Multiancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions
Paul S. de Vries,Michael R. Brown,Amy R. Bentley,Yun J. Sung,Thomas W. Winkler,Ioanna Ntalla,Karen Schwander,Aldi T. Kraja,Xiuqing Guo,Nora Franceschini,Ching-Yu Cheng,Xueling Sim,Dina Vojinovic,Jennifer E. Huffman,Solomon K. Musani,Changwei Li,Mary F. Feitosa,Melissa A. Richard,Raymond Noordam,Hugues Aschard,Traci M. Bartz,Lawrence F. Bielak,Xuan Deng,Rajkumar Dorajoo,Kurt Lohman,Alisa K. Manning,Tuomo Rankinen,Albert V. Smith,Salman M. Tajuddin,Evangelos Evangelou,Evangelos Evangelou,Mariaelisa Graff,Maris Alver,Mathilde Boissel,Jin-Fang Chai,Xu Chen,Jasmin Divers,Ilaria Gandin,Chuan Gao,Anuj Goel,Yanick Hagemeijer,Sarah E. Harris,Fernando Pires Hartwig,Fernando Pires Hartwig,Meian He,Andrea R. V. R. Horimoto,Fang-Chi Hsu,Anne U. Jackson,Anuradhani Kasturiratne,Pirjo Komulainen,Brigitte Kühnel,Federica Laguzzi,Joseph H. Lee,Jian'an Luan,Leo-Pekka Lyytikäinen,Nana Matoba,Ilja M. Nolte,Maik Pietzner,Muhammad Riaz,Muhammad Riaz,M. Abdullah Said,Robert A. Scott,Tamar Sofer,Tamar Sofer,Alena Stančáková,Fumihiko Takeuchi,Bamidele O. Tayo,Peter J. van der Most,Tibor V. Varga,Yajuan Wang,Erin B. Ware,Wanqing Wen,Lisa R. Yanek,Weihua Zhang,Weihua Zhang,Jing Hua Zhao,Saima Afaq,Najaf Amin,Marzyeh Amini,Dan E. Arking,Tin Aung,Christie M. Ballantyne,Christie M. Ballantyne,Eric Boerwinkle,Eric Boerwinkle,Ulrich Broeckel,Archie Campbell,Mickaël Canouil,Sabanayagam Charumathi,Yii-Der Ida Chen,John M. C. Connell,Ulf de Faire,Lisa de las Fuentes,Renée de Mutsert,H. Janaka de Silva,Jingzhong Ding,Anna F. Dominiczak,Qing Duan,Charles B. Eaton,Ruben N. Eppinga,Jessica D. Faul,Virginia Fisher,Terrence Forrester,Oscar H. Franco,Yechiel Friedlander,Mohsen Ghanbari,Mohsen Ghanbari,Franco Giulianini,Hans J. Grabe,Megan L. Grove,C. Charles Gu,Tamara B. Harris,Sami Heikkinen,Chew-Kiat Heng,Chew-Kiat Heng,Makoto Hirata,James E. Hixson,Barbara V. Howard,Barbara V. Howard,M. Arfan Ikram,David R. Jacobs,W. Craig Johnson,Jost B. Jonas,Jost B. Jonas,Candace M. Kammerer,Tomohiro Katsuya,Chiea Chuen Khor,Chiea Chuen Khor,Tuomas O. Kilpeläinen,Tuomas O. Kilpeläinen,Woon-Puay Koh,Heikki A. Koistinen,Heikki A. Koistinen,Heikki A. Koistinen,Ivana Kolcic,Charles Kooperberg,José Eduardo Krieger,Steve B. Kritchevsky,Michiaki Kubo,Johanna Kuusisto,Timo A. Lakka,Carl D. Langefeld,Claudia Langenberg,Lenore J. Launer,Benjamin Lehne,Rozenn N. Lemaitre,Yize Li,Jingjing Liang,Jianjun Liu,Jianjun Liu,Kiang Liu,Marie Loh,Marie Loh,Tin Louie,Reedik Mägi,Ani Manichaikul,Colin A. McKenzie,Thomas Meitinger,Andres Metspalu,Yuri Milaneschi,Lili Milani,Karen L. Mohlke,Thomas H. Mosley,Kenneth J. Mukamal,Mike A. Nalls,Matthias Nauck,Christopher P. Nelson,Christopher P. Nelson,Nona Sotoodehnia,Jeffrey R. O'Connell,Nicholette D. Palmer,Raha Pazoki,Nancy L. Pedersen,Annette Peters,Patricia A. Peyser,Ozren Polasek,Neil R Poulter,Leslie J. Raffel,Olli T. Raitakari,Olli T. Raitakari,Alexander P. Reiner,Treva Rice,Stephen S. Rich,Antonietta Robino,Jennifer G. Robinson,Lynda M. Rose,Igor Rudan,Carsten Oliver Schmidt,Pamela J. Schreiner,William R. Scott,William R. Scott,Peter S. Sever,Yuan Shi,Stephen Sidney,Mario Sims,Blair H. Smith,Jennifer A. Smith,Harold Snieder,John M. Starr,Konstantin Strauch,Nicholas Y. Q. Tan,Kent D. Taylor,Yik Ying Teo,Yih Chung Tham,André G. Uitterlinden,Diana van Heemst,Dragana Vuckovic,Melanie Waldenberger,Lihua Wang,Yujie Wang,Zhe Wang,Wen Bin Wei,Christine Williams,Gregory P. Wilson,Mary K. Wojczynski,Jie Yao,Bing Yu,Caizheng Yu,Jian-Min Yuan,Wei Zhao,Alan B. Zonderman,Diane M. Becker,Michael Boehnke,Donald W. Bowden,John C. Chambers,Ian J. Deary,Tõnu Esko,Tõnu Esko,Martin Farrall,Paul W. Franks,Barry I. Freedman,Philippe Froguel,Philippe Froguel,Paolo Gasparini,Christian Gieger,Bernardo L. Horta,Yoichiro Kamatani,Norihiro Kato,Jaspal S. Kooner,Markku Laakso,Karin Leander,Terho Lehtimäki,Patrik K. E. Magnusson,Brenda W.J.H. Penninx,Alexandre C. Pereira,Rainer Rauramaa,Nilesh J. Samani,Nilesh J. Samani,James Scott,Xiao-Ou Shu,Pim van der Harst,Lynne E. Wagenknecht,Ya Xing Wang,Nicholas J. Wareham,Hugh Watkins,David R. Weir,Ananda R. Wickremasinghe,Wei Zheng,Paul Elliott,Kari E. North,Claude Bouchard,Michele K. Evans,Vilmundur Gudnason,Ching-Ti Liu,Yongmei Liu,Bruce M. Psaty,Bruce M. Psaty,Paul M. Ridker,Paul M. Ridker,Rob M. van Dam,Rob M. van Dam,Sharon L.R. Kardia,Xiaofeng Zhu,Charles N. Rotimi,Dennis O. Mook-Kanamori,Myriam Fornage,Tanika N. Kelly,Ervin R. Fox,Caroline Hayward,Cornelia M. van Duijn,E. Shyong Tai,Tien Yin Wong,Jingmin Liu,Jerome I. Rotter,W. James Gauderman,Michael A. Province,Patricia B. Munroe,Kenneth Rice,Daniel I. Chasman,Daniel I. Chasman,L. Adrienne Cupples,L. Adrienne Cupples,Dabeeru C. Rao,Alanna C. Morrison +293 more
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In this paper, gene-alcohol interactions were incorporated into a multiancestry genome-wide association study of levels of high-density lipoprotein cholesterol, low-density cholesterol, and triglycerides.Abstract:
A person's lipid profile is influenced by genetic variants and alcohol consumption, but the contribution of interactions between these exposures has not been studied. We therefore incorporated gene-alcohol interactions into a multiancestry genome-wide association study of levels of high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and triglycerides. We included 45 studies in stage 1 (genome-wide discovery) and 66 studies in stage 2 (focused follow-up), for a total of 394,584 individuals from 5 ancestry groups. Analyses covered the period July 2014-November 2017. Genetic main effects and interaction effects were jointly assessed by means of a 2-degrees-of-freedom (df) test, and a 1-df test was used to assess the interaction effects alone. Variants at 495 loci were at least suggestively associated (P < 1 × 10-6) with lipid levels in stage 1 and were evaluated in stage 2, followed by combined analyses of stage 1 and stage 2. In the combined analysis of stages 1 and 2, a total of 147 independent loci were associated with lipid levels at P < 5 × 10-8 using 2-df tests, of which 18 were novel. No genome-wide-significant associations were found testing the interaction effect alone. The novel loci included several genes (proprotein convertase subtilisin/kexin type 5 (PCSK5), vascular endothelial growth factor B (VEGFB), and apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 (APOBEC1) complementation factor (A1CF)) that have a putative role in lipid metabolism on the basis of existing evidence from cellular and experimental models.read more
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Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration
Raymond Noordam,Maxime M Bos,Heming Wang,Thomas W. Winkler,Amy R. Bentley,Tuomas O. Kilpeläinen,Tuomas O. Kilpeläinen,Paul S. de Vries,Yun Ju Sung,Karen Schwander,Brian E. Cade,Alisa K. Manning,Hugues Aschard,Hugues Aschard,Michael R. Brown,Han Chen,Nora Franceschini,Solomon K. Musani,Melissa A. Richard,Dina Vojinovic,Stella Aslibekyan,Traci M. Bartz,Lisa de las Fuentes,Mary F. Feitosa,Andrea R. V. R. Horimoto,Marjan Ilkov,Minjung Kho,Aldi T. Kraja,Changwei Li,Elise Lim,Yongmei Liu,Dennis O. Mook-Kanamori,Tuomo Rankinen,Salman M. Tajuddin,Ashley van der Spek,Zhe Wang,Jonathan Marten,Vincent Laville,Maris Alver,Evangelos Evangelou,Evangelos Evangelou,Maria E. Graff,Meian He,Brigitte Kühnel,Leo-Pekka Lyytikäinen,Pedro Marques-Vidal,Ilja M. Nolte,Nicholette D. Palmer,Rainer Rauramaa,Xiao-Ou Shu,Harold Snieder,Stefan Weiss,Wanqing Wen,Lisa R. Yanek,Correa Adolfo,Christie M. Ballantyne,Christie M. Ballantyne,L.F. Bielak,Nienke R. Biermasz,Eric Boerwinkle,Eric Boerwinkle,Niki Dimou,Gudny Eiriksdottir,Chuan Gao,Sina A. Gharib,Daniel J. Gottlieb,Daniel J. Gottlieb,Daniel J. Gottlieb,José Haba-Rubio,Tamara B. Harris,Sami Heikkinen,Raphael Heinzer,James E. Hixson,Georg Homuth,M. Arfan Ikram,Pirjo Komulainen,José Eduardo Krieger,Jiwon Lee,Jingmin Liu,Kurt Lohman,Annemarie I. Luik,Reedik Mägi,Lisa W. Martin,Thomas Meitinger,Andres Metspalu,Yuri Milaneschi,Mike A. Nalls,Jeffrey R. O'Connell,Annette Peters,Patricia A. Peyser,Olli T. Raitakari,Alexander P. Reiner,Patrick C.N. Rensen,Treva Rice,Stephen S. Rich,Till Roenneberg,Jerome I. Rotter,Pamela J. Schreiner,James M. Shikany,Stephen Sidney,Mario Sims,Colleen M. Sitlani,Tamar Sofer,Tamar Sofer,Konstantin Strauch,Morris A. Swertz,Kent D. Taylor,André G. Uitterlinden,Cornelia M. van Duijn,Cornelia M. van Duijn,Henry Völzke,Melanie Waldenberger,Robert B. Wallance,Ko Willems van Dijk,Caizheng Yu,Alan B. Zonderman,Diane M. Becker,Paul Elliott,Paul Elliott,Tõnu Esko,Tõnu Esko,Christian Gieger,Hans J. Grabe,Timo A. Lakka,Terho Lehtimäki,Kari E. North,Brenda W.J.H. Penninx,Peter Vollenweider,Lynne E. Wagenknecht,Tangchun Wu,Yong-Bing Xiang,Wei Zheng,Donna K. Arnett,Claude Bouchard,Michele K. Evans,Vilmundur Gudnason,Sharon L.R. Kardia,Tanika N. Kelly,Stephen B. Kritchevsky,Ruth J. F. Loos,Alexandre C. Pereira,M. A. Province,Bruce M. Psaty,Bruce M. Psaty,Charles N. Rotimi,Xiaofeng Zhu,Najaf Amin,L. Adrienne Cupples,L. Adrienne Cupples,Myriam Fornage,Ervin F. Fox,Xiuqing Guo,W. James Gauderman,Kenneth Rice,Charles Kooperberg,Patricia B. Munroe,Ching-Ti Liu,Alanna C. Morrison,Dabeeru C. Rao,Diana van Heemst,Susan Redline +160 more
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METAL: fast and efficient meta-analysis of genomewide association scans.
TL;DR: METAL provides a computationally efficient tool for meta-analysis of genome-wide association scans, which is a commonly used approach for improving power complex traits gene mapping studies.
Related Papers (5)
Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program.
Derek Klarin,Derek Klarin,Scott M. Damrauer,Scott M. Damrauer,Kelly Cho,Yan V. Sun,Tanya M. Teslovich,Jacqueline Honerlaw,David R. Gagnon,David R. Gagnon,Scott L. DuVall,Jin Li,Jin Li,Gina M. Peloso,Mark Chaffin,Aeron Small,Aeron Small,Jie Huang,Hua Tang,Julie A. Lynch,Yuk-Lam Ho,Dajiang J. Liu,Connor A. Emdin,Connor A. Emdin,Alexander H. Li,Jennifer E. Huffman,Jennifer Lee,Jennifer Lee,Pradeep Natarajan,Pradeep Natarajan,Rajiv Chowdhury,Danish Saleheen,Danish Saleheen,Marijana Vujkovic,Marijana Vujkovic,Aris Baras,Saiju Pyarajan,Saiju Pyarajan,Emanuele Di Angelantonio,Benjamin M. Neale,Benjamin M. Neale,Aliya Naheed,Amit Khera,Amit Khera,John Danesh,Kyong-Mi Chang,Kyong-Mi Chang,Gonçalo R. Abecasis,Cristen J. Willer,Frederick E. Dewey,David J. Carey,VA Million Veteran Program,VA Million Veteran Program,John Concato,J. Michael Gaziano,J. Michael Gaziano,J. Michael Gaziano,Christopher J. O'Donnell,Christopher J. O'Donnell,Philip S. Tsao,Philip S. Tsao,Sekar Kathiresan,Sekar Kathiresan,Daniel J. Rader,Peter W.F. Wilson,Peter W.F. Wilson,Themistocles L. Assimes,Themistocles L. Assimes +67 more
Biological, clinical and population relevance of 95 loci for blood lipids
Tanya M. Teslovich,Kiran Musunuru,Albert V. Smith,Andrew C. Edmondson,Ioannis M. Stylianou,Masahiro Koseki,James P. Pirruccello,James P. Pirruccello,James P. Pirruccello,Samuli Ripatti,Daniel I. Chasman,Cristen J. Willer,Christopher T. Johansen,Sigrid W. Fouchier,Aaron Isaacs,Gina M. Peloso,Maja Barbalić,Sally L. Ricketts,Joshua C. Bis,Yurii S. Aulchenko,Gudmar Thorleifsson,Mary F. Feitosa,John C. Chambers,Marju Orho-Melander,Olle Melander,Toby Johnson,Xiaohui Li,Xiuqing Guo,Mingyao Li,Yoon Shin Cho,Min Jin Go,Young Jin Kim,Jong-Young Lee,Taesung Park,Kyunga Kim,Xueling Sim,Rick Twee-Hee Ong,Damien C. Croteau-Chonka,Leslie A. Lange,Joshua D. Smith,Kijoung Song,Jing Hua Zhao,Xin Yuan,Jian'an Luan,Claudia Lamina,Andreas Ziegler,Weihua Zhang,Robert Y.L. Zee,Alan F. Wright,Jacqueline C. M. Witteman,James F. Wilson,Gonneke Willemsen,H.-Erich Wichmann,John Whitfield,Dawn M. Waterworth,Nicholas J. Wareham,Gérard Waeber,Peter Vollenweider,Benjamin F. Voight,Benjamin F. Voight,Veronique Vitart,André G. Uitterlinden,Manuela Uda,Jaakko Tuomilehto,John R. Thompson,Toshiko Tanaka,Ida Surakka,Heather M. Stringham,Tim D. Spector,Nicole Soranzo,Nicole Soranzo,Johannes H. Smit,Juha Sinisalo,Kaisa Silander,Eric J.G. Sijbrands,Angelo Scuteri,James Scott,David Schlessinger,Serena Sanna,Veikko Salomaa,Juha Saharinen,Chiara Sabatti,Aimo Ruokonen,Igor Rudan,Lynda M. Rose,Robert Roberts,Mark J. Rieder,Bruce M. Psaty,Peter P. Pramstaller,Irene Pichler,Markus Perola,Brenda W.J.H. Penninx,Nancy L. Pedersen,Cristian Pattaro,Alex N. Parker,Guillaume Paré,Ben A. Oostra,Christopher J. O'Donnell,Markku S. Nieminen,Deborah A. Nickerson,Grant W. Montgomery,Thomas Meitinger,Ruth McPherson,Mark I. McCarthy,Wendy L. McArdle,David Masson,Nicholas G. Martin,Fabio Marroni,Massimo Mangino,Patrik K. E. Magnusson,Gavin Lucas,Robert Luben,Ruth J. F. Loos,Marja-Liisa Lokki,Guillaume Lettre,Claudia Langenberg,Lenore J. Launer,Edward G. Lakatta,Reijo Laaksonen,Kirsten Ohm Kyvik,Florian Kronenberg,Inke R. Koenig,Kay-Tee Khaw,Jaakko Kaprio,Lee M. Kaplan,Åsa Johansson,Marjo-Riitta Järvelin,A. Cecile J.W. Janssens,Erik Ingelsson,Wilmar Igi,G. Kees Hovingh,Jouke-Jan Hottenga,Albert Hofman,Andrew A. Hicks,Christian Hengstenberg,Iris M. Heid,Caroline Hayward,Aki S. Havulinna,Nicholas D. Hastie,Tamara B. Harris,Talin Haritunians,Alistair S. Hall,Ulf Gyllensten,Candace Guiducci,Leif Groop,Leif Groop,Elena Gonzalez,Christian Gieger,Nelson B. Freimer,Luigi Ferrucci,Jeanette Erdmann,Paul Elliott,Kenechi Ejebe,Angela Doering,Anna F. Dominiczak,Serkalem Demissie,Panagiotis Deloukas,Eco J. C. de Geus,Ulf de Faire,Gabriel Crawford,Francis S. Collins,Yii-Der Ida Chen,Mark J. Caulfield,Harry Campbell,Noël P. Burtt,Lori L. Bonnycastle,Dorret I. Boomsma,S. Matthijs Boekholdt,Richard N. Bergman,Inês Barroso,Stefania Bandinelli,Christie M. Ballantyne,Themistocles L. Assimes,Themistocles L. Assimes,Thomas Quertermous,Thomas Quertermous,David Altshuler,David Altshuler,Mark Seielstad,Tien Yin Wong,E-Shyong Tai,Alan B. Feranil,Christopher W. Kuzawa,Christopher W. Kuzawa,Linda S. Adair,Herman A. Taylor,Ingrid B. Borecki,Stacey Gabriel,James G. Wilson,Hilma Holm,Unnur Thorsteinsdottir,Vilmundur Gudnason,Ronald M. Krauss,Karen L. Mohlke,Jose M. Ordovas,Patricia B. Munroe,Jaspal S. Kooner,Alan R. Tall,Robert A. Hegele,John J.P. Kastelein,Eric E. Schadt,Jerome I. Rotter,Eric Boerwinkle,David P. Strachan,Vincent Mooser,Kari Stefansson,Muredach P. Reilly,Nilesh J. Samani,Heribert Schunkert,L. Adrienne Cupples,Manjinder S. Sandhu,Manjinder S. Sandhu,Paul M. Ridker,Daniel J. Rader,Cornelia M. van Duijn,Leena Peltonen,Gonçalo R. Abecasis,Michael Boehnke,Sekar Kathiresan +218 more
Discovery and refinement of loci associated with lipid levels
Cristen J. Willer,Ellen M. Schmidt,Sebanti Sengupta,Gina M. Peloso,Gina M. Peloso,Gina M. Peloso,Stefan Gustafsson,Stavroula Kanoni,Andrea Ganna,Andrea Ganna,Jin Chen,Martin L. Buchkovich,Samia Mora,Jacques S. Beckmann,Jennifer L. Bragg-Gresham,Hsing-Yi Chang,Ayse Demirkan,Heleen M. den Hertog,Ron Do,Louise A. Donnelly,Georg Ehret,Georg Ehret,Tõnu Esko,Tõnu Esko,Mary F. Feitosa,Teresa Ferreira,Krista Fischer,Pierre Fontanillas,Ross M. Fraser,Daniel F. Freitag,Deepti Gurdasani,Deepti Gurdasani,Kauko Heikkilä,Elina Hyppönen,Aaron Isaacs,Anne U. Jackson,Åsa Johansson,Toby Johnson,Marika Kaakinen,Johannes Kettunen,Johannes Kettunen,Marcus E. Kleber,Marcus E. Kleber,Xiaohui Li,Jian'an Luan,Leo-Pekka Lyytikäinen,Patrik K. E. Magnusson,Massimo Mangino,Evelin Mihailov,May E. Montasser,Martina Müller-Nurasyid,Ilja M. Nolte,Jeffrey R. O'Connell,Cameron D. Palmer,Cameron D. Palmer,Markus Perola,Markus Perola,Markus Perola,Ann-Kristin Petersen,Serena Sanna,Richa Saxena,Sonia Shah,Dmitry Shungin,Dmitry Shungin,Carlo Sidore,Carlo Sidore,Ci Song,Ci Song,Rona J. Strawbridge,Ida Surakka,Ida Surakka,Toshiko Tanaka,Tanya M. Teslovich,Gudmar Thorleifsson,Evita G. Van Den Herik,Benjamin F. Voight,Kelly A. Volcik,Lindsay L. Waite,Andrew Wong,Ying Wu,Weihua Zhang,Weihua Zhang,Devin Absher,Gershim Asiki,Inês Barroso,Inês Barroso,Inês Barroso,Latonya F. Been,Jennifer L. Bolton,Lori L. Bonnycastle,Paolo Brambilla,Mary Susan Burnett,Giancarlo Cesana,Maria Dimitriou,Alex S. F. Doney,Angela Döring,Paul Elliott,Paul Elliott,Stephen E. Epstein,Gudmundur I. Eyjolfsson,Bruna Gigante,Mark O. Goodarzi,Harald Grallert,Martha L. Gravito,Christopher J. Groves,Göran Hallmans,Anna-Liisa Hartikainen,Caroline Hayward,Dena G. Hernandez,Andrew A. Hicks,Hilma Holm,Yi Jen Hung,Thomas Illig,Matthew Jones,Pontiano Kaleebu,John J.P. Kastelein,Kay-Tee Khaw,Eric Kim,Norman Klopp,Pirjo Komulainen,Meena Kumari,Claudia Langenberg,Terho Lehtimäki,Shih-Yi Lin,Jaana Lindström,Ruth J. F. Loos,Ruth J. F. Loos,François Mach,Wendy L. McArdle,Christa Meisinger,Braxton D. Mitchell,Gabrielle Müller,Ramaiah Nagaraja,Narisu Narisu,Tuomo Nieminen,Rebecca N. Nsubuga,Isleifur Olafsson,Ken K. Ong,Ken K. Ong,Aarno Palotie,Aarno Palotie,Theodore Papamarkou,Theodore Papamarkou,Theodore Papamarkou,Cristina Pomilla,Cristina Pomilla,Anneli Pouta,Anneli Pouta,Daniel J. Rader,Muredach P. Reilly,Paul M. Ridker,Fernando Rivadeneira,Igor Rudan,Aimo Ruokonen,Nilesh J. Samani,Nilesh J. Samani,Hubert Scharnagl,Janet Seeley,Janet Seeley,Kaisa Silander,Kaisa Silander,Alena Stančáková,Kathleen Stirrups,Amy J. Swift,Laurence Tiret,André G. Uitterlinden,L. Joost van Pelt,Sailaja Vedantam,Sailaja Vedantam,Nicholas W.J. Wainwright,Nicholas W.J. Wainwright,Cisca Wijmenga,Sarah H. Wild,Gonneke Willemsen,Tom Wilsgaard,James F. Wilson,Elizabeth H. Young,Elizabeth H. Young,Jing Hua Zhao,Linda S. Adair,Dominique Arveiler,Themistocles L. Assimes,Stefania Bandinelli,Franklyn I. Bennett,Murielle Bochud,Bernhard O. Boehm,Bernhard O. Boehm,Dorret I. Boomsma,Ingrid B. Borecki,Stefan R. Bornstein,Pascal Bovet,Michel Burnier,Harry Campbell,Aravinda Chakravarti,John C. Chambers,John C. Chambers,John C. Chambers,Yii-Der Ida Chen,Yii-Der Ida Chen,Francis S. Collins,Richard S. Cooper,John Danesh,George Dedoussis,Ulf de Faire,Alan B. Feranil,Jean Ferrières,Luigi Ferrucci,Nelson B. Freimer,Christian Gieger,Leif Groop,Leif Groop,Vilmundur Gudnason,Ulf Gyllensten,Anders Hamsten,Tamara B. Harris,Aroon D. Hingorani,Joel N. Hirschhorn,Joel N. Hirschhorn,Albert Hofman,G. Kees Hovingh,Chao A. Hsiung,Steve E. Humphries,Steven C. Hunt,Kristian Hveem,Carlos Iribarren,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Antti Jula,Mika Kähönen,Jaakko Kaprio,Jaakko Kaprio,Antero Kesäniemi,Mika Kivimäki,Jaspal S. Kooner,Jaspal S. Kooner,Jaspal S. Kooner,Peter J. Koudstaal,Ronald M. Krauss,Diana Kuh,Johanna Kuusisto,Kirsten Ohm Kyvik,Markku Laakso,Timo A. Lakka,Timo A. Lakka,Lars Lind,Cecilia M. Lindgren,Nicholas G. Martin,Winfried März,Winfried März,Winfried März,Mark I. McCarthy,Colin A. McKenzie,Pierre Meneton,Andres Metspalu,Leena Moilanen,Andrew D. Morris,Patricia B. Munroe,Inger Njølstad,Nancy L. Pedersen,Chris Power,Peter P. Pramstaller,Peter P. Pramstaller,Jackie F. Price,Bruce M. Psaty,Bruce M. Psaty,Thomas Quertermous,Rainer Rauramaa,Rainer Rauramaa,Danish Saleheen,Danish Saleheen,Veikko Salomaa,Dharambir K. Sanghera,Jouko Saramies,Peter Schwarz,Wayne Huey-Herng Sheu,Alan R. Shuldiner,Alan R. Shuldiner,Agneta Siegbahn,Tim D. Spector,Kari Stefansson,Kari Stefansson,David P. Strachan,Bamidele O. Tayo,Elena Tremoli,Jaakko Tuomilehto,Matti Uusitupa,Cornelia M. van Duijn,Peter Vollenweider,Lars Wallentin,Nicholas J. Wareham,John Whitfield,Bruce H. R. Wolffenbuttel,Jose M. Ordovas,Jose M. Ordovas,Eric Boerwinkle,Colin N. A. Palmer,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Daniel I. Chasman,Jerome I. Rotter,Paul W. Franks,Paul W. Franks,Paul W. Franks,Samuli Ripatti,Samuli Ripatti,Samuli Ripatti,L. Adrienne Cupples,L. Adrienne Cupples,Manjinder S. Sandhu,Manjinder S. Sandhu,Stephen S. Rich,Michael Boehnke,Panos Deloukas,Sekar Kathiresan,Sekar Kathiresan,Karen L. Mohlke,Erik Ingelsson,Erik Ingelsson,Gonçalo R. Abecasis +319 more
A global reference for human genetic variation.
Adam Auton,Gonçalo R. Abecasis,David Altshuler,Richard Durbin,David R. Bentley,Aravinda Chakravarti,Andrew G. Clark,Peter Donnelly,Evan E. Eichler,Paul Flicek,Stacey Gabriel,Richard A. Gibbs,Eric D. Green,Matthew E. Hurles,Bartha Maria Knoppers,Jan O. Korbel,Eric S. Lander,Charles Lee,Hans Lehrach,Elaine R. Mardis,Gabor T. Marth,Gil McVean,Deborah A. Nickerson,Jeanette Schmidt,Stephen T. Sherry,Jun Wang,Richard K. Wilson,Eric Boerwinkle,Harsha Doddapaneni,Yi Han,Viktoriya Korchina,Christie Kovar,Sandra L. Lee,Donna M. Muzny,Jeffrey G. Reid,Yiming Zhu,Yuqi Chang,Qiang Feng,Qiang Feng,Xiaodong Fang,Xiaodong Fang,Xiaosen Guo,Xiaosen Guo,Min Jian,Min Jian,Hui Jiang,Hui Jiang,Xin Jin,Tianming Lan,Guoqing Li,Jingxiang Li,Yingrui Li,Shengmao Liu,Xiao Liu,Xiao Liu,Yao Lu,Xuedi Ma,Meifang Tang,Bo Wang,Guangbiao Wang,Honglong Wu,Renhua Wu,Xun Xu,Ye Yin,Dandan Zhang,Wenwei Zhang,Jiao Zhao,Meiru Zhao,Xiaole Zheng,Namrata Gupta,Neda Gharani,Lorraine Toji,Norman P. Gerry,Alissa M. Resch,Jonathan Barker,Laura Clarke,Laurent Gil,Sarah E. Hunt,Gavin Kelman,Eugene Kulesha,Rasko Leinonen,William M. McLaren,Rajesh Radhakrishnan,Asier Roa,Dmitriy Smirnov,Richard Smith,Ian Streeter,Anja Thormann,Iliana Toneva,Brendan Vaughan,Xiangqun Zheng-Bradley,Russell J. Grocock,Sean Humphray,Terena James,Zoya Kingsbury,Ralf Sudbrak,M. Albrecht,Vyacheslav Amstislavskiy,Tatiana A. Borodina,Matthias Lienhard,Florian Mertes,Marc Sultan,Bernd Timmermann,Marie-Laure Yaspo,Lucinda Fulton,Victor Ananiev,Zinaida Belaia,Dimitriy Beloslyudtsev,Nathan Bouk,Chao Chen,Deanna M. Church,Robert M. Cohen,Charles Cook,John Garner,Timothy Hefferon,Mikhail Kimelman,Chunlei Liu,John Lopez,Peter Meric,Chris O’Sullivan,Yuri Ostapchuk,Lon Phan,Sergiy Ponomarov,Valerie A. Schneider,Eugene Shekhtman,Karl Sirotkin,Douglas J. Slotta,Hua Zhang,Senduran Balasubramaniam,John Burton,Petr Danecek,Thomas M. Keane,Anja Kolb-Kokocinski,Shane A. McCarthy,James Stalker,Michael A. Quail,Christopher Davies,Jeremy Gollub,Teresa Webster,Brant Wong,Yiping Zhan,Christopher L. Campbell,Yu Kong,Anthony Marcketta,Fuli Yu,Lilian Antunes,Matthew N. Bainbridge,Aniko Sabo,Zhuoyi Huang,Lachlan J. M. Coin,Lin Fang,Lin Fang,Qibin Li,Zhenyu Li,Haoxiang Lin,Binghang Liu,Ruibang Luo,Haojing Shao,Haojing Shao,Yinlong Xie,Chen Ye,Chang Yu,Fan Zhang,Hancheng Zheng,Zhu Hongmei,Can Alkan,Elif Dal,Fatma Kahveci,Erik Garrison,Deniz Kural,Wan-Ping Lee,Wen Fung Leong,Michael Strömberg,Alistair Ward,Jiantao Wu,Mengyao Zhang,Mark J. Daly,Mark A. DePristo,Robert E. Handsaker,Robert E. Handsaker,Eric Banks,Gaurav Bhatia,Guillermo del Angel,Giulio Genovese,Heng Li,Seva Kashin,Seva Kashin,Steven A. McCarroll,Steven A. McCarroll,James Nemesh,Ryan Poplin,Seungtai Yoon,Jayon Lihm,Vladimir Makarov,Srikanth Gottipati,Alon Keinan,Juan L. Rodriguez-Flores,Tobias Rausch,Markus Hsi-Yang Fritz,Adrian M. Stütz,Kathryn Beal,Avik Datta,Javier Herrero,Graham R. S. Ritchie,Daniel R. Zerbino,Pardis C. Sabeti,Pardis C. Sabeti,Ilya Shlyakhter,Ilya Shlyakhter,Stephen F. Schaffner,Stephen F. Schaffner,Joseph J. Vitti,Joseph J. Vitti,David Neil Cooper,Edward V. Ball,Peter D. Stenson,Bret Barnes,Markus J. Bauer,R. Keira Cheetham,Anthony J. Cox,Michael A. Eberle,Scott Kahn,Lisa Murray,John F. Peden,Richard Shaw,Eimear E. Kenny,Mark A. Batzer,Miriam K. Konkel,Jerilyn A. Walker,Daniel G. MacArthur,Monkol Lek,Ralf Herwig,Li Ding,Daniel C. Koboldt,David E. Larson,Kai Ye,Simon Gravel,Anand Swaroop,Emily Y. Chew,Tuuli Lappalainen,Yaniv Erlich,Melissa Gymrek,Melissa Gymrek,Thomas Willems,Jared T. Simpson,Mark D. Shriver,Jeffrey A. Rosenfeld,Carlos Bustamante,Stephen B. Montgomery,Francisco M. De La Vega,Jake K. Byrnes,Andrew Carroll,Marianne K. DeGorter,Phil Lacroute,Brian K. Maples,Alicia R. Martin,Andrés Moreno-Estrada,Andrés Moreno-Estrada,Suyash Shringarpure,Fouad Zakharia,Eran Halperin,Eran Halperin,Yael Baran,Eliza Cerveira,Jaeho Hwang,Ankit Malhotra,Dariusz Plewczynski,Kamen Radew,Mallory Romanovitch,Chengsheng Zhang,Fiona Hyland,David Craig,Alexis Christoforides,Nils Homer,Tyler Izatt,Ahmet Kurdoglu,Shripad Sinari,Kevin Squire,Chunlin Xiao,Jonathan Sebat,Danny Antaki,Madhusudan Gujral,Amina Noor,Kenny Ye,Esteban G. Burchard,Ryan D. Hernandez,Christopher R. Gignoux,David Haussler,David Haussler,Sol Katzman,W. James Kent,Bryan Howie,Andres Ruiz-Linares,Emmanouil T. Dermitzakis,Emmanouil T. Dermitzakis,Scott E. Devine,Hyun Min Kang,Jeffrey M. Kidd,Thomas W. Blackwell,Sean Caron,Wei Chen,S. Emery,Lars G. Fritsche,Christian Fuchsberger,Goo Jun,Goo Jun,Bingshan Li,Robert H. Lyons,Chris Scheller,Carlo Sidore,Carlo Sidore,Carlo Sidore,Shiya Song,Elzbieta Sliwerska,Daniel Taliun,Adrian Tan,Ryan P. Welch,Mary Kate Wing,Xiaowei Zhan,Philip Awadalla,Philip Awadalla,Alan Hodgkinson,Yun Li,Xinghua Shi,Andrew Quitadamo,Gerton Lunter,Jonathan Marchini,Simon Myers,Claire Churchhouse,Olivier Delaneau,Olivier Delaneau,Anjali Gupta-Hinch,Warren W. Kretzschmar,Zamin Iqbal,Iain Mathieson,Androniki Menelaou,Androniki Menelaou,Andy Rimmer,Dionysia Kiara Xifara,Taras K. Oleksyk,Yunxin Fu,Xiaoming Liu,Momiao Xiong,Lynn B. Jorde,David J. Witherspoon,Jinchuan Xing,Brian L. Browning,Sharon R. Browning,Fereydoun Hormozdiari,Peter H. Sudmant,Ekta Khurana,Chris Tyler-Smith,Cornelis A. Albers,Qasim Ayub,Yuan Chen,Vincenza Colonna,Vincenza Colonna,Luke Jostins,Klaudia Walter,Yali Xue,Mark Gerstein,Alexej Abyzov,Suganthi Balasubramanian,Jieming Chen,Declan Clarke,Yao Fu,Arif Harmanci,Mike Jin,Dong-Hoon Lee,Jeremy Liu,Xinmeng Jasmine Mu,Xinmeng Jasmine Mu,Jing Zhang,Yan Zhang,Christopher Hartl,Khalid Shakir,Jeremiah D. Degenhardt,Sascha Meiers,Benjamin Raeder,Francesco Paolo Casale,Oliver Stegle,Eric-Wubbo Lameijer,Ira M. Hall,Vineet Bafna,Jacob J. Michaelson,Eugene J. Gardner,Ryan E. Mills,Gargi Dayama,Ken Chen,Xian Fan,Zechen Chong,Tenghui Chen,Mark Chaisson,John Huddleston,Maika Malig,Bradley J. Nelson,Nicholas F. Parrish,Ben Blackburne,Sarah J. Lindsay,Zemin Ning,Yujun Zhang,Hugo Y. K. Lam,Cristina Sisu,Danny Challis,Uday S. Evani,James T. Lu,Uma Nagaswamy,Jin Yu,Wangshen Li,Lukas Habegger,Haiyuan Yu,Fiona Cunningham,Ian Dunham,Kasper Lage,Kasper Lage,Jakob Berg Jespersen,Jakob Berg Jespersen,Jakob Berg Jespersen,Heiko Horn,Heiko Horn,Donghoon Kim,Rob DeSalle,Apurva Narechania,Melissa A. Wilson Sayres,Fernando L. Mendez,G. David Poznik,Peter A. Underhill,David Mittelman,Ruby Banerjee,Maria Cerezo,Thomas W. Fitzgerald,Sandra Louzada,Andrea Massaia,Fengtang Yang,Divya Kalra,Walker Hale,Xu Dan,Kathleen C. Barnes,Christine Beiswanger,Hongyu Cai,Hongzhi Cao,Hongzhi Cao,Brenna M. Henn,Danielle Jones,Jane Kaye,Alastair Kent,Angeliki Kerasidou,Rasika A. Mathias,Pilar N. Ossorio,Michael Parker,Charles N. Rotimi,Charmaine D.M. Royal,Karla Sandoval,Yeyang Su,Zhongming Tian,Sarah A. Tishkoff,Marc Via,Yuhong Wang,Huanming Yang,Ling Yang,Jiayong Zhu,Walter F. Bodmer,Gabriel Bedoya,Zhiming Cai,Yang Gao,Jiayou Chu,Leena Peltonen,Andrés C. García-Montero,Alberto Orfao,Julie Dutil,Juan Carlos Martínez-Cruzado,R. Mathias,Anselm Hennis,Harold Watson,Colin A. McKenzie,Firdausi Qadri,Regina C. LaRocque,Xiaoyan Deng,Danny Asogun,Onikepe A. Folarin,Christian T. Happi,Omonwunmi Omoniwa,Matt Stremlau,Matt Stremlau,Ridhi Tariyal,Ridhi Tariyal,M Jallow,M Jallow,Fatoumatta Sisay Joof,Fatoumatta Sisay Joof,Tumani Corrah,Tumani Corrah,Kirk A. Rockett,Kirk A. Rockett,Dominic P. Kwiatkowski,Dominic P. Kwiatkowski,Jaspal S. Kooner,Tran Tinh Hien,Sarah J. Dunstan,Sarah J. Dunstan,Nguyen ThuyHang,Richard Fonnie,Robert F. Garry,Lansana Kanneh,Lina M. Moses,John S. Schieffelin,Donald S. Grant,Carla Gallo,Giovanni Poletti,Danish Saleheen,Asif Rasheed,Lisa D. Brooks,Adam Felsenfeld,Jean E. McEwen,Yekaterina Vaydylevich,Audrey Duncanson,Michael Dunn,Jeffery A. Schloss +517 more