,Jeffrey A. Lieberman,Svetlana A. Limborska,Carmel M. Loughland,Jan Lubinski,Jouko Lönnqvist,Milan Macek,Patrik K. E. Magnusson,Brion S. Maher,Wolfgang Maier,J. Mallet,Sara Marsal,Manuel Mattheisen,Manuel Mattheisen,Manuel Mattheisen,Morten Mattingsdal,Robert W. McCarley,Colm McDonald,Andrew M. McIntosh,Sandra Meier,Carin J. Meijer,Béla Melegh,Ingrid Melle,Raquelle I. Mesholam-Gately,Andres Metspalu,Patricia T. Michie,Lili Milani,Vihra Milanova,Younes Mokrab,Derek W. Morris,Derek W. Morris,Ole Mors,Ole Mors,Kieran C. Murphy,Robin M. Murray,Inez Myin-Germeys,Bertram Mueller-Myhsok,Mari Nelis,Igor Nenadic,Deborah A. Nertney,Gerald Nestadt,Kristin K. Nicodemus,Liene Nikitina-Zake,Laura Nisenbaum,Annelie Nordin,Eadbhard O'Callaghan,Colm O'Dushlaine,F. Anthony O'Neill,Sang-Yun Oh,Ann Olincy,Line Olsen,Jim van Os,Jim van Os,Christos Pantelis,George N. Papadimitriou,Sergi Papiol,Elena Parkhomenko,Michele T. Pato,Tiina Paunio,Tiina Paunio,Milica Pejovic-Milovancevic,Diana O. Perkins,Olli Pietiläinen,Olli Pietiläinen,Jonathan Pimm,Andrew Pocklington,John Powell,Alkes L. Price,Alkes L. Price,Ann E. Pulver,Shaun Purcell,Digby Quested,Henrik B. Rasmussen,Abraham Reichenberg,Mark Reimers,Alexander Richards,Joshua L. Roffman,Panos Roussos,Douglas M. Ruderfer,Douglas M. Ruderfer,Veikko Salomaa,Alan R. Sanders,Ulrich Schall,Christian R. Schubert,Thomas G. Schulze,Thomas G. Schulze,Sibylle G. Schwab,Edward M. Scolnick,Rodney J. Scott,Larry J. Seidman,Jianxin Shi,Engilbert Sigurdsson,Teimuraz Silagadze,Jeremy M. Silverman,Jeremy M. Silverman,Kang Sim,Petr Slominsky,Jordan W. Smoller,Jordan W. Smoller,Hon-Cheong So,Chris C. A. Spencer,Eli A. Stahl,Eli A. Stahl,Hreinn Stefansson,Stacy Steinberg,Elisabeth Stögmann,Richard E. Straub,Eric Strengman,Jana Strohmaier,T. Scott Stroup,Mythily Subramaniam,Jaana Suvisaari,Dragan M. Svrakic,Jin P. Szatkiewicz,Erik Söderman,Srinivas Thirumalai,Draga Toncheva,Sarah Tosato,Juha Veijola,John L. Waddington,Dermot Walsh,Dai Wang,Qiang Wang,Bradley T. Webb,Mark Weiser,Dieter B. Wildenauer,Nigel Williams,Stephanie Williams,Stephanie H. Witt,Aaron R. Wolen,Emily H. M. Wong,Brandon Wormley,Hualin Simon Xi,Clement C. Zai,Xuebin Zheng,Fritz Zimprich,Naomi R. Wray,Kari Stefansson,Peter M. Visscher,Rolf Adolfsson,Ole A. Andreassen,Douglas Blackwood,Elvira Bramon,Joseph D. Buxbaum,Anders D. Børglum,Anders D. Børglum,Sven Cichon,Sven Cichon,Ariel Darvasi,Enrico Domenici,Hannelore Ehrenreich,Tõnu Esko,Tõnu Esko,Tõnu Esko,Pablo V. Gejman,Michael Gill,Hugh Gurling,Christina M. Hultman,Nakao Iwata,Assen Jablensky,Erik G. Jönsson,Erik G. Jönsson,Kenneth S. Kendler,George Kirov,Jo Knight,Todd Lencz,Todd Lencz,Douglas F. Levinson,Qingqin S. Li,Jianjun Liu,Jianjun Liu,Anil K. Malhotra,Anil K. Malhotra,Steven A. McCarroll,Steven A. McCarroll,Andrew McQuillin,Jennifer L. Moran,Preben Bo Mortensen,Preben Bo Mortensen,Bryan J. Mowry,Markus M. Noethen,Roel A. Ophoff,Roel A. Ophoff,Michael John Owen,Aarno Palotie,Aarno Palotie,Aarno Palotie,Carlos N. Pato,Tracey L. Petryshen,Tracey L. Petryshen,Danielle Posthuma,Danielle Posthuma,Marcella Rietschel,Brien P. Riley,Dan Rujescu,Dan Rujescu,Pak C. Sham,Pamela Sklar,David St Clair,Daniel R. Weinberger,Jens R. Wendland,Thomas Werge,Thomas Werge,Mark J. Daly,Mark J. Daly,Patrick F. Sullivan,Patrick F. Sullivan,Michael Conlon O'Donovan +354 more
Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects
Christian R. Marshall,Daniel P. Howrigan,Daniel P. Howrigan,Daniele Merico,Bhooma Thiruvahindrapuram,Wenting Wu,Douglas S. Greer,Danny Antaki,Aniket Shetty,Peter Holmans,Peter Holmans,Dalila Pinto,Madhusudan Gujral,William M. Brandler,Dheeraj Malhotra,Dheeraj Malhotra,Zhouzhi Wang,Karin V Fuentes Fajarado,Michelle S. Maile,Stephan Ripke,Stephan Ripke,Ingrid Agartz,Ingrid Agartz,Margot Albus,Madeline Alexander,Farooq Amin,Farooq Amin,Joshua R. Atkins,Silviu Alin Bacanu,Rich Belliveau,Sarah E. Bergen,Sarah E. Bergen,Marcelo Bertalan,Marcelo Bertalan,Elizabeth Bevilacqua,Tim B. Bigdeli,Donald W. Black,Richard Bruggeman,Nancy G. Buccola,Randy L. Buckner,Brendan Bulik-Sullivan,Brendan Bulik-Sullivan,William Byerley,Wiepke Cahn,Guiqing Cai,Murray J. Cairns,Dominique Campion,Rita M. Cantor,Vaughan J. Carr,Noa Carrera,Stanley V. Catts,Kimberley D. Chambert,Wei Cheng,C. Robert Cloninger,David Cohen,Paul Cormican,Nicholas John Craddock,Nicholas John Craddock,Benedicto Crespo-Facorro,James J. Crowley,David Curtis,David Curtis,Michael Davidson,Kenneth L. Davis,Franziska Degenhardt,Jurgen Del Favero,Lynn E. DeLisi,Dimitris Dikeos,Timothy G. Dinan,Srdjan Djurovic,Srdjan Djurovic,Gary Donohoe,Gary Donohoe,Elodie Drapeau,Jubao Duan,Jubao Duan,Frank Dudbridge,Peter Eichhammer,Joel Eriksson,Joel Eriksson,Valentina Escott-Price,Laurent Essioux,Ayman H. Fanous,Kai How Farh,Martilias S. Farrell,Josef Frank,Lude Franke,Robert Freedman,Nelson B. Freimer,Joseph I. Friedman,Andreas J. Forstner,Menachem Fromer,Giulio Genovese,Lyudmila Georgieva,Elliot S. Gershon,Ina Giegling,Ina Giegling,Paola Giusti-Rodríguez,Stephanie Godard,Jackie Goldstein,Jackie Goldstein,Jacob Gratten,Lieuwe de Haan,Marian L. Hamshere,Mark Hansen,Thomas Hansen,Thomas Hansen,Vahram Haroutunian,Annette M. Hartmann,Frans Henskens,Stefan Herms,Stefan Herms,Joel N. Hirschhorn,Joel N. Hirschhorn,Joel N. Hirschhorn,Per Hoffmann,Per Hoffmann,A. Hofman,Hailiang Huang,Hailiang Huang,Masashi Ikeda,Inge Joa,Anna K. Kähler,René S. Kahn,Luba Kalaydjieva,Juha Karjalainen,David H. Kavanagh,Matthew C. Keller,Brian Kelly,James L. Kennedy,James L. Kennedy,Yunjung Kim,James A. Knowles,Bettina Konte,Claudine Laurent,Pui Y. Lee,Pui Y. Lee,Sang Hong Lee,Sophie E. Legge,Bernard Lerer,Deborah L. Levy,Deborah L. Levy,Kung Yee Liang,Jeffrey A. Lieberman,Jouko Lönnqvist,Carmel M. Loughland,Patrik K. E. Magnusson,Brady J. Maher,Wolfgang Maier,Jacques Mallet,Manuel Mattheisen,Morten Mattingsdal,Robert W. McCarley,Colm McDonald,Andrew M. McIntosh,Sandra Meier,Carin J. Meijer,Ingrid Melle,Ingrid Melle,Raquelle I. Mesholam-Gately,Raquelle I. Mesholam-Gately,Andres Metspalu,Patricia T. Michie,Lili Milani,Vihra Milanova,Younes Mokrab,Derek W. Morris,Derek W. Morris,Bertram Müller-Myhsok,Bertram Müller-Myhsok,Kieran C. Murphy,Robin M. Murray,Inez Myin-Germeys,Igor Nenadic,Deborah A. Nertney,Gerald Nestadt,Kristin K. Nicodemus,Laura Nisenbaum,Annelie Nordin,Eadbhard O'Callaghan,Colm O'Dushlaine,Sang-Yun Oh,Ann Olincy,Line Olsen,Line Olsen,Francis A. O'Neill,Jim van Os,Jim van Os,Christos Pantelis,George N. Papadimitriou,Elena Parkhomenko,Michele T. Pato,Tiina Paunio,Diana O. Perkins,Tune H. Pers,Tune H. Pers,Tune H. Pers,Olli Pietiläinen,Olli Pietiläinen,Jonathan Pimm,Andrew Pocklington,John Powell,Alkes L. Price,Alkes L. Price,Ann E. Pulver,Shaun M. Purcell,Digby Quested,Henrik B. Rasmussen,Henrik B. Rasmussen,Abraham Reichenberg,Mark Reimers,Alexander Richards,Alexander Richards,Joshua L. Roffman,Panos Roussos,Douglas M. Ruderfer,Douglas M. Ruderfer,Veikko Salomaa,Alan R. Sanders,Alan R. Sanders,Adam Savitz,Ulrich Schall,Thomas G. Schulze,Thomas G. Schulze,Sibylle G. Schwab,Edward M. Scolnick,Rodney J. Scott,Larry J. Seidman,Larry J. Seidman,Jianxin Shi,Jeremy M. Silverman,Jeremy M. Silverman,Jordan W. Smoller,Jordan W. Smoller,Erik Söderman,Chris C. A. Spencer,Eli A. Stahl,Eli A. Stahl,Eric Strengman,Eric Strengman,Jana Strohmaier,T. Scott Stroup,Jaana Suvisaari,Dragan M. Svrakic,Jin P. Szatkiewicz,Srinivas Thirumalai,Paul A. Tooney,Juha Veijola,Peter M. Visscher,John L. Waddington,Dermot Walsh,Bradley T. Webb,Mark Weiser,Dieter B. Wildenauer,Nigel Williams,Stephanie Williams,Stephanie H. Witt,Aaron R. Wolen,Brandon Wormley,Naomi R. Wray,Jing Qin Wu,Clement C. Zai,Clement C. Zai,Rolf Adolfsson,Ole A. Andreassen,Ole A. Andreassen,Douglas Blackwood,Elvira Bramon,Joseph D. Buxbaum,Sven Cichon,David A. Collier,David A. Collier,Aiden Corvin,Mark J. Daly,Mark J. Daly,Ariel Darvasi,Enrico Domenici,Enrico Domenici,Tõnu Esko,Pablo V. Gejman,Pablo V. Gejman,Michael Gill,Hugh Gurling,Christina M. Hultman,Nakao Iwata,Assen Jablensky,Erik G. Jönsson,Erik G. Jönsson,Kenneth S. Kendler,George Kirov,Jo Knight,Jo Knight,Douglas F. Levinson,Qingqin Li,Steven A. McCarroll,Steven A. McCarroll,Andrew McQuillin,Jennifer L. Moran,Bryan J. Mowry,Markus M. Nöthen,Roel A. Ophoff,Roel A. Ophoff,Roel A. Ophoff,Michael John Owen,Michael John Owen,Aarno Palotie,Aarno Palotie,Aarno Palotie,Carlos N. Pato,Tracey L. Petryshen,Danielle Posthuma,Danielle Posthuma,Danielle Posthuma,Marcella Rietschel,Brien P. Riley,Dan Rujescu,Dan Rujescu,Pamela Sklar,David St Clair,James T.R. Walters,Thomas Werge,Thomas Werge,Thomas Werge,Patrick F. Sullivan,Patrick F. Sullivan,Michael Conlon O'Donovan,Michael Conlon O'Donovan,Stephen W. Scherer,Benjamin M. Neale,Jonathan Sebat +329 more
Cortical Brain Abnormalities in 4474 Individuals With Schizophrenia and 5098 Control Subjects via the Enhancing Neuro Imaging Genetics Through Meta Analysis (ENIGMA) Consortium
CNVs conferring risk of autism or schizophrenia affect cognition in controls
Hreinn Stefansson,Andreas Meyer-Lindenberg,Stacy Steinberg,Brynja B. Magnusdottir,Katrin Morgen,Sunna Arnarsdottir,Gyda Bjornsdottir,G. Bragi Walters,Gudrun A. Jonsdottir,Orla Doyle,Heike Tost,Oliver Grimm,Solveig Kristjansdottir,Heimir Snorrason,Solveig Davidsdottir,Larus J. Gudmundsson,Gudbjorn F. Jonsson,Berglind Stefansdottir,Isafold Helgadottir,Magnús Haraldsson,Birna Jonsdottir,Johan H. Thygesen,Adam J. Schwarz,Michael Didriksen,Tine B. Stensbøl,Michael Brammer,Shitij Kapur,Jonas G. Halldorsson,Stefan Hreidarsson,Evald Saemundsen,Engilbert Sigurdsson,Kari Stefansson +31 more