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Hilary K. Finucane

Researcher at Harvard University

Publications -  138
Citations -  29303

Hilary K. Finucane is an academic researcher from Harvard University. The author has contributed to research in topics: Genome-wide association study & Heritability. The author has an hindex of 47, co-authored 125 publications receiving 20851 citations. Previous affiliations of Hilary K. Finucane include University of Tartu & Weizmann Institute of Science.

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Analysis of shared heritability in common disorders of the brain

Verneri Anttila, +720 more
- 22 Jun 2018 - 
TL;DR: It is demonstrated that, in the general population, the personality trait neuroticism is significantly correlated with almost every psychiatric disorder and migraine, and it is shown that both psychiatric and neurological disorders have robust correlations with cognitive and personality measures.
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Reference-based phasing using the Haplotype Reference Consortium panel.

Po-Ru Loh, +16 more
- 01 Nov 2016 - 
TL;DR: A new phasing algorithm, Eagle2, is introduced that attains high accuracy across a broad range of cohort sizes by efficiently leveraging information from large external reference panels (such as the Haplotype Reference Consortium; HRC) using a new data structure based on the positional Burrows-Wheeler transform.
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Efficient Bayesian mixed-model analysis increases association power in large cohorts

Po-Ru Loh, +13 more
- 01 Mar 2015 - 
TL;DR: BOLT-LMM is presented, which requires only a small number of O(MN) time iterations and increases power by modeling more realistic, non-infinitesimal genetic architectures via a Bayesian mixture prior on marker effect sizes.
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Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores

Bjarni J. Vilhjálmsson, +394 more
- 01 Oct 2015 - 
TL;DR: LDpred is introduced, a method that infers the posterior mean effect size of each marker by using a prior on effect sizes and LD information from an external reference panel, and outperforms the approach of pruning followed by thresholding, particularly at large sample sizes.
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Association analysis identifies 65 new breast cancer risk loci

Kyriaki Michailidou, +396 more
- 02 Nov 2017 - 
TL;DR: A genome-wide association study of breast cancer in 122,977 cases and 105,974 controls of European ancestry and 14,068 cases and 13,104 controls of East Asian ancestry finds that heritability of Breast cancer due to all single-nucleotide polymorphisms in regulatory features was 2–5-fold enriched relative to the genome- wide average.