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Jan C. Koch

Researcher at University of Göttingen

Publications -  78
Citations -  13544

Jan C. Koch is an academic researcher from University of Göttingen. The author has contributed to research in topics: Amyotrophic lateral sclerosis & Medicine. The author has an hindex of 28, co-authored 67 publications receiving 10634 citations.

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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy

Daniel J. Klionsky, +1287 more
- 01 Apr 2012 - 
TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Daniel J. Klionsky, +2983 more
- 08 Feb 2021 - 
TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.
Journal ArticleDOI

Mechanisms of acute axonal degeneration in the optic nerve in vivo

Johanna Knöferle, +10 more
- 30 Mar 2010 - 
TL;DR: It is demonstrated that increased postlesional autophagy is calcium dependent and thus mechanistically link autophagosomes and intraaxonal calcium levels and is proposed to be major targets for the manipulation of axonal degeneration in future therapeutic settings.
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Nusinersen in adults with 5q spinal muscular atrophy: a non-interventional, multicentre, observational cohort study

Tim Hagenacker, +34 more
- 01 Apr 2020 - 
TL;DR: Despite the limitations of the observational study design and a slow functional decline throughout the natural disease course, the data provide evidence for the safety and efficacy of nusinersen in the treatment of adults with 5q spinal muscular atrophy, with clinically meaningful improvements in motor function in a real-world cohort.