Journal ArticleDOI
Extracellular vesicle-packaged HIF-1α-stabilizing lncRNA from tumour-associated macrophages regulates aerobic glycolysis of breast cancer cells.
Fei Chen,Jianing Chen,Linbin Yang,Jiang Liu,Xiaoqian Zhang,Yin Zhang,Qingqiang Tu,Dong Yin,De-Chen Lin,Ping-Pui Wong,Di Huang,Yue Xing,Jinghua Zhao,Mengfeng Li,Qiang Liu,Fengxi Su,Shicheng Su,Erwei Song,Erwei Song +18 more
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TLDR
It is demonstrated that tumour-associated macrophages enhance the aerobic glycolysis and apoptotic resistance of breast cancer cells via the extracellular vesicle transmission of a myeloid-specific lncRNA, HIF-1α-stabilizing long noncoding RNA (HISLA).Abstract:
Metabolic reprogramming is a hallmark of cancer. Here, we demonstrate that tumour-associated macrophages (TAMs) enhance the aerobic glycolysis and apoptotic resistance of breast cancer cells via the extracellular vesicle (EV) transmission of a myeloid-specific lncRNA, HIF-1α-stabilizing long noncoding RNA (HISLA). Mechanistically, HISLA blocks the interaction of PHD2 and HIF-1α to inhibit the hydroxylation and degradation of HIF-1α. Reciprocally, lactate released from glycolytic tumour cells upregulates HISLA in macrophages, constituting a feed-forward loop between TAMs and tumour cells. Blocking EV-transmitted HISLA inhibits the glycolysis and chemoresistance of breast cancer in vivo. Clinically, HISLA expression in TAMs is associated with glycolysis, poor chemotherapeutic response and shorter survival of patients with breast cancer. Our study highlights the potential of lncRNAs as signal transducers that are transmitted between immune and tumour cells via EVs to promote cancer aerobic glycolysis.read more
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RNA delivery by extracellular vesicles in mammalian cells and its applications.
Killian P. O’Brien,Koen Breyne,Stefano Ughetto,Stefano Ughetto,Louise C. Laurent,Xandra O. Breakefield +5 more
TL;DR: This Review focuses on the current state of knowledge pertaining to packaging, transport and function of RNAs in extracellular vesicles and outlines the progress made thus far towards their clinical applications.
Journal ArticleDOI
Macrophages and Metabolism in the Tumor Microenvironment
TL;DR: The metabolic circuitries whereby TAMs condition the TME to support tumor growth and how such pathways can be therapeutically targeted are discussed.
Journal ArticleDOI
Immune cells within the tumor microenvironment: Biological functions and roles in cancer immunotherapy.
TL;DR: The biological functions of immune cells within TME and their roles in cancer immunotherapy are reviewed, and the perspectives of the basic studies for improving the effectiveness of the clinical use are discussed.
Journal ArticleDOI
DNA of neutrophil extracellular traps promotes cancer metastasis via CCDC25
Linbin Yang,Qiang Liu,Xiaoqian Zhang,Xinwei Liu,Boxuan Zhou,Jianing Chen,Di Huang,Jiaqian Li,Heliang Li,Fei Chen,Jiang Liu,Yue Xing,Xueman Chen,Shicheng Su,Erwei Song +14 more
TL;DR: Overall, a transmembrane DNA receptor is described that mediates NET-dependent metastasis, and it is suggested that targeting CCDC25 could be an appealing therapeutic strategy for the prevention of cancer metastasis.
Journal ArticleDOI
Regulation of glycolysis by the hypoxia-inducible factor (HIF): implications for cellular physiology.
S. J. Kierans,Cormac T. Taylor +1 more
TL;DR: The role of HIF‐1α is highlighted in the regulation of hypoxic glycolysis and its implications for physiological processes such as angiogenesis and immune cell effector function.
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