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Per Hoffmann

Researcher at University of Basel

Publications -  286
Citations -  30547

Per Hoffmann is an academic researcher from University of Basel. The author has contributed to research in topics: Genome-wide association study & Single-nucleotide polymorphism. The author has an hindex of 60, co-authored 254 publications receiving 24161 citations. Previous affiliations of Per Hoffmann include University Hospital Bonn & Forschungszentrum Jülich.

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Biological insights from 108 schizophrenia-associated genetic loci

Stephan Ripke, +354 more
- 24 Jul 2014 - 
TL;DR: Associations at DRD2 and several genes involved in glutamatergic neurotransmission highlight molecules of known and potential therapeutic relevance to schizophrenia, and are consistent with leading pathophysiological hypotheses.
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Defining the role of common variation in the genomic and biological architecture of adult human height

Andrew R. Wood, +444 more
- 01 Nov 2014 - 
TL;DR: This article identified 697 variants at genome-wide significance that together explained one-fifth of the heritability for adult height, and all common variants together captured 60% of heritability.
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Analysis of shared heritability in common disorders of the brain

Verneri Anttila, +720 more
- 22 Jun 2018 - 
TL;DR: It is demonstrated that, in the general population, the personality trait neuroticism is significantly correlated with almost every psychiatric disorder and migraine, and it is shown that both psychiatric and neurological disorders have robust correlations with cognitive and personality measures.
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Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores

Bjarni J. Vilhjálmsson, +394 more
- 01 Oct 2015 - 
TL;DR: LDpred is introduced, a method that infers the posterior mean effect size of each marker by using a prior on effect sizes and LD information from an external reference panel, and outperforms the approach of pruning followed by thresholding, particularly at large sample sizes.
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Identification of loci associated with schizophrenia by genome-wide association and follow-up

Michael Conlon O'Donovan, +55 more
- 01 Sep 2008 - 
TL;DR: Meta-analysis provided strongest evidence for association around ZNF804A and this strengthened when the affected phenotype including bipolar disorder included bipolar disorder and the overall pattern of replication was unlikely to occur by chance.