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Open AccessJournal ArticleDOI

Herp depletion protects from protein aggregation by up-regulating autophagy.

Clara Quiroga, +13 more
- 01 Dec 2013 - 
- Vol. 1833, Iss: 12, pp 3295-3305
TLDR
It is concluded that Herp operates as a relevant factor in the defense against glucose starvation by modulating autophagy levels, and may have important implications due to the known up-regulation of Herp in pathological states such as brain and heart ischemia, both conditions associated to acute nutritional stress.
About: 
This article is published in Biochimica et Biophysica Acta.The article was published on 2013-12-01 and is currently open access. It has received 33 citations till now. The article focuses on the topics: Protein degradation & Autophagy.

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Citations
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Guidelines for the use and interpretatoin of assays for monitoring autophagy

D. J. Klionsky, +9 more
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Journal ArticleDOI

Getting the better of ER stress

Bertrand Mollereau, +2 more
- 30 Oct 2014 - 
TL;DR: The physiological and pathological functions of the ER are reviewed, with a particular focus on the molecular mechanisms that lead to ER hormesis and cellular protection, and the implications for disease treatment are discussed.
Journal ArticleDOI

Multi-level inhibition of coronavirus replication by chemical ER stress.

Mohammed Samer Shaban, +16 more
- 20 Sep 2021 - 
TL;DR: In this article, the authors showed that pharmacological reprogramming of ER stress pathways can be exploited to suppress CoV replication in different cell types including primary differentiated human bronchial epithelial cells.
Journal ArticleDOI

HERP depletion inhibits zearalenone-induced apoptosis through autophagy activation in mouse ovarian granulosa cells.

Fenglei Chen, +5 more
- 01 Feb 2019 - 
TL;DR: Autophagy and ER stress cooperated in apoptosis induced by ZEA; HERP depletion inhibits ZEA-induced apoptosis of ovarian granulosa cells through autophagy activation and apoptotic pathway inhibition.
Journal ArticleDOI

MiR-9-3p augments apoptosis induced by H2O2 through down regulation of Herpud1 in glioma.

Ling Yang, +4 more
- 21 Apr 2017 - 
TL;DR: Low expression of miR-9-3p results in a high level of Herpud1, which may protect against apoptosis in glioma, which is indicated to be down-regulated in high-grade gliomas compared with non-tumor tissues.
References
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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy

Daniel J. Klionsky, +1287 more
- 01 Apr 2012 - 
TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Journal ArticleDOI

Self-eating and self-killing: crosstalk between autophagy and apoptosis

M. Chiara Maiuri, +5 more
- 01 Sep 2007 - 
TL;DR: The functional relationship between apoptosis and autophagy is complex in the sense that, under certain circumstances,autophagy constitutes a stress adaptation that avoids cell death (and suppresses apoptosis), whereas in other cellular settings, it constitutes an alternative cell-death pathway.
Journal ArticleDOI

The unfolded protein response: controlling cell fate decisions under ER stress and beyond

Claudio Hetz
- 01 Feb 2012 - 
TL;DR: Insight is provided into the regulatory mechanisms and signalling crosstalk of the three branches of the UPR, which are initiated by the stress sensors protein kinase RNA-like ER kinase (PERK), inositol-requiring protein 1α (IRE1α) and activating transcription factor 6 (ATF6).
Journal ArticleDOI

Autophagy and the Integrated Stress Response

Guido Kroemer, +3 more
- 22 Oct 2010 - 
TL;DR: Autophagy is a cell biological process that is a central component of the integrated stress response and can be integrated with other cellular stress responses through parallel stimulation of autophagy and other stress responses by specific stress stimuli.
Journal ArticleDOI

Protein aggregation and neurodegenerative disease.

Christopher A. Ross, +1 more
- 01 Jul 2004 - 
TL;DR: There is increased understanding of the pathways involved in protein aggregation, and some recent clues have emerged as to the molecular mechanisms of cellular toxicity, leading to approaches toward rational therapeutics.
Related Papers (5)

Herp, a New Ubiquitin-like Membrane Protein Induced by Endoplasmic Reticulum Stress

Koichi Kokame, +3 more
- 20 Oct 2000 - 

Role of Herp in the endoplasmic reticulum stress response

Osamu Hori, +11 more
- 01 May 2004 - 

Herp stabilizes neuronal Ca2+ homeostasis and mitochondrial function during endoplasmic reticulum stress.

Sic L. Chan, +7 more
- 02 Jul 2004 - 

Characterization of an ERAD Pathway for Nonglycosylated BiP Substrates, which Require Herp

Yuki Okuda-Shimizu, +1 more
- 30 Nov 2007 - 

Herp enhances ER-associated protein degradation by recruiting ubiquilins

Tae Yeon Kim, +3 more
- 02 May 2008 -