Meta-analysis of Genome-Wide Association Studies for Extraversion: Findings from the Genetics of Personality Consortium
Stéphanie Martine van den Berg,Marleen H. M. de Moor,Karin J. H. Verweij,Karin J. H. Verweij,Robert F. Krueger,Michelle Luciano,Alejandro Arias Vasquez,Lindsay K. Matteson,Jaime Derringer,Tõnu Esko,Najaf Amin,Scott D. Gordon,Narelle K. Hansell,Amy B. Hart,Ilkka Seppälä,Jennifer E. Huffman,Bettina Konte,Jari Lahti,Minyoung Lee,Michael B. Miller,Teresa Nutile,Toshiko Tanaka,Alexander Teumer,Alexander Viktorin,Juho Wedenoja,Abdel Abdellaoui,Gonçalo R. Abecasis,Daniel E. Adkins,Arpana Agrawal,Jueri Allik,Jueri Allik,Katja Appel,Timothy B. Bigdeli,Fabio Busonero,Harry Campbell,Paul T. Costa,George Davey Smith,Gail Davies,Harriet de Wit,Jun Ding,Barbara E. Engelhardt,Johan G. Eriksson,Iryna O. Fedko,Luigi Ferrucci,Barbara Franke,Ina Giegling,Richard A. Grucza,Annette M. Hartmann,Andrew C. Heath,Kati Heinonen,Anjali K. Henders,Georg Homuth,Jouke-Jan Hottenga,William G. Iacono,Joost G. E. Janzing,Markus Jokela,Robert Karlsson,John P. Kemp,John P. Kemp,Matthew G. Kirkpatrick,Antti Latvala,Antti Latvala,Terho Lehtimäki,David C. Liewald,Pamela A. F. Madden,Chiara Magri,Patrik K. E. Magnusson,Jonathan Marten,Andrea Maschio,Hamdi Mbarek,Sarah E. Medland,Evelin Mihailov,Yuri Milaneschi,Grant W. Montgomery,Matthias Nauck,Michel G. Nivard,Klaasjan G. Ouwens,Aarno Palotie,Aarno Palotie,Erik Pettersson,Ozren Polasek,Yong Qian,Laura Pulkki-Råback,Olli T. Raitakari,Olli T. Raitakari,Anu Realo,Richard J. Rose,Daniela Ruggiero,Carsten Oliver Schmidt,Wendy S. Slutske,Rossella Sorice,John M. Starr,Beate St Pourcain,Angelina R. Sutin,Angelina R. Sutin,Nicholas J. Timpson,Holly Trochet,Sita H. Vermeulen,Eero Vuoksimaa,Elisabeth Widen,Jasper Wouda,Jasper Wouda,Margaret J. Wright,Lina Zgaga,Lina Zgaga,David J. Porteous,Alessandra Minelli,Abraham A. Palmer,Dan Rujescu,Marina Ciullo,Caroline Hayward,Igor Rudan,Andres Metspalu,Andres Metspalu,Jaakko Kaprio,Jaakko Kaprio,Ian J. Deary,Katri Räikkönen,James F. Wilson,James F. Wilson,Liisa Keltikangas-Järvinen,Laura J. Bierut,John M. Hettema,Hans J. Grabe,Brenda W.J.H. Penninx,Cornelia M. van Duijn,David M. Evans,David Schlessinger,Nancy L. Pedersen,Antonio Terracciano,Matt McGue,Matt McGue,Nicholas G. Martin,Dorret I. Boomsma +133 more
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A large meta-analysis of GWA studies for extraversion in 63,030 subjects in 29 cohorts shows that extraversion is a highly polygenic personality trait, with an architecture possibly different from other complex human traits, including other personality traits.Abstract:
Extraversion is a relatively stable and heritable personality trait associated with numerous psychosocial, lifestyle and health outcomes. Despite its substantial heritability, no genetic variants have been detected in previous genome-wide association (GWA) studies, which may be due to relatively small sample sizes of those studies. Here, we report on a large meta-analysis of GWA studies for extraversion in 63,030 subjects in 29 cohorts. Extraversion item data from multiple personality inventories were harmonized across inventories and cohorts. No genome-wide significant associations were found at the single nucleotide polymorphism (SNP) level but there was one significant hit at the gene level for a long non-coding RNA site (LOC101928162). Genome-wide complex trait analysis in two large cohorts showed that the additive variance explained by common SNPs was not significantly different from zero, but polygenic risk scores, weighted using linkage information, significantly predicted extraversion scores in an independent cohort. These results show that extraversion is a highly polygenic personality trait, with an architecture possibly different from other complex human traits, including other personality traits. Future studies are required to further determine which genetic variants, by what modes of gene action, constitute the heritable nature of extraversion.read more
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Analysis of shared heritability in common disorders of the brain
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Drevets,Ravi Duggirala,Thomas D. Dyer,Susanne Erk,Thomas Espeseth,Denis A. Evans,Iryna O. Fedko,Guillén Fernández,Luigi Ferrucci,Simon E. Fisher,Simon E. Fisher,Debra A. Fleischman,Debra A. Fleischman,Debra A. Fleischman,Ian Ford,Tatiana Foroud,Tatiana Foroud,Peter T. Fox,Clyde Francks,Clyde Francks,Masaki Fukunaga,J. Raphael Gibbs,J. Raphael Gibbs,David C. Glahn,Randy L. Gollub,Harald H H Göring,Hans J. Grabe,Robert C. Green,Robert C. Green,Oliver Gruber,Vilmundur Gudnason,Sebastian Guelfi,Narelle K. Hansell,Narelle K. Hansell,John Hardy,Catharina A. Hartman,Ryota Hashimoto,Ryota Hashimoto,Katrin Hegenscheid,Andreas Heinz,Stephanie Le Hellard,Dena G. Hernandez,Dena G. Hernandez,Dena G. Hernandez,Dirk J. Heslenfeld,Beng-Choon Ho,Pieter J. Hoekstra,Wolfgang Hoffmann,Wolfgang Hoffmann,Albert Hofman,Florian Holsboer,Florian Holsboer,Georg Homuth,Norbert Hosten,Jouke-Jan Hottenga,Hilleke E. Hulshoff Pol,Masashi Ikeda,M. Kamran Ikram,Clifford R. Jack,Mark Jenkinson,Robert Johnson,Erik G. Jönsson,Erik G. Jönsson,J. Wouter Jukema,René S. Kahn,Ryota Kanai,Iwona Kłoszewska,David S. Knopman,Peter Kochunov,John B.J. Kwok,John B.J. Kwok,Stephen M. Lawrie,Herve Lemaitre,Herve Lemaitre,Xinmin Liu,Xinmin Liu,Dan L. Longo,W.T. Longstreth,Oscar L. Lopez,Oscar L. Lopez,Simon Lovestone,Simon Lovestone,Oliver Martinez,Jean-Luc Martinot,Jean-Luc Martinot,Venkata S. Mattay,Venkata S. Mattay,Colm McDonald,Andrew M. McIntosh,Katie L. McMahon,Francis J. McMahon,Patrizia Mecocci,Ingrid Melle,Andreas Meyer-Lindenberg,Sebastian Mohnke,Grant W. Montgomery,Derek W. Morris,Derek W. Morris,Thomas H. Mosley,Thomas W. Mühleisen,Bertram Müller-Myhsok,Bertram Müller-Myhsok,Mike A. Nalls,Matthias Nauck,Matthias Nauck,Thomas E. Nichols,Thomas E. Nichols,Wiro J. Niessen,Wiro J. Niessen,Wiro J. Niessen,Markus M. Nöthen,Markus M. Nöthen,Lars Nyberg,Kazutaka Ohi,Rene L. Olvera,Roel A. Ophoff,Roel A. Ophoff,Massimo Pandolfo,Tomáš Paus,Tomáš Paus,Zdenka Pausova,Zdenka Pausova,Brenda W.J.H. Penninx,G. Bruce Pike,Steven G. Potkin,Bruce M. Psaty,Simone Reppermund,Marcella Rietschel,Joshua L. Roffman,Nina Romanczuk-Seiferth,Jerome I. Rotter,Mina Ryten,Mina Ryten,Ralph L. Sacco,Ralph L. Sacco,Perminder S. Sachdev,Perminder S. Sachdev,Andrew J. Saykin,Andrew J. Saykin,Reinhold Schmidt,Peter R. Schofield,Peter R. Schofield,Sigurdur Sigurdsson,Andrew Simmons,Andrew Simmons,Andrew Simmons,Andrew Singleton,Sanjay M. Sisodiya,Colin Smith,Jordan W. Smoller,Jordan W. Smoller,Hilkka Soininen,Hilkka Soininen,Velandai Srikanth,Vidar M. Steen,David J. Stott,Jessika E. Sussmann,Anbupalam Thalamuthu,Henning Tiemeier,Arthur W. Toga,Bryan J. Traynor,Juan C. Troncoso,Jessica A. Turner,Christophe Tzourio,André G. Uitterlinden,André G. Uitterlinden,Maria C. Valdés Hernández,Marcel P. van der Brug,Aad van der Lugt,Nic J A van der Wee,Cornelia M. van Duijn,Neeltje E.M. van Haren,Dennis van 't Ent,Dennis van 't Ent,Marie-José van Tol,Badri N. Vardarajan,Dick J. Veltman,Meike W. Vernooij,Henry Völzke,Henrik Walter,Joanna M. Wardlaw,Thomas H. Wassink,Michael E. Weale,Daniel R. Weinberger,Michael W. Weiner,Wei Wen,Eric Westman,Tonya White,Tien Yin Wong,Tien Yin Wong,Clinton B. Wright,Clinton B. Wright,H. Ronald Zielke,Alan B. Zonderman,Ian J. Deary,Charles DeCarli,Helena Schmidt,Nicholas G. Martin,Anton J. M. de Craen,Margaret J. Wright,Lenore J. Launer,Gunter Schumann,Myriam Fornage,Barbara Franke,Stéphanie Debette,Stéphanie Debette,Sarah E. Medland,M. Arfan Ikram,Paul M. Thompson +435 more
TL;DR: Variants for intracranial volume were also related to childhood and adult cognitive function, and Parkinson's disease, and were enriched near genes involved in growth pathways, including PI3K-AKT signaling.
Journal ArticleDOI
Personality Correlates of Physical Activity: A Review and Meta-analysis
TL;DR: This review aimed to combine the literature on major personality traits and physical activity alongside providing some meta-analytic summaries of the findings, suggesting that personality andPhysical activity relationships are relatively invariant to these factors.
Novel genetic loci underlying human intracranial volume identified through genome-wide association
Hieab H.H. Adams,Derrek P. Hibar,Vincent Chouraki,Jason L. Stein,Paul A. Nyquist,Miguel E. Rentería,Stella Trompet,Alejandro Arias-Vásquez,Sudha Seshadri,Sylvane Desrivières,Ashley Beecham,Neda Jahanshad,Katharina Wittfeld,Tatiana Foroud +13 more
TL;DR: In this paper, the authors identify the biological underpinnings of intracranial volume and their link to physiological and pathological traits, including PI3K-AKT signaling.
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Controlling the false discovery rate: a practical and powerful approach to multiple testing
Yoav Benjamini,Yosef Hochberg +1 more
TL;DR: In this paper, a different approach to problems of multiple significance testing is presented, which calls for controlling the expected proportion of falsely rejected hypotheses -the false discovery rate, which is equivalent to the FWER when all hypotheses are true but is smaller otherwise.
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A Psychobiological Model of Temperament and Character
TL;DR: A psychobiological model of the structure and development of personality that accounts for dimensions of both temperament and character is described, for the first time, for three dimensions of character that mature in adulthood and influence personal and social effectiveness by insight learning about self-concepts.
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Common SNPs explain a large proportion of the heritability for human height
Jian Yang,Beben Benyamin,Brian P. McEvoy,Scott D. Gordon,Anjali K. Henders,Dale R. Nyholt,Pamela A. F. Madden,Andrew C. Heath,Nicholas G. Martin,Grant W. Montgomery,Michael E. Goddard,Peter M. Visscher +11 more
TL;DR: Evidence is provided that the remaining heritability is due to incomplete linkage disequilibrium between causal variants and genotyped SNPs, exacerbated by causal variants having lower minor allele frequency than the SNPs explored to date.
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A systematic method for clinical description and classification of personality variants: A proposal.
TL;DR: In this article, a method for clinical description and classification of both normal and abnormal personality variants is proposed based on a general biosocial theory of personality, and three dimensions of personality are defined in terms of the basic stimulus-response characteristics of novelty seeking, harm avoidance and reward dependence.