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Journal ArticleDOI

Autophagosome formation--the role of ULK1 and Beclin1-PI3KC3 complexes in setting the stage.

Martina Wirth, +2 more
- 01 Oct 2013 - 
- Vol. 23, Iss: 5, pp 301-309
TLDR
How the mammalian ULK1 and Beclin1 complexes are controlled by post-translational modifications and protein-protein interactions is discussed and data linking these complexes together is highlighted.
About: 
This article is published in Seminars in Cancer Biology.The article was published on 2013-10-01. It has received 218 citations till now. The article focuses on the topics: Autophagy.

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Citations
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Book ChapterDOI

Signalling in Autophagy

Eleftherios Karanasios, +1 more
TL;DR: This chapter will provide an up to date summary of this topic with the identification of the mTOR pathway as the master regulator of autophagy.
Journal ArticleDOI

Autophagy-dependent regulation of MHC-I molecule presentation.

Uxía Gestal-Mato, +1 more
- 01 May 2023 - 
TL;DR: In this paper , the authors discuss the role of autophagy in MHC class I-restricted antigen presentation, elucidating new findings on the crosstalk of autoophagy and ER-mediated MHC-I peptide presentation, dendritic cell-mediated cross-presentation, and also mechanisms governing immune evasion.
Journal ArticleDOI

Inosine attenuates rotenone-induced Parkinson's disease in rats by alleviating the imbalance between autophagy and apoptosis.

A. Abd El-latif, +4 more
- 12 May 2023 - 
TL;DR: In this article , the authors investigated the neuroprotective effects of inosine against rotenone-induced Parkinson's disease in rats and focused on the activation of AMPK-mediated autophagy.
Journal ArticleDOI

Interaction mechanisms between autophagy and ferroptosis: Potential role in colorectal cancer

Xin Qiu, +4 more
- 15 Jul 2023 - 
TL;DR: In this article , the authors reviewed the mechanism of ferroptosis and the progress in the treatment of esophageal cancer (EC) and further elaborate the interaction between the mechanism and immunotherapy.
Journal ArticleDOI

The interplay between tauopathy and aging through interruption of UPR/Nrf2/Autophagy crosstalk in the Alzheimer's disease transgenic experimental models.

J. Amini, +4 more
- 03 May 2023 - 
TL;DR: In this article , the effects of tauopathy on normal brain aging in a Drosophila model of Alzheimer's disease was investigated, and the interplay between aging and human tauR406W (htau)-induced cell stress in fruit flies was investigated.
References
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mTOR Signaling in Growth Control and Disease

Mathieu Laplante, +1 more
TL;DR: The mechanistic target of rapamycin (mTOR) signaling pathway senses and integrates a variety of environmental cues to regulate organismal growth and homeostasis as mentioned in this paper, and is implicated in an increasing number of pathological conditions, including cancer, obesity, type 2 diabetes, and neurodegeneration.
Journal ArticleDOI

Autophagy fights disease through cellular self-digestion

Noboru Mizushima, +3 more
- 28 Feb 2008 - 
TL;DR: Understanding autophagy may ultimately allow scientists and clinicians to harness this process for the purpose of improving human health, and to play a role in cell death.
Journal ArticleDOI

mTOR signaling in growth control and disease.

Mathieu Laplante, +1 more
- 13 Apr 2012 - 
TL;DR: Recent advances in understanding of the mTOR pathway are reviewed and pharmacological approaches to treat human pathologies linked to mTOR deregulation are discussed.
Journal ArticleDOI

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

Joungmok Kim, +3 more
- 01 Feb 2011 - 
TL;DR: A molecular mechanism for regulation of the mammalian autophagy-initiating kinase Ulk1, a homologue of yeast ATG1, is demonstrated and a signalling mechanism for UlK1 regulation and autophagic induction in response to nutrient signalling is revealed.
Journal ArticleDOI

TSC2 mediates cellular energy response to control cell growth and survival.

Ken Inoki, +2 more
- 26 Nov 2003 - 
TL;DR: It is described that TSC2 is regulated by cellular energy levels and plays an essential role in the cellular energy response pathway and its phosphorylation by AMPK protect cells from energy deprivation-induced apoptosis.
Related Papers (5)

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

Joungmok Kim, +3 more
- 01 Feb 2011 - 

Autophagy: Renovation of Cells and Tissues

Noboru Mizushima, +1 more
- 11 Nov 2011 - 

Guidelines for the use and interpretation of assays for monitoring autophagy

Daniel J. Klionsky, +1287 more
- 01 Apr 2012 - 

Autophagy in human health and disease.

Augustine M.K. Choi, +2 more
- 13 Feb 2013 - 

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

Daniel F. Egan, +16 more
- 28 Jan 2011 -