scispace - formally typeset
Journal ArticleDOI

Autophagosome formation--the role of ULK1 and Beclin1-PI3KC3 complexes in setting the stage.

Martina Wirth, +2 more
- 01 Oct 2013 - 
- Vol. 23, Iss: 5, pp 301-309
TLDR
How the mammalian ULK1 and Beclin1 complexes are controlled by post-translational modifications and protein-protein interactions is discussed and data linking these complexes together is highlighted.
About: 
This article is published in Seminars in Cancer Biology.The article was published on 2013-10-01. It has received 218 citations till now. The article focuses on the topics: Autophagy.

read more

Citations
More filters
Journal ArticleDOI

Ubiquitin-mediated regulation of autophagy

Ruey-Hwa Chen, +5 more
- 21 Oct 2019 - 
TL;DR: It is highlighted how dysregulation of ubiquitin-mediated autophagy pathways is associated with a number of human diseases and the potential of targeting these pathways for disease intervention.
Journal ArticleDOI

Regulation of autophagy by protein post-translational modification

Willayat Yousuf Wani, +6 more
- 01 Jan 2015 - 
TL;DR: This work has shown that phosphorylation is so far the most intensively studied post-translational modification in the autophagy process, followed by ubiquitination and acetylation, and an interesting and new area is also now emerging, which appears to complement these more traditional mechanisms, and includes O-GlcNAcylation and redox regulation at thiol residues.
Journal ArticleDOI

Viral Oncology: Molecular Biology and Pathogenesis.

Uyen Ngoc Mui, +2 more
- 29 Nov 2017 - 
TL;DR: In this review, the molecular biology and oncogenic pathways of established human oncoviruses will be discussed and available and emerging therapies for them will be mentioned.
Journal ArticleDOI

Autophagy: A Druggable Process.

Etienne Morel, +6 more
- 06 Jan 2017 - 
TL;DR: Each of these levels of regulation of autophagy in mammalian cells is potentially druggable, and, depending on the indication, may be able to stimulate or inhibit autophagosome maturation and lysosomal degradation.
Journal ArticleDOI

Cannabidiol stimulates Aml-1a-dependent glial differentiation and inhibits glioma stem-like cells proliferation by inducing autophagy in a TRPV2-dependent manner.

Massimo Nabissi, +8 more
- 15 Oct 2015 - 
TL;DR: It is demonstrated that cannabidiol by activating transient receptor potential vanilloid‐2 (TRPV2) triggers GSCs differentiation activating the autophagic process and inhibits G SCs proliferation and clonogenic capability, and CBD and carmustine in combination overcome the high resistance of GSCS to BCNU treatment, by inducing apoptotic cell death.
References
More filters

mTOR Signaling in Growth Control and Disease

Mathieu Laplante, +1 more
TL;DR: The mechanistic target of rapamycin (mTOR) signaling pathway senses and integrates a variety of environmental cues to regulate organismal growth and homeostasis as mentioned in this paper, and is implicated in an increasing number of pathological conditions, including cancer, obesity, type 2 diabetes, and neurodegeneration.
Journal ArticleDOI

Autophagy fights disease through cellular self-digestion

Noboru Mizushima, +3 more
- 28 Feb 2008 - 
TL;DR: Understanding autophagy may ultimately allow scientists and clinicians to harness this process for the purpose of improving human health, and to play a role in cell death.
Journal ArticleDOI

mTOR signaling in growth control and disease.

Mathieu Laplante, +1 more
- 13 Apr 2012 - 
TL;DR: Recent advances in understanding of the mTOR pathway are reviewed and pharmacological approaches to treat human pathologies linked to mTOR deregulation are discussed.
Journal ArticleDOI

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

Joungmok Kim, +3 more
- 01 Feb 2011 - 
TL;DR: A molecular mechanism for regulation of the mammalian autophagy-initiating kinase Ulk1, a homologue of yeast ATG1, is demonstrated and a signalling mechanism for UlK1 regulation and autophagic induction in response to nutrient signalling is revealed.
Journal ArticleDOI

TSC2 mediates cellular energy response to control cell growth and survival.

Ken Inoki, +2 more
- 26 Nov 2003 - 
TL;DR: It is described that TSC2 is regulated by cellular energy levels and plays an essential role in the cellular energy response pathway and its phosphorylation by AMPK protect cells from energy deprivation-induced apoptosis.
Related Papers (5)

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

Joungmok Kim, +3 more
- 01 Feb 2011 - 

Autophagy: Renovation of Cells and Tissues

Noboru Mizushima, +1 more
- 11 Nov 2011 - 

Guidelines for the use and interpretation of assays for monitoring autophagy

Daniel J. Klionsky, +1287 more
- 01 Apr 2012 - 

Autophagy in human health and disease.

Augustine M.K. Choi, +2 more
- 13 Feb 2013 - 

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

Daniel F. Egan, +16 more
- 28 Jan 2011 -