A global reference for human genetic variation.
Adam Auton,Gonçalo R. Abecasis,David Altshuler,Richard Durbin,David R. Bentley,Aravinda Chakravarti,Andrew G. Clark,Peter Donnelly,Evan E. Eichler,Paul Flicek,Stacey Gabriel,Richard A. Gibbs,Eric D. Green,Matthew E. Hurles,Bartha Maria Knoppers,Jan O. Korbel,Eric S. Lander,Charles Lee,Hans Lehrach,Elaine R. Mardis,Gabor T. Marth,Gil McVean,Deborah A. Nickerson,Jeanette Schmidt,Stephen T. Sherry,Jun Wang,Richard K. Wilson,Eric Boerwinkle,Harsha Doddapaneni,Yi Han,Viktoriya Korchina,Christie Kovar,Sandra L. Lee,Donna M. Muzny,Jeffrey G. Reid,Yiming Zhu,Yuqi Chang,Qiang Feng,Qiang Feng,Xiaodong Fang,Xiaodong Fang,Xiaosen Guo,Xiaosen Guo,Min Jian,Min Jian,Hui Jiang,Hui Jiang,Xin Jin,Tianming Lan,Guoqing Li,Jingxiang Li,Yingrui Li,Shengmao Liu,Xiao Liu,Xiao Liu,Yao Lu,Xuedi Ma,Meifang Tang,Bo Wang,Guangbiao Wang,Honglong Wu,Renhua Wu,Xun Xu,Ye Yin,Dandan Zhang,Wenwei Zhang,Jiao Zhao,Meiru Zhao,Xiaole Zheng,Namrata Gupta,Neda Gharani,Lorraine Toji,Norman P. Gerry,Alissa M. Resch,Jonathan Barker,Laura Clarke,Laurent Gil,Sarah E. Hunt,Gavin Kelman,Eugene Kulesha,Rasko Leinonen,William M. McLaren,Rajesh Radhakrishnan,Asier Roa,Dmitriy Smirnov,Richard Smith,Ian Streeter,Anja Thormann,Iliana Toneva,Brendan Vaughan,Xiangqun Zheng-Bradley,Russell J. Grocock,Sean Humphray,Terena James,Zoya Kingsbury,Ralf Sudbrak,M. Albrecht,Vyacheslav Amstislavskiy,Tatiana A. Borodina,Matthias Lienhard,Florian Mertes,Marc Sultan,Bernd Timmermann,Marie-Laure Yaspo,Lucinda Fulton,Victor Ananiev,Zinaida Belaia,Dimitriy Beloslyudtsev,Nathan Bouk,Chao Chen,Deanna M. Church,Robert M. Cohen,Charles Cook,John Garner,Timothy Hefferon,Mikhail Kimelman,Chunlei Liu,John Lopez,Peter Meric,Chris O’Sullivan,Yuri Ostapchuk,Lon Phan,Sergiy Ponomarov,Valerie A. Schneider,Eugene Shekhtman,Karl Sirotkin,Douglas J. Slotta,Hua Zhang,Senduran Balasubramaniam,John Burton,Petr Danecek,Thomas M. Keane,Anja Kolb-Kokocinski,Shane A. McCarthy,James Stalker,Michael A. Quail,Christopher Davies,Jeremy Gollub,Teresa Webster,Brant Wong,Yiping Zhan,Christopher L. Campbell,Yu Kong,Anthony Marcketta,Fuli Yu,Lilian Antunes,Matthew N. Bainbridge,Aniko Sabo,Zhuoyi Huang,Lachlan J. M. Coin,Lin Fang,Lin Fang,Qibin Li,Zhenyu Li,Haoxiang Lin,Binghang Liu,Ruibang Luo,Haojing Shao,Haojing Shao,Yinlong Xie,Chen Ye,Chang Yu,Fan Zhang,Hancheng Zheng,Zhu Hongmei,Can Alkan,Elif Dal,Fatma Kahveci,Erik Garrison,Deniz Kural,Wan-Ping Lee,Wen Fung Leong,Michael Strömberg,Alistair Ward,Jiantao Wu,Mengyao Zhang,Mark J. Daly,Mark A. DePristo,Robert E. Handsaker,Robert E. Handsaker,Eric Banks,Gaurav Bhatia,Guillermo del Angel,Giulio Genovese,Heng Li,Seva Kashin,Seva Kashin,Steven A. McCarroll,Steven A. McCarroll,James Nemesh,Ryan Poplin,Seungtai Yoon,Jayon Lihm,Vladimir Makarov,Srikanth Gottipati,Alon Keinan,Juan L. Rodriguez-Flores,Tobias Rausch,Markus Hsi-Yang Fritz,Adrian M. Stütz,Kathryn Beal,Avik Datta,Javier Herrero,Graham R. S. Ritchie,Daniel R. Zerbino,Pardis C. Sabeti,Pardis C. Sabeti,Ilya Shlyakhter,Ilya Shlyakhter,Stephen F. Schaffner,Stephen F. Schaffner,Joseph J. Vitti,Joseph J. Vitti,David Neil Cooper,Edward V. Ball,Peter D. Stenson,Bret Barnes,Markus J. Bauer,R. Keira Cheetham,Anthony J. Cox,Michael A. Eberle,Scott Kahn,Lisa Murray,John F. Peden,Richard Shaw,Eimear E. Kenny,Mark A. Batzer,Miriam K. Konkel,Jerilyn A. Walker,Daniel G. MacArthur,Monkol Lek,Ralf Herwig,Li Ding,Daniel C. Koboldt,David E. Larson,Kai Ye,Simon Gravel,Anand Swaroop,Emily Y. Chew,Tuuli Lappalainen,Yaniv Erlich,Melissa Gymrek,Melissa Gymrek,Thomas Willems,Jared T. Simpson,Mark D. Shriver,Jeffrey A. Rosenfeld,Carlos Bustamante,Stephen B. Montgomery,Francisco M. De La Vega,Jake K. Byrnes,Andrew Carroll,Marianne K. DeGorter,Phil Lacroute,Brian K. Maples,Alicia R. Martin,Andrés Moreno-Estrada,Andrés Moreno-Estrada,Suyash Shringarpure,Fouad Zakharia,Eran Halperin,Eran Halperin,Yael Baran,Eliza Cerveira,Jaeho Hwang,Ankit Malhotra,Dariusz Plewczynski,Kamen Radew,Mallory Romanovitch,Chengsheng Zhang,Fiona Hyland,David Craig,Alexis Christoforides,Nils Homer,Tyler Izatt,Ahmet Kurdoglu,Shripad Sinari,Kevin Squire,Chunlin Xiao,Jonathan Sebat,Danny Antaki,Madhusudan Gujral,Amina Noor,Kenny Ye,Esteban G. Burchard,Ryan D. Hernandez,Christopher R. Gignoux,David Haussler,David Haussler,Sol Katzman,W. James Kent,Bryan Howie,Andres Ruiz-Linares,Emmanouil T. Dermitzakis,Emmanouil T. Dermitzakis,Scott E. Devine,Hyun Min Kang,Jeffrey M. Kidd,Thomas W. Blackwell,Sean Caron,Wei Chen,S. Emery,Lars G. Fritsche,Christian Fuchsberger,Goo Jun,Goo Jun,Bingshan Li,Robert H. Lyons,Chris Scheller,Carlo Sidore,Carlo Sidore,Carlo Sidore,Shiya Song,Elzbieta Sliwerska,Daniel Taliun,Adrian Tan,Ryan P. Welch,Mary Kate Wing,Xiaowei Zhan,Philip Awadalla,Philip Awadalla,Alan Hodgkinson,Yun Li,Xinghua Shi,Andrew Quitadamo,Gerton Lunter,Jonathan Marchini,Simon Myers,Claire Churchhouse,Olivier Delaneau,Olivier Delaneau,Anjali Gupta-Hinch,Warren W. Kretzschmar,Zamin Iqbal,Iain Mathieson,Androniki Menelaou,Androniki Menelaou,Andy Rimmer,Dionysia Kiara Xifara,Taras K. Oleksyk,Yunxin Fu,Xiaoming Liu,Momiao Xiong,Lynn B. Jorde,David J. Witherspoon,Jinchuan Xing,Brian L. Browning,Sharon R. Browning,Fereydoun Hormozdiari,Peter H. Sudmant,Ekta Khurana,Chris Tyler-Smith,Cornelis A. Albers,Qasim Ayub,Yuan Chen,Vincenza Colonna,Vincenza Colonna,Luke Jostins,Klaudia Walter,Yali Xue,Mark Gerstein,Alexej Abyzov,Suganthi Balasubramanian,Jieming Chen,Declan Clarke,Yao Fu,Arif Harmanci,Mike Jin,Dong-Hoon Lee,Jeremy Liu,Xinmeng Jasmine Mu,Xinmeng Jasmine Mu,Jing Zhang,Yan Zhang,Christopher Hartl,Khalid Shakir,Jeremiah D. Degenhardt,Sascha Meiers,Benjamin Raeder,Francesco Paolo Casale,Oliver Stegle,Eric-Wubbo Lameijer,Ira M. Hall,Vineet Bafna,Jacob J. Michaelson,Eugene J. Gardner,Ryan E. Mills,Gargi Dayama,Ken Chen,Xian Fan,Zechen Chong,Tenghui Chen,Mark Chaisson,John Huddleston,Maika Malig,Bradley J. Nelson,Nicholas F. Parrish,Ben Blackburne,Sarah J. Lindsay,Zemin Ning,Yujun Zhang,Hugo Y. K. Lam,Cristina Sisu,Danny Challis,Uday S. Evani,James T. Lu,Uma Nagaswamy,Jin Yu,Wangshen Li,Lukas Habegger,Haiyuan Yu,Fiona Cunningham,Ian Dunham,Kasper Lage,Kasper Lage,Jakob Berg Jespersen,Jakob Berg Jespersen,Jakob Berg Jespersen,Heiko Horn,Heiko Horn,Donghoon Kim,Rob DeSalle,Apurva Narechania,Melissa A. Wilson Sayres,Fernando L. Mendez,G. David Poznik,Peter A. Underhill,David Mittelman,Ruby Banerjee,Maria Cerezo,Thomas W. Fitzgerald,Sandra Louzada,Andrea Massaia,Fengtang Yang,Divya Kalra,Walker Hale,Xu Dan,Kathleen C. Barnes,Christine Beiswanger,Hongyu Cai,Hongzhi Cao,Hongzhi Cao,Brenna M. Henn,Danielle Jones,Jane Kaye,Alastair Kent,Angeliki Kerasidou,Rasika A. Mathias,Pilar N. Ossorio,Michael Parker,Charles N. Rotimi,Charmaine D.M. Royal,Karla Sandoval,Yeyang Su,Zhongming Tian,Sarah A. Tishkoff,Marc Via,Yuhong Wang,Huanming Yang,Ling Yang,Jiayong Zhu,Walter F. Bodmer,Gabriel Bedoya,Zhiming Cai,Yang Gao,Jiayou Chu,Leena Peltonen,Andrés C. García-Montero,Alberto Orfao,Julie Dutil,Juan Carlos Martínez-Cruzado,R. Mathias,Anselm Hennis,Harold Watson,Colin A. McKenzie,Firdausi Qadri,Regina C. LaRocque,Xiaoyan Deng,Danny Asogun,Onikepe A. Folarin,Christian T. Happi,Omonwunmi Omoniwa,Matt Stremlau,Matt Stremlau,Ridhi Tariyal,Ridhi Tariyal,M Jallow,M Jallow,Fatoumatta Sisay Joof,Fatoumatta Sisay Joof,Tumani Corrah,Tumani Corrah,Kirk A. Rockett,Kirk A. Rockett,Dominic P. Kwiatkowski,Dominic P. Kwiatkowski,Jaspal S. Kooner,Tran Tinh Hien,Sarah J. Dunstan,Sarah J. Dunstan,Nguyen ThuyHang,Richard Fonnie,Robert F. Garry,Lansana Kanneh,Lina M. Moses,John S. Schieffelin,Donald S. Grant,Carla Gallo,Giovanni Poletti,Danish Saleheen,Asif Rasheed,Lisa D. Brooks,Adam Felsenfeld,Jean E. McEwen,Yekaterina Vaydylevich,Audrey Duncanson,Michael Dunn,Jeffery A. Schloss +517 more
TLDR
The 1000 Genomes Project set out to provide a comprehensive description of common human genetic variation by applying whole-genome sequencing to a diverse set of individuals from multiple populations, and has reconstructed the genomes of 2,504 individuals from 26 populations using a combination of low-coverage whole-generation sequencing, deep exome sequencing, and dense microarray genotyping.Abstract:
The 1000 Genomes Project set out to provide a comprehensive description of common human genetic variation by applying whole-genome sequencing to a diverse set of individuals from multiple populations. Here we report completion of the project, having reconstructed the genomes of 2,504 individuals from 26 populations using a combination of low-coverage whole-genome sequencing, deep exome sequencing, and dense microarray genotyping. We characterized a broad spectrum of genetic variation, in total over 88 million variants (84.7 million single nucleotide polymorphisms (SNPs), 3.6 million short insertions/deletions (indels), and 60,000 structural variants), all phased onto high-quality haplotypes. This resource includes >99% of SNP variants with a frequency of >1% for a variety of ancestries. We describe the distribution of genetic variation across the global sample, and discuss the implications for common disease studies.read more
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Making new genetic diagnoses with old data: iterative reanalysis and reporting from genome-wide data in 1,133 families with developmental disorders
Caroline F. Wright,Caroline F. Wright,Jeremy F. McRae,Stephen Clayton,Giuseppe Gallone,Stuart Aitken,Tomas W Fitzgerald,Philip Jones,Elena Prigmore,Diana Rajan,Jenny Lord,Alejandro Sifrim,Rosemary Kelsell,Michael Parker,Jeffrey C. Barrett,Matthew E. Hurles,David R. FitzPatrick,Helen V. Firth,Helen V. Firth +18 more
TL;DR: It is estimated that implementing parent–offspring whole-exome sequencing as a first-line diagnostic test for developmental disorders would diagnose >50% of patients, and the importance of coupling large-scale research with clinical practice is highlighted.
Journal ArticleDOI
Ancient genomes document multiple waves of migration in Southeast Asian prehistory
Mark Lipson,Olivia Cheronet,Olivia Cheronet,Swapan Mallick,Swapan Mallick,Nadin Rohland,Marc Oxenham,Michael Pietrusewsky,Thomas Oliver Pryce,Thomas Oliver Pryce,Anna Willis,Hirofumi Matsumura,Hallie R. Buckley,Kate Domett,Giang Hai Nguyen,Hoang Hiep Trinh,Aung Aung Kyaw,Tin Tin Win,Baptiste Pradier,Nasreen Broomandkhoshbacht,Nasreen Broomandkhoshbacht,Francesca Candilio,Piya Changmai,Daniel Fernandes,Daniel Fernandes,Daniel Fernandes,Matthew Ferry,Matthew Ferry,Beatriz Gamarra,Eadaoin Harney,Eadaoin Harney,Jatupol Kampuansai,Wibhu Kutanan,Megan Michel,Megan Michel,Mario Novak,Jonas Oppenheimer,Jonas Oppenheimer,Kendra Sirak,Kendra Sirak,Kristin Stewardson,Kristin Stewardson,Zhao Zhang,Pavel Flegontov,Pavel Flegontov,Ron Pinhasi,Ron Pinhasi,David Reich,David Reich,David Reich +49 more
TL;DR: This paper reported genome-wide ancient DNA data from 18 Southeast Asian individuals spanning from the Neolithic period through the Iron Age (4100 to 1700 years ago) and found that early farmers from Man Bac in Vietnam exhibit a mixture of East Asian (southern Chinese agriculturalist) and deeply diverged eastern Eurasian (hunter-gatherer) ancestry characteristic of Austroasiatic speakers.
Journal ArticleDOI
Proteogenomic and metabolomic characterization of human glioblastoma
Liang-Bo Wang,Alla Karpova,Marina A. Gritsenko,Jennifer E. Kyle,Song Cao,Yize Li,Dmitry Rykunov,Antonio Colaprico,Antonio Colaprico,Joseph H. Rothstein,Runyu Hong,Vasileios Stathias,MacIntosh Cornwell,Francesca Petralia,Yige Wu,Boris Reva,Karsten Krug,Pietro Pugliese,Emily Kawaler,Lindsey K. Olsen,Wen-Wei Liang,Xiaoyu Song,Yongchao Dou,Michael C. Wendl,Wagma Caravan,Wenke Liu,Daniel Cui Zhou,Jiayi Ji,Chia-Feng Tsai,Vladislav A. Petyuk,Jamie Moon,Weiping Ma,Rosalie K. Chu,Karl K. Weitz,Ronald J. Moore,Matthew E. Monroe,Rui Zhao,Xiaolu Yang,Xiaolu Yang,Seungyeul Yoo,Azra Krek,Alexis Demopoulos,Houxiang Zhu,Matthew A. Wyczalkowski,Joshua F. McMichael,Brittany Henderson,Caleb M. Lindgren,Hannah Boekweg,Shuangjia Lu,Jessika Baral,Lijun Yao,Kelly L. Stratton,Lisa M. Bramer,Erika M. Zink,Sneha P. Couvillion,Kent J. Bloodsworth,Shankha Satpathy,Weiva Sieh,Simina M. Boca,Stephan C. Schürer,Feng Chen,Maciej Wiznerowicz,Maciej Wiznerowicz,Karen A. Ketchum,Emily S. Boja,Christopher R. Kinsinger,Ana I. Robles,Tara Hiltke,Mathangi Thiagarajan,Alexey I. Nesvizhskii,Bing Zhang,D. R. Mani,Michele Ceccarelli,Xi Chen,Xi Chen,Sandra Cottingham,Qing Kay Li,Albert H. Kim,David Fenyö,Kelly V. Ruggles,Henry Rodriguez,Mehdi Mesri,Samuel H. Payne,Adam C. Resnick,Pei Wang,Richard D. Smith,Antonio Iavarone,Milan G. Chheda,Jill S. Barnholtz-Sloan,Karin D. Rodland,Karin D. Rodland,Tao Liu,Li Ding,Anupriya Agarwal,Mitual Amin,Eunkyung An,Matthew L. Anderson,David W. Andrews,Thomas L. Bauer,Chet Birger,Michael J. Birrer,Lili Blumenberg,William Bocik,Uma Borate,Melissa Borucki,Meghan C. Burke,Shuang Cai,Anna Calinawan,Steven A. Carr,Sandra Cerda,Daniel W. Chan,Alyssa Charamut,Lin Chen,David Chesla,Arul M. Chinnaiyan,Shrabanti Chowdhury,Marcin Cieślik,David J. Clark,Houston Culpepper,Tomasz Czernicki,Fulvio D'Angelo,Jacob J. Day,Stephanie De Young,Emek Demir,Saravana M. Dhanasekaran,Rajiv Dhir,Marcin J. Domagalski,Brian J. Druker,Elizabeth R. Duffy,Maureen Dyer,Nathan Edwards,Robert Edwards,Kimberly Elburn,Matthew J. Ellis,Jennifer M. Eschbacher,Alicia Francis,Stacey Gabriel,Nikolay Gabrovski,Luciano Garofano,Gad Getz,Michael A. Gillette,Andrew K. Godwin,Denis A. Golbin,Ziad Hanhan,Linda Hannick,Pushpa Hariharan,Barbara Hindenach,Katherine A. Hoadley,Galen Hostetter,Chen Huang,Eric J. Jaehnig,Scott D. Jewell,Nan Ji,Corbin D. Jones,Alcida Karz,Wojciech Kaspera,Lyndon Kim,Ramani B. Kothadia,Chandan Kumar-Sinha,Jonathan T. Lei,Felipe D. Leprevost,Kai Li,Yuxing Liao,Jena Lilly,Hongwei Liu,Jan Lubinski,Rashna Madan,William W. Maggio,Ewa P. Malc,Anna Malovannaya,Sailaja Mareedu,Sanford P. Markey,Annette Marrero-Oliveras,Nina Martinez,Nicollette Maunganidze,Jason E. McDermott,Peter B. McGarvey,John McGee,Piotr A. Mieczkowski,Simona Migliozzi,Francesmary Modugno,Rebecca I. Montgomery,Chelsea J. Newton,Gilbert S. Omenn,Umut Ozbek,Oxana Paklina,Amanda G. Paulovich,Amy M. Perou,Alexander R. Pico,Paul D. Piehowski,Dimitris G. Placantonakis,Larisa Polonskaya,Olga Potapova,Barbara Pruetz,Liqun Qi,Shakti Ramkissoon,Adam C. Resnick,Shannon Richey,Gregory J. Riggins,Karna Robinson,Nancy Roche,Daniel C. Rohrer,Brian R. Rood,Larissa Rossell,Sara R. Savage,Eric E. Schadt,Yan Shi,Zhiao Shi,Yvonne Shutack,Shilpi Singh,Tara Skelly,Lori J. Sokoll,Jakub Stawicki,Stephen E. Stein,James Suh,Wojciech Szopa,Dave Tabor,Donghui Tan,Darlene Tansil,Ratna R. Thangudu,Cristina E. Tognon,Elie Traer,Shirley Tsang,Jeffrey W. Tyner,Ki Sung Um,Dana R. Valley,Suhas Vasaikar,Negin Vatanian,Uma Velvulou,Michael Vernon,Weiqing Wan,Junmei Wang,Alex Webster,Bo Wen,Jeffrey R. Whiteaker,George D. Wilson,Yuriy Zakhartsev,Robert Zelt,Hui Zhang,Liwei Zhang,Zhen Zhang,Grace Zhao,Jun Zhu +242 more
TL;DR: This article identified key phosphorylation events (e.g., phosphorylated PTPN11 and PLCG1) as potential switches mediating oncogenic pathway activation, as well as potential targets for EGFR-, TP53-, and RB1-altered tumors.
Journal ArticleDOI
Early human dispersals within the Americas.
J. Víctor Moreno-Mayar,Lasse Vinner,Peter de Barros Damgaard,Constanza de la Fuente,Jeffrey Chan,Jeffrey P. Spence,Morten E. Allentoft,Tharsika Vimala,Fernando Racimo,Thomaz Pinotti,Simon Rasmussen,Ashot Margaryan,Ashot Margaryan,Miren Iraeta Orbegozo,Dorothea Mylopotamitaki,Matthew J. Wooller,Clement P. Bataille,Lorena Becerra-Valdivia,David Chivall,Daniel Comeskey,Thibaut Devièse,Donald K. Grayson,Len George,Harold Harry,Verner Alexandersen,Charlotte Primeau,Jon M. Erlandson,Claudia Rodrigues-Carvalho,Silvia Reis,Murilo Q.R. Bastos,Jerome S. Cybulski,Jerome S. Cybulski,Carlos Vullo,Flavia Morello,Miguel Vilar,Spencer Wells,Kristian Gregersen,Kasper Lykke Hansen,Niels Lynnerup,Marta Mirazón Lahr,Kurt H. Kjær,André Strauss,André Strauss,Marta P. Alfonso-Durruty,Antonio Salas,Hannes Schroeder,Thomas Higham,Ripan S. Malhi,Jeffrey T. Rasic,Luiz Henrique Souza,Fabrício R. Santos,Anna-Sapfo Malaspinas,Martin Sikora,Rasmus Nielsen,Rasmus Nielsen,Yun S. Song,David J. Meltzer,David J. Meltzer,Eske Willerslev,Eske Willerslev,Eske Willerslev +60 more
TL;DR: Analysis of the oldest genomes suggests that there was an early split within Beringian populations, giving rise to the Northern and Southern lineages, and that the early population spread widely and rapidly suggests that their access to large portions of the hemisphere was essentially unrestricted, yet there are genomic and archaeological hints of an earlier human presence.
Posted ContentDOI
Large-scale association analyses identify host factors influencing human gut microbiome composition
Alexander Kurilshikov,Carolina Medina-Gomez,Rodrigo Bacigalupe,Djawad Radjabzadeh,Jun Wang,Ayse Demirkan,Ayse Demirkan,Caroline I. Le Roy,Juan Antonio Raygoza Garay,Juan Antonio Raygoza Garay,Casey T. Finnicum,Xingrong Liu,Daria V. Zhernakova,Daria V. Zhernakova,Marc Jan Bonder,Tue H. Hansen,Fabian Frost,Malte C. Rühlemann,Williams Turpin,Williams Turpin,Jee-Young Moon,Han-Na Kim,Kreete Lüll,Elad Barkan,Shiraz A. Shah,Myriam Fornage,Joanna Szopinska-Tokov,Zachary D. Wallen,Dmitrii Borisevich,Lars Agréus,Anna Andreasson,Corinna Bang,Larbi Bedrani,Jordana T. Bell,Hans Bisgaard,Michael Boehnke,Dorret I. Boomsma,Robert D. Burk,Annique Claringbould,Kenneth Croitoru,Kenneth Croitoru,Gareth E. Davies,Cornelia M. van Duijn,Cornelia M. van Duijn,Liesbeth Duijts,Gwen Falony,Jingyuan Fu,Adriaan van der Graaf,Torben Hansen,Georg Homuth,David A. Hughes,Richard G. IJzerman,Matthew A. Jackson,Matthew A. Jackson,Vincent W. V. Jaddoe,Marie Joossens,Torben Jørgensen,Daniel Keszthelyi,Rob Knight,Markku Laakso,Matthias Laudes,Lenore J. Launer,Wolfgang Lieb,Aldons J. Lusis,Ad A.M. Masclee,Henriette A. Moll,Zlatan Mujagic,Qi Qibin,Daphna Rothschild,Hocheol Shin,Søren J. Sørensen,Claire J. Steves,Jonathan Thorsen,Nicholas J. Timpson,Raul Y. Tito,Sara Vieira-Silva,Uwe Völker,Henry Völzke,Urmo Võsa,Kaitlin H Wade,Susanna Walter,Kyoko Watanabe,Stefan Weiss,Frank Ulrich Weiss,Omer Weissbrod,Harm-Jan Westra,Gonneke Willemsen,Haydeh Payami,Daisy Jonkers,Alejandro Arias Vasquez,Eco J. C. de Geus,Katie A. Meyer,Jakob Stokholm,Eran Segal,Elin Org,Cisca Wijmenga,Hyung Lae Kim,Robert C. Kaplan,Tim D. Spector,André G. Uitterlinden,Fernando Rivadeneira,Andre Franke,Markus M. Lerch,Lude Franke,Serena Sanna,Serena Sanna,Mauro D'Amato,Oluf Pedersen,Andrew D. Paterson,Robert Kraaij,Jeroen Raes,Alexandra Zhernakova +111 more
TL;DR: A phenome-wide association study and Mendelian randomization identified enrichment of microbiome trait loci in the metabolic, nutrition and environment domains and suggested the microbiome has causal effects in ulcerative colitis and rheumatoid arthritis.
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