Autophagosome formation--the role of ULK1 and Beclin1-PI3KC3 complexes in setting the stage.

doi:10.1016/J.SEMCANCER.2013.05.007

Journal ArticleDOI

Autophagosome formation--the role of ULK1 and Beclin1-PI3KC3 complexes in setting the stage.

Martina Wirth, +2 more

- 01 Oct 2013 -

Seminars in Cancer Biology

- Vol. 23, Iss: 5, pp 301-309

TLDR

How the mammalian ULK1 and Beclin1 complexes are controlled by post-translational modifications and protein-protein interactions is discussed and data linking these complexes together is highlighted.

About:

This article is published in Seminars in Cancer Biology.The article was published on 2013-10-01. It has received 218 citations till now. The article focuses on the topics: Autophagy.

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The autophagosome: origins unknown, biogenesis complex

Christopher A. Lamb, +2 more

- 01 Dec 2013 -

Nature Reviews Molecular Cell Biology

TL;DR: It is proposed that the isolation membrane forms from the mitochondria-associated endoplasmic reticulum (ER) membrane (MAM) and the role of ATG proteins and the vesicular trafficking machinery in autophagosome formation is proposed.

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Journal ArticleDOI

WIPI2 Links LC3 Conjugation with PI3P, Autophagosome Formation, and Pathogen Clearance by Recruiting Atg12–5-16L1

Hannah C. Dooley, +5 more

- 17 Jul 2014 -

Molecular Cell

TL;DR: Mutation experiments and ectopic localization of WIPI2b to plasma membrane show that WIPi2b is a PtdIns(3)P effector upstream of Atg16L1 and is required for LC3 conjugation and starvation-induced autophagy through recruitment of the Atg12–5- 16L1 complex.

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Journal ArticleDOI

To Be or Not to Be? How Selective Autophagy and Cell Death Govern Cell Fate

Douglas R. Green, +1 more

- 27 Mar 2014 -

Cell

TL;DR: The progress that has been made in the last few decades in determining the fates of damaged organelles and damaged cells through discrete, but genetically overlapping, pathways involving the selective autophagy and cell death machinery is considered.

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Journal ArticleDOI

mTORC1 signaling and the metabolic control of cell growth.

Issam Ben-Sahra, +1 more

- 01 Apr 2017 -

Current Opinion in Cell Biology

TL;DR: As dysregulated mTORC1 underlies a variety of human diseases, including cancer, diabetes, autoimmune diseases, and neurological disorders, understanding the metabolic program downstream of m TORC1 provides insights into its role in these pathological states.

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References

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Journal ArticleDOI

Global analysis of protein phosphorylation in yeast

Jason Ptacek, +24 more

- 01 Dec 2005 -

Nature

TL;DR: In this article, the in vitro substrates recognized by most yeast protein kinases were identified, including closely related kinases of the protein kinase A family and four cyclin-dependent kinases that vary only in their cyclin subunits.

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Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol-3-kinase complex.

Yun Zhong, +8 more

- 08 Mar 2009 -

Nature Cell Biology

TL;DR: It is hypothesized that by forming distinct protein complexes, Beclin 1 and its binding proteins orchestrate the precise function of the class III PI(3)K in regulating autophagy at multiple steps.

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Journal ArticleDOI

FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells

Taichi Hara, +6 more

- 05 May 2008 -

Journal of Cell Biology

TL;DR: The results suggest that FIP200 is a novel mammalian autophagy factor that functions together with ULKs, which regulates diverse cellular functions such as cell size, proliferation, and migration.

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Journal ArticleDOI

Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis.

Yoshinori Takahashi, +11 more

- 23 Sep 2007 -

Nature Cell Biology

TL;DR: It is demonstrated that Bif-1 interacts with Beclin 1 through ultraviolet irradiation resistance-associated gene (UVRAG) and functions as a positive mediator of the class III PI(3) kinase (PI( 3)KC3) and observed that B if-1 ablation prolongs cell survival under starvation conditions.

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Journal ArticleDOI

Starvation and ULK1-dependent cycling of mammalian Atg9 between the TGN and endosomes

Andrew R. J. Young, +8 more

- 15 Sep 2006 -

Journal of Cell Science

TL;DR: The mammalian homologue of Atg9p, a multi-spanning transmembrane protein essential in yeast for autophagy, is studied to gain a better understanding of the function of this ubiquitious protein.

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