Cancer-derived exosomes trigger endothelial to mesenchymal transition followed by the induction of cancer-associated fibroblasts

doi:10.1016/J.ACTBIO.2018.07.001

Journal ArticleDOI

Cancer-derived exosomes trigger endothelial to mesenchymal transition followed by the induction of cancer-associated fibroblasts

Ju Hun Yeon, +11 more

- 01 Aug 2018 -

Acta Biomaterialia

- Vol. 76, pp 146-153

TLDR

An in vitro 3D EndMT model is presented to understand the progress of the CAF generation by recapitulating the 3D tumor microenvironment in a microfluidic device and can serve as a powerful tool to validate exosomal components that could be further developed to anti-cancer drugs.

About:

This article is published in Acta Biomaterialia.The article was published on 2018-08-01. It has received 100 citations till now. The article focuses on the topics: Exosome & Tumor microenvironment.

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The role of collagen in cancer: from bench to bedside

Shuai-Shuai Xu, +8 more

- 14 Sep 2019 -

Journal of Translational Medicine

TL;DR: The emerging understanding of the structural properties and functions of collagen in cancer will guide the development of new strategies for anticancer therapy and provide promising therapeutic options that can be readily translated from bench to bedside.

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Journal ArticleDOI

Exosomes: The next generation of endogenous nanomaterials for advanced drug delivery and therapy.

Wen Liao, +6 more

- 01 Mar 2019 -

Acta Biomaterialia

TL;DR: A comprehensive understanding of the properties and applications of exosomes, including their biogenesis, biofunctions, isolation, purification, and drug loading, and typical examples in drug delivery and therapy are provided.

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Journal ArticleDOI

Cancer-associated fibroblasts: overview, progress, challenges, and directions.

Ping Qinrong, +8 more

- 12 Mar 2021 -

Cancer Gene Therapy

TL;DR: A review of cancer-associated fibroblasts (CAFs) and tumor diagnosis and treatment can be found in this paper, where the authors summarized the definition, origin, biomarkers, generation mechanism, functions, heterogeneity, plasticity, subpopulations, pre-metastasis niches (PMN), immune microenvironment, and targeted therapy of CAFs, and proposed possible future research directions based on existing reports.

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Journal ArticleDOI

Breast cancer-derived exosomes regulate cell invasion and metastasis in breast cancer via miR-146a to activate cancer associated fibroblasts in tumor microenvironment

Shanshan Yang, +7 more

- 15 Jun 2020 -

Experimental Cell Research

TL;DR: BC-derived exosomes promote the activation of CAFs through miR-146a/TXNIP axis to activate Wnt pathway, which in turn enhances invasion and metastasis of BC cells.

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Journal ArticleDOI

Exosomes as a next-generation drug delivery system: An update on drug loading approaches, characterization, and clinical application challenges.

Fatemeh Mehryab, +6 more

- 01 Sep 2020 -

Acta Biomaterialia

TL;DR: While the application of exosomes as a drug delivery system is still in its infancy, they are considered to be a new class of natural nanocarriers with great potential for clinical application and understanding of their key formulation parameters, pharmaceutical properties, in vivo behavior and applicable scale-up production will pave their way to the market.

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References

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Journal ArticleDOI

Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers

Johan Skog, +9 more

- 01 Dec 2008 -

Nature Cell Biology

TL;DR: Tumour-derived microvesicles may provide diagnostic information and aid in therapeutic decisions for cancer patients through a blood test by incorporating an mRNA for a reporter protein into them, and it is demonstrated that messages delivered by microvesicle are translated by recipient cells.

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Journal ArticleDOI

Cancer Invasion and the Microenvironment: Plasticity and Reciprocity

Peter Friedl, +4 more

- 23 Nov 2011 -

Cell

TL;DR: The cell-matrix and cell-cell adhesion, protease, and cytokine systems that underlie tissue invasion by cancer cells are described and explained to explain how the reciprocal reprogramming of both the tumor cells and the surrounding tissue structures not only guides invasion, but also generates diverse modes of dissemination.

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Journal ArticleDOI

Vimentin in cancer and its potential as a molecular target for cancer therapy.

Arun Satelli, +1 more

- 03 Jun 2011 -

Cellular and Molecular Life Sciences

TL;DR: By virtue of its overexpression in cancer and its association with tumor growth and metastasis, vimentin serves as an attractive potential target for cancer therapy; however, more research would be crucial to evaluate its specific role in cancer.

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Journal ArticleDOI

Discovery of Endothelial to Mesenchymal Transition as a Source for Carcinoma-Associated Fibroblasts

Elisabeth M. Zeisberg, +4 more

- 01 Nov 2007 -

Cancer Research

TL;DR: It is shown that transforming growth factor-beta1 could induce proliferating endothelial cells to undergo a phenotypic conversion into fibroblast-like cells and EndMT is a unique mechanism for the accumulation of carcinoma-associated fibroblasts and suggested that antiangiogenic treatment of tumors may have a direct effect in decreasing activated fibro Blasts that likely facilitate cancer progression.

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Journal ArticleDOI

The Control of Vascular Integrity by Endothelial Cell Junctions: Molecular Basis and Pathological Implications

Elisabetta Dejana, +3 more

- 17 Feb 2009 -

Developmental Cell

TL;DR: This review discusses recent findings derived from basic cell biology, clinical studies, and studies in animal models such as mice and zebrafish and their possible integration in a common picture of human pathologies.

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