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Caspases in Cell Death, Inflammation, and Disease

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TLDR
Current understanding of caspase biology is reviewed with a prime focus on the inflammatory caspases and important topics for future experimentation are outlined.
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This article is published in Immunity.The article was published on 2019-06-18 and is currently open access. It has received 582 citations till now. The article focuses on the topics: Caspase & Pyroptosis.

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Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)

Andrea Cossarizza, +462 more
TL;DR: These guidelines are a consensus work of a considerable number of members of the immunology and flow cytometry community providing the theory and key practical aspects offlow cytometry enabling immunologists to avoid the common errors that often undermine immunological data.
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Caspases in Cell Death, Inflammation, and Pyroptosis

TL;DR: This review focuses on mechanisms governing caspases activation and programmed cell death with special emphasis on the recent progress in caspase cross talk and caspasing-driven gasdermin D-induced pyroptosis.
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Emerging connectivity of programmed cell death pathways and its physiological implications

TL;DR: The intriguing notion that the different types of PCD could be seen as a single, coordinated cell death system, in which the individual pathways are highly interconnected and can flexibly compensate for one another is discussed.
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Oxidative stress and diabetic retinopathy: Molecular mechanisms, pathogenetic role and therapeutic implications.

TL;DR: The abnormalities correlated with oxidative stress provide multiple potential therapeutic targets to develop safe and effective treatments for diabetic retinopathy and are summarized.
References
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Journal ArticleDOI

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

TL;DR: Gasdermin D (Gsdmd) is identified by genome-wide clustered regularly interspaced palindromic repeat-Cas9 nuclease screens of caspase-11- and caspasing-1-mediated pyroptosis in mouse bone marrow macrophages to offer insight into inflammasome-mediated immunity/diseases and change the understanding of pyroPTosis and programmed necrosis.
Journal ArticleDOI

Non-canonical inflammasome activation targets caspase-11

TL;DR: It is shown, with C57BL/6 Casp11 gene-targeted mice, that caspase-11 is critical for casp enzyme-1 activation and IL-1β production in macrophages infected with Escherichia coli, Citrobacter rodentium or Vibrio cholerae, and a unique pro-inflammatory role for casingase- 11 in the innate immune response to clinically significant bacterial infections is highlighted.
Journal ArticleDOI

Mechanisms and Functions of Inflammasomes

TL;DR: This Review summarizes recent insights into inflammasome biology and discusses the questions that remain in the field.
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Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

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