Marion Schneider

TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: In this article, an international treatment protocol has been developed for FHL and IAHS, which has a high fatality rate, justifying immunomodulatory treatment if the disease is progressive.

TL;DR: The combined results from mutational analysis of 34 families and linkage analysis of a subset of consanguineous families indicate that perforin mutations account for 20%-40% of the F HL cases and the FHL 1 locus on chromosome 9 for approximately 10%, whereas the major part of theFHL cases are caused by mutations in not-yet-identified genes.

TL;DR: This work identifies and characterize the neoplastic cells in LCH with BRAFV600E mutations by applying a mutation-specific marker and demonstrates feasibility for routine screening.

TL;DR: Investigation of the presence and function of complement in bone cells including osteoblasts, mesenchymal stem cells (MSC), and osteoclasts found that complement may modulate the inflammatory response of osteoblastic cells in a pro‐inflammatory environment as well as osteoblast–osteoclast interaction.