A global reference for human genetic variation.
Adam Auton,Gonçalo R. Abecasis,David Altshuler,Richard Durbin,David R. Bentley,Aravinda Chakravarti,Andrew G. Clark,Peter Donnelly,Evan E. Eichler,Paul Flicek,Stacey Gabriel,Richard A. Gibbs,Eric D. Green,Matthew E. Hurles,Bartha Maria Knoppers,Jan O. Korbel,Eric S. Lander,Charles Lee,Hans Lehrach,Elaine R. Mardis,Gabor T. Marth,Gil McVean,Deborah A. Nickerson,Jeanette Schmidt,Stephen T. Sherry,Jun Wang,Richard K. Wilson,Eric Boerwinkle,Harsha Doddapaneni,Yi Han,Viktoriya Korchina,Christie Kovar,Sandra L. Lee,Donna M. Muzny,Jeffrey G. Reid,Yiming Zhu,Yuqi Chang,Qiang Feng,Qiang Feng,Xiaodong Fang,Xiaodong Fang,Xiaosen Guo,Xiaosen Guo,Min Jian,Min Jian,Hui Jiang,Hui Jiang,Xin Jin,Tianming Lan,Guoqing Li,Jingxiang Li,Yingrui Li,Shengmao Liu,Xiao Liu,Xiao Liu,Yao Lu,Xuedi Ma,Meifang Tang,Bo Wang,Guangbiao Wang,Honglong Wu,Renhua Wu,Xun Xu,Ye Yin,Dandan Zhang,Wenwei Zhang,Jiao Zhao,Meiru Zhao,Xiaole Zheng,Namrata Gupta,Neda Gharani,Lorraine Toji,Norman P. Gerry,Alissa M. Resch,Jonathan Barker,Laura Clarke,Laurent Gil,Sarah E. Hunt,Gavin Kelman,Eugene Kulesha,Rasko Leinonen,William M. McLaren,Rajesh Radhakrishnan,Asier Roa,Dmitriy Smirnov,Richard Smith,Ian Streeter,Anja Thormann,Iliana Toneva,Brendan Vaughan,Xiangqun Zheng-Bradley,Russell J. Grocock,Sean Humphray,Terena James,Zoya Kingsbury,Ralf Sudbrak,M. Albrecht,Vyacheslav Amstislavskiy,Tatiana A. Borodina,Matthias Lienhard,Florian Mertes,Marc Sultan,Bernd Timmermann,Marie-Laure Yaspo,Lucinda Fulton,Victor Ananiev,Zinaida Belaia,Dimitriy Beloslyudtsev,Nathan Bouk,Chao Chen,Deanna M. Church,Robert M. Cohen,Charles Cook,John Garner,Timothy Hefferon,Mikhail Kimelman,Chunlei Liu,John Lopez,Peter Meric,Chris O’Sullivan,Yuri Ostapchuk,Lon Phan,Sergiy Ponomarov,Valerie A. Schneider,Eugene Shekhtman,Karl Sirotkin,Douglas J. Slotta,Hua Zhang,Senduran Balasubramaniam,John Burton,Petr Danecek,Thomas M. Keane,Anja Kolb-Kokocinski,Shane A. McCarthy,James Stalker,Michael A. Quail,Christopher Davies,Jeremy Gollub,Teresa Webster,Brant Wong,Yiping Zhan,Christopher L. Campbell,Yu Kong,Anthony Marcketta,Fuli Yu,Lilian Antunes,Matthew N. Bainbridge,Aniko Sabo,Zhuoyi Huang,Lachlan J. M. Coin,Lin Fang,Lin Fang,Qibin Li,Zhenyu Li,Haoxiang Lin,Binghang Liu,Ruibang Luo,Haojing Shao,Haojing Shao,Yinlong Xie,Chen Ye,Chang Yu,Fan Zhang,Hancheng Zheng,Zhu Hongmei,Can Alkan,Elif Dal,Fatma Kahveci,Erik Garrison,Deniz Kural,Wan-Ping Lee,Wen Fung Leong,Michael Strömberg,Alistair Ward,Jiantao Wu,Mengyao Zhang,Mark J. Daly,Mark A. DePristo,Robert E. Handsaker,Robert E. Handsaker,Eric Banks,Gaurav Bhatia,Guillermo del Angel,Giulio Genovese,Heng Li,Seva Kashin,Seva Kashin,Steven A. McCarroll,Steven A. McCarroll,James Nemesh,Ryan Poplin,Seungtai Yoon,Jayon Lihm,Vladimir Makarov,Srikanth Gottipati,Alon Keinan,Juan L. Rodriguez-Flores,Tobias Rausch,Markus Hsi-Yang Fritz,Adrian M. Stütz,Kathryn Beal,Avik Datta,Javier Herrero,Graham R. S. Ritchie,Daniel R. Zerbino,Pardis C. Sabeti,Pardis C. Sabeti,Ilya Shlyakhter,Ilya Shlyakhter,Stephen F. Schaffner,Stephen F. Schaffner,Joseph J. Vitti,Joseph J. Vitti,David Neil Cooper,Edward V. Ball,Peter D. Stenson,Bret Barnes,Markus J. Bauer,R. Keira Cheetham,Anthony J. Cox,Michael A. Eberle,Scott Kahn,Lisa Murray,John F. Peden,Richard Shaw,Eimear E. Kenny,Mark A. Batzer,Miriam K. Konkel,Jerilyn A. Walker,Daniel G. MacArthur,Monkol Lek,Ralf Herwig,Li Ding,Daniel C. Koboldt,David E. Larson,Kai Ye,Simon Gravel,Anand Swaroop,Emily Y. Chew,Tuuli Lappalainen,Yaniv Erlich,Melissa Gymrek,Melissa Gymrek,Thomas Willems,Jared T. Simpson,Mark D. Shriver,Jeffrey A. Rosenfeld,Carlos Bustamante,Stephen B. Montgomery,Francisco M. De La Vega,Jake K. Byrnes,Andrew Carroll,Marianne K. DeGorter,Phil Lacroute,Brian K. Maples,Alicia R. Martin,Andrés Moreno-Estrada,Andrés Moreno-Estrada,Suyash Shringarpure,Fouad Zakharia,Eran Halperin,Eran Halperin,Yael Baran,Eliza Cerveira,Jaeho Hwang,Ankit Malhotra,Dariusz Plewczynski,Kamen Radew,Mallory Romanovitch,Chengsheng Zhang,Fiona Hyland,David Craig,Alexis Christoforides,Nils Homer,Tyler Izatt,Ahmet Kurdoglu,Shripad Sinari,Kevin Squire,Chunlin Xiao,Jonathan Sebat,Danny Antaki,Madhusudan Gujral,Amina Noor,Kenny Ye,Esteban G. Burchard,Ryan D. Hernandez,Christopher R. Gignoux,David Haussler,David Haussler,Sol Katzman,W. James Kent,Bryan Howie,Andres Ruiz-Linares,Emmanouil T. Dermitzakis,Emmanouil T. Dermitzakis,Scott E. Devine,Hyun Min Kang,Jeffrey M. Kidd,Thomas W. Blackwell,Sean Caron,Wei Chen,S. Emery,Lars G. Fritsche,Christian Fuchsberger,Goo Jun,Goo Jun,Bingshan Li,Robert H. Lyons,Chris Scheller,Carlo Sidore,Carlo Sidore,Carlo Sidore,Shiya Song,Elzbieta Sliwerska,Daniel Taliun,Adrian Tan,Ryan P. Welch,Mary Kate Wing,Xiaowei Zhan,Philip Awadalla,Philip Awadalla,Alan Hodgkinson,Yun Li,Xinghua Shi,Andrew Quitadamo,Gerton Lunter,Jonathan Marchini,Simon Myers,Claire Churchhouse,Olivier Delaneau,Olivier Delaneau,Anjali Gupta-Hinch,Warren W. Kretzschmar,Zamin Iqbal,Iain Mathieson,Androniki Menelaou,Androniki Menelaou,Andy Rimmer,Dionysia Kiara Xifara,Taras K. Oleksyk,Yunxin Fu,Xiaoming Liu,Momiao Xiong,Lynn B. Jorde,David J. Witherspoon,Jinchuan Xing,Brian L. Browning,Sharon R. Browning,Fereydoun Hormozdiari,Peter H. Sudmant,Ekta Khurana,Chris Tyler-Smith,Cornelis A. Albers,Qasim Ayub,Yuan Chen,Vincenza Colonna,Vincenza Colonna,Luke Jostins,Klaudia Walter,Yali Xue,Mark Gerstein,Alexej Abyzov,Suganthi Balasubramanian,Jieming Chen,Declan Clarke,Yao Fu,Arif Harmanci,Mike Jin,Dong-Hoon Lee,Jeremy Liu,Xinmeng Jasmine Mu,Xinmeng Jasmine Mu,Jing Zhang,Yan Zhang,Christopher Hartl,Khalid Shakir,Jeremiah D. Degenhardt,Sascha Meiers,Benjamin Raeder,Francesco Paolo Casale,Oliver Stegle,Eric-Wubbo Lameijer,Ira M. Hall,Vineet Bafna,Jacob J. Michaelson,Eugene J. Gardner,Ryan E. Mills,Gargi Dayama,Ken Chen,Xian Fan,Zechen Chong,Tenghui Chen,Mark Chaisson,John Huddleston,Maika Malig,Bradley J. Nelson,Nicholas F. Parrish,Ben Blackburne,Sarah J. Lindsay,Zemin Ning,Yujun Zhang,Hugo Y. K. Lam,Cristina Sisu,Danny Challis,Uday S. Evani,James T. Lu,Uma Nagaswamy,Jin Yu,Wangshen Li,Lukas Habegger,Haiyuan Yu,Fiona Cunningham,Ian Dunham,Kasper Lage,Kasper Lage,Jakob Berg Jespersen,Jakob Berg Jespersen,Jakob Berg Jespersen,Heiko Horn,Heiko Horn,Donghoon Kim,Rob DeSalle,Apurva Narechania,Melissa A. Wilson Sayres,Fernando L. Mendez,G. David Poznik,Peter A. Underhill,David Mittelman,Ruby Banerjee,Maria Cerezo,Thomas W. Fitzgerald,Sandra Louzada,Andrea Massaia,Fengtang Yang,Divya Kalra,Walker Hale,Xu Dan,Kathleen C. Barnes,Christine Beiswanger,Hongyu Cai,Hongzhi Cao,Hongzhi Cao,Brenna M. Henn,Danielle Jones,Jane Kaye,Alastair Kent,Angeliki Kerasidou,Rasika A. Mathias,Pilar N. Ossorio,Michael Parker,Charles N. Rotimi,Charmaine D.M. Royal,Karla Sandoval,Yeyang Su,Zhongming Tian,Sarah A. Tishkoff,Marc Via,Yuhong Wang,Huanming Yang,Ling Yang,Jiayong Zhu,Walter F. Bodmer,Gabriel Bedoya,Zhiming Cai,Yang Gao,Jiayou Chu,Leena Peltonen,Andrés C. García-Montero,Alberto Orfao,Julie Dutil,Juan Carlos Martínez-Cruzado,R. Mathias,Anselm Hennis,Harold Watson,Colin A. McKenzie,Firdausi Qadri,Regina C. LaRocque,Xiaoyan Deng,Danny Asogun,Onikepe A. Folarin,Christian T. Happi,Omonwunmi Omoniwa,Matt Stremlau,Matt Stremlau,Ridhi Tariyal,Ridhi Tariyal,M Jallow,M Jallow,Fatoumatta Sisay Joof,Fatoumatta Sisay Joof,Tumani Corrah,Tumani Corrah,Kirk A. Rockett,Kirk A. Rockett,Dominic P. Kwiatkowski,Dominic P. Kwiatkowski,Jaspal S. Kooner,Tran Tinh Hien,Sarah J. Dunstan,Sarah J. Dunstan,Nguyen ThuyHang,Richard Fonnie,Robert F. Garry,Lansana Kanneh,Lina M. Moses,John S. Schieffelin,Donald S. Grant,Carla Gallo,Giovanni Poletti,Danish Saleheen,Asif Rasheed,Lisa D. Brooks,Adam Felsenfeld,Jean E. McEwen,Yekaterina Vaydylevich,Audrey Duncanson,Michael Dunn,Jeffery A. Schloss +517 more
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TLDR
The 1000 Genomes Project set out to provide a comprehensive description of common human genetic variation by applying whole-genome sequencing to a diverse set of individuals from multiple populations, and has reconstructed the genomes of 2,504 individuals from 26 populations using a combination of low-coverage whole-generation sequencing, deep exome sequencing, and dense microarray genotyping.Abstract:
The 1000 Genomes Project set out to provide a comprehensive description of common human genetic variation by applying whole-genome sequencing to a diverse set of individuals from multiple populations. Here we report completion of the project, having reconstructed the genomes of 2,504 individuals from 26 populations using a combination of low-coverage whole-genome sequencing, deep exome sequencing, and dense microarray genotyping. We characterized a broad spectrum of genetic variation, in total over 88 million variants (84.7 million single nucleotide polymorphisms (SNPs), 3.6 million short insertions/deletions (indels), and 60,000 structural variants), all phased onto high-quality haplotypes. This resource includes >99% of SNP variants with a frequency of >1% for a variety of ancestries. We describe the distribution of genetic variation across the global sample, and discuss the implications for common disease studies.read more
Citations
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Journal ArticleDOI
The MHC locus and genetic susceptibility to autoimmune and infectious diseases
TL;DR: Advances in genetic screens, imputation, and analyses of non-additive and epistatic effects have contributed to a better understanding of the shared and specific roles of MHC variants in different diseases.
Journal ArticleDOI
Excavating Neandertal and Denisovan DNA from the genomes of Melanesian individuals
Benjamin Vernot,Serena Tucci,Serena Tucci,Janet Kelso,Joshua G. Schraiber,Aaron B. Wolf,Rachel M. Gittelman,Michael Dannemann,Steffi Grote,Rajiv C. McCoy,Heather L. Norton,Laura B. Scheinfeldt,David A. Merriwether,George Koki,Jonathan S. Friedlaender,Jon Wakefield,Svante Pääbo,Joshua M. Akey +17 more
TL;DR: This work developed an approach to identify DNA inherited from multiple archaic hominin ancestors and applied it to whole-genome sequences from 1523 geographically diverse individuals, including 35 previously unknown Island Melanesian genomes, and recovered Neandertal and Denisovan DNA.
Journal ArticleDOI
Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology
Niamh Mullins,Andreas J. Forstner,Andreas J. Forstner,Andreas J. Forstner,Kevin S. O’Connell,Kevin S. O’Connell,Brandon J. Coombes,Jonathan R. I. Coleman,Zhen Qiao,Thomas Damm Als,Thomas Damm Als,Tim B. Bigdeli,Tim B. Bigdeli,Sigrid Børte,Sigrid Børte,Sigrid Børte,Julien Bryois,Alexander W. Charney,Ole Kristian Drange,Michael J. Gandal,Saskia P. Hagenaars,Masashi Ikeda,Nolan Kamitaki,Nolan Kamitaki,Minsoo Kim,Kristi Krebs,Georgia Panagiotaropoulou,Brian M. Schilder,Laura G. Sloofman,Stacy Steinberg,Vassily Trubetskoy,Bendik S. Winsvold,Bendik S. Winsvold,Hong-Hee Won,Liliya Abramova,Kristina Adorjan,Esben Agerbo,Esben Agerbo,Mariam M. Al Eissa,Diego Albani,Ney Alliey-Rodriguez,Ney Alliey-Rodriguez,Adebayo Anjorin,Verneri Antilla,Anastasia Antoniou,Swapnil Awasthi,Ji Hyun Baek,Marie Bækvad-Hansen,Marie Bækvad-Hansen,Nicholas Bass,Michael Bauer,Eva C. Beins,Sarah E. Bergen,Armin Birner,Carsten Bøcker Pedersen,Carsten Bøcker Pedersen,Erlend Bøen,Marco P. Boks,Rosa Bosch,Murielle Brum,Ben Michael Brumpton,Nathalie Brunkhorst-Kanaan,Monika Budde,Jonas Bybjerg-Grauholm,Jonas Bybjerg-Grauholm,William Byerley,Murray J. Cairns,Miquel Casas,Pablo Cervantes,Toni-Kim Clarke,Cristiana Cruceanu,Cristiana Cruceanu,Alfredo B. Cuellar-Barboza,Alfredo B. Cuellar-Barboza,Julie M. Cunningham,David Curtis,David Curtis,Piotr M. Czerski,Anders M. Dale,Nina Dalkner,Friederike Sophie David,Franziska Degenhardt,Franziska Degenhardt,Srdjan Djurovic,Srdjan Djurovic,Amanda Dobbyn,Athanassios Douzenis,Torbjørn Elvsåshagen,Torbjørn Elvsåshagen,Valentina Escott-Price,I. Nicol Ferrier,Alessia Fiorentino,Tatiana Foroud,Liz Forty,Josef Frank,Oleksandr Frei,Oleksandr Frei,Nelson B. Freimer,Nelson B. Freimer,Louise Frisén,Katrin Gade,Katrin Gade,Julie Garnham,Joel Gelernter,Joel Gelernter,Marianne Giørtz Pedersen,Marianne Giørtz Pedersen,Ian R. Gizer,Scott D. Gordon,Katherine Gordon-Smith,Tiffany A. Greenwood,Jakob Grove,Jose Guzman-Parra,Kyooseob Ha,Magnús Haraldsson,Martin Hautzinger,Urs Heilbronner,Dennis Hellgren,Stefan Herms,Stefan Herms,Stefan Herms,Per Hoffmann,Per Hoffmann,Per Hoffmann,Peter Holmans,Laura M. Huckins,Stéphane Jamain,Stéphane Jamain,Jessica S. Johnson,Janos Kalman,Yoichiro Kamatani,James L. Kennedy,Sarah Kittel-Schneider,James A. Knowles,Manolis Kogevinas,Maria Koromina,Thorsten M. Kranz,Henry R. Kranzler,Michiaki Kubo,Ralph W. Kupka,Steven A. Kushner,Catharina Lavebratt,Catharina Lavebratt,Jacob Lawrence,Markus Leber,Heon Jeong Lee,Phil Lee,Shawn Levy,Catrin Lewis,Calwing Liao,Calwing Liao,Susanne Lucae,Martin Lundberg,Martin Lundberg,Donald J. MacIntyre,Sigurdur H. Magnusson,Wolfgang Maier,Adam X. Maihofer,Dolores Malaspina,Eirini Maratou,Lina Martinsson,Manuel Mattheisen,Steven A. McCarroll,Steven A. McCarroll,Nathaniel W. McGregor,Peter McGuffin,James McKay,Helena Medeiros,Sarah E. Medland,Vincent Millischer,Vincent Millischer,Grant W. Montgomery,Jennifer L. Moran,Jennifer L. Moran,Derek W. Morris,Thomas W. Mühleisen,Thomas W. Mühleisen,Niamh L. O'Brien,Claire O'Donovan,Loes M. Olde Loohuis,Loes M. Olde Loohuis,Lilijana Oruc,Sergi Papiol,Antonio F. Pardiñas,Amy Perry,Andrea Pfennig,Evgenia Porichi,James B. Potash,Digby Quested,Digby Quested,Towfique Raj,Mark Hyman Rapaport,J. Raymond DePaulo,Eline J. Regeer,John P. Rice,Fabio Rivas,Margarita Rivera,Julian Roth,Panos Roussos,Douglas M. Ruderfer,Cristina Sánchez-Mora,Eva C. Schulte,Fanny Senner,Sally I. Sharp,Paul D. Shilling,Engilbert Sigurdsson,Lea Sirignano,Claire Slaney,Olav B. Smeland,Olav B. Smeland,Daniel J. Smith,Janet L. Sobell,Christine Søholm Hansen,Christine Søholm Hansen,María Soler Artigas,Anne T. Spijker,Dan J. Stein,John Strauss,Beata Świątkowska,Chikashi Terao,Thorgeir E. Thorgeirsson,Claudio Toma,Claudio Toma,Claudio Toma,Paul A. Tooney,Evangelia-Eirini Tsermpini,Marquis P. Vawter,Helmut Vedder,James T.R. Walters,Stephanie H. Witt,Simon Xi,Wei Xu,Jessica Yang,Allan H. Young,Allan H. Young,Hannah Young,Peter P. Zandi,Hang Zhou,Hang Zhou,Lea Zillich,Rolf Adolfsson,Ingrid Agartz,Ingrid Agartz,Martin Alda,Martin Alda,Lars Alfredsson,Gulja Babadjanova,Lena Backlund,Lena Backlund,Bernhard T. Baune,Bernhard T. Baune,Bernhard T. Baune,Frank Bellivier,Susanne Bengesser,Wade H. Berrettini,Douglas Blackwood,Michael Boehnke,Anders D. Børglum,Anders D. Børglum,Gerome Breen,Vaughan J. Carr,Stanley V. Catts,Aiden Corvin,Nicholas John Craddock,Udo Dannlowski,Dimitris Dikeos,Tõnu Esko,Bruno Etain,Panagiotis Ferentinos,Panagiotis Ferentinos,Mark A. Frye,Janice M. Fullerton,Janice M. Fullerton,Micha Gawlik,Elliot S. Gershon,Fernando S. Goes,Melissa J. Green,Melissa J. Green,Maria Grigoroiu-Serbanescu,Joanna Hauser,Frans Henskens,Jan Hillert,Kyung Sue Hong,David M. Hougaard,David M. Hougaard,Christina M. Hultman,Kristian Hveem,Nakao Iwata,Assen Jablensky,Ian Jones,Lisa Jones,René S. Kahn,John R. Kelsoe,George Kirov,Mikael Landén,Mikael Landén,Marion Leboyer,Marion Leboyer,Cathryn M. Lewis,Qingqin S. Li,Jolanta Lissowska,Christine Lochner,Carmel M. Loughland,Nicholas G. Martin,Nicholas G. Martin,Carol A. Mathews,Fermín Mayoral,Susan L. McElroy,Andrew M. McIntosh,Francis J. McMahon,Ingrid Melle,Ingrid Melle,Patricia T. Michie,Lili Milani,Philip B. Mitchell,Gunnar Morken,Ole Mors,Ole Mors,Preben Bo Mortensen,Bryan J. Mowry,Bertram Müller-Myhsok,Bertram Müller-Myhsok,Richard M. Myers,Benjamin M. Neale,Benjamin M. Neale,Caroline M. Nievergelt,Caroline M. Nievergelt,Merete Nordentoft,Merete Nordentoft,Markus M. Nöthen,Michael Conlon O'Donovan,Ketil J. Oedegaard,Tomas Olsson,Michael John Owen,Sara A. Paciga,C Pantelis,Carlos N. Pato,Michele T. Pato,George P. Patrinos,George P. Patrinos,Roy H. Perlis,Danielle Posthuma,Josep Antoni Ramos-Quiroga,Andreas Reif,Eva Z. Reininghaus,Marta Ribasés,Marcella Rietschel,Stephan Ripke,Stephan Ripke,Stephan Ripke,Guy A. Rouleau,Guy A. Rouleau,Takeo Saito,Ulrich Schall,Martin Schalling,Martin Schalling,Peter R. Schofield,Peter R. Schofield,Thomas G. Schulze,Laura J. Scott,Rodney J. Scott,Alessandro Serretti,Cynthia Shannon Weickert,Cynthia Shannon Weickert,Cynthia Shannon Weickert,Jordan W. Smoller,Jordan W. Smoller,Hreinn Stefansson,Kari Stefansson,Kari Stefansson,Eystein Stordal,Fabian Streit,Patrick F. Sullivan,Patrick F. Sullivan,Gustavo Turecki,Arne E. Vaaler,Eduard Vieta,John B. Vincent,Irwin D. Waldman,Thomas W. Weickert,Thomas W. Weickert,Thomas W. Weickert,Thomas Werge,Naomi R. Wray,John-Anker Zwart,John-Anker Zwart,John-Anker Zwart,Joanna M. Biernacka,John I. Nurnberger,Sven Cichon,Howard J. Edenberg,Howard J. Edenberg,Eli A. Stahl,Eli A. Stahl,Andrew McQuillin,Arianna Di Florio,Arianna Di Florio,Roel A. Ophoff,Ole A. Andreassen,Ole A. Andreassen +399 more
TL;DR: The authors performed a genome-wide association study of 41,917 bipolar disorder cases and 371,549 controls of European ancestry, which identified 64 associated genomic loci, including genes encoding targets of antipsychotics, calcium channel blockers, antiepileptics and anesthetics.
Journal ArticleDOI
Polygenic Risk Score Identifies Subgroup With Higher Burden of Atherosclerosis and Greater Relative Benefit From Statin Therapy in the Primary Prevention Setting
Pradeep Natarajan,Robin Young,Nathan O. Stitziel,Sandosh Padmanabhan,Usman Baber,Roxana Mehran,Samantha Sartori,Valentin Fuster,Dermot F. Reilly,Adam S. Butterworth,Daniel J. Rader,Ian Ford,Naveed Sattar,Sekar Kathiresan +13 more
TL;DR: Those at high genetic risk have a greater burden of subclinical atherosclerosis and derive greater relative and absolute benefit from statin therapy to prevent a first coronary heart disease event.
Journal ArticleDOI
Early farmers from across Europe directly descended from Neolithic Aegeans
Zuzana Hofmanová,Susanne Kreutzer,Garrett Hellenthal,Christian Sell,Yoan Diekmann,David Díez-del-Molino,Lucy van Dorp,Saioa López,Athanasios Kousathanas,Athanasios Kousathanas,Vivian Link,Vivian Link,Karola Kirsanow,Lara M. Cassidy,Rui Martiniano,Melanie Strobel,Amelie Scheu,Amelie Scheu,Kostas Kotsakis,Paul Halstead,Sevi Triantaphyllou,Nina Kyparissi-Apostolika,Dushka Urem-Kotsou,Christina Ziota,Fotini Adaktylou,Shyamalika Gopalan,Dean Bobo,Laura Winkelbach,Jens Blöcher,Martina Unterländer,Christoph Leuenberger,Çiler Çilingiroğlu,Barbara Horejs,Fokke Gerritsen,Stephen Shennan,Daniel G. Bradley,Mathias Currat,Krishna R. Veeramah,Daniel Wegmann,Daniel Wegmann,Mark G. Thomas,Christina Papageorgopoulou,Joachim Burger +42 more
TL;DR: This study demonstrates a direct genetic link between Mediterranean and Central European early farmers and those of Greece and Anatolia, extending the European Neolithic migratory chain all the way back to southwestern Asia.
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