Autophagosome formation--the role of ULK1 and Beclin1-PI3KC3 complexes in setting the stage.

doi:10.1016/J.SEMCANCER.2013.05.007

Journal ArticleDOI

Autophagosome formation--the role of ULK1 and Beclin1-PI3KC3 complexes in setting the stage.

Martina Wirth, +2 more

- 01 Oct 2013 -

Seminars in Cancer Biology

- Vol. 23, Iss: 5, pp 301-309

TLDR

How the mammalian ULK1 and Beclin1 complexes are controlled by post-translational modifications and protein-protein interactions is discussed and data linking these complexes together is highlighted.

About:

This article is published in Seminars in Cancer Biology.The article was published on 2013-10-01. It has received 218 citations till now. The article focuses on the topics: Autophagy.

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Dissertation

Investigation of selected autophagic proteins and the effect of tPS1-GFP expression

Mowafag F. Elazzouzi

TL;DR: The suggested interactions between truncated PS1 and mTOR, raptor and LC3 may dysregulate mTOR signalling pathway, prevent recruitment of mTOR substrates by raptor or block the fusion between autophagosomes and lysosomes via LC3.

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Cardiovascular aging: the mitochondrial influence

Shakti Sagar, +1 more

- 17 Jul 2023 -

The journal of cardiovascular aging

TL;DR: In this paper , the authors reviewed the evidence demonstrating the mitochondrial contribution to the cardiac aging process and disease susceptibility, and discussed the potential mechanisms responsible for the age-related decline in mitochondrial function.

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Delineating the twin role of autophagy in lung cancer

Shaoqin Zhang, +1 more

- 30 Apr 2023 -

Biologia futura

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References

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mTOR Signaling in Growth Control and Disease

Mathieu Laplante, +1 more

TL;DR: The mechanistic target of rapamycin (mTOR) signaling pathway senses and integrates a variety of environmental cues to regulate organismal growth and homeostasis as mentioned in this paper, and is implicated in an increasing number of pathological conditions, including cancer, obesity, type 2 diabetes, and neurodegeneration.

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Journal ArticleDOI

Autophagy fights disease through cellular self-digestion

Noboru Mizushima, +3 more

- 28 Feb 2008 -

Nature

TL;DR: Understanding autophagy may ultimately allow scientists and clinicians to harness this process for the purpose of improving human health, and to play a role in cell death.

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Journal ArticleDOI

mTOR signaling in growth control and disease.

Mathieu Laplante, +1 more

- 13 Apr 2012 -

Cell

TL;DR: Recent advances in understanding of the mTOR pathway are reviewed and pharmacological approaches to treat human pathologies linked to mTOR deregulation are discussed.

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Journal ArticleDOI

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

Joungmok Kim, +3 more

- 01 Feb 2011 -

Nature Cell Biology

TL;DR: A molecular mechanism for regulation of the mammalian autophagy-initiating kinase Ulk1, a homologue of yeast ATG1, is demonstrated and a signalling mechanism for UlK1 regulation and autophagic induction in response to nutrient signalling is revealed.

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Journal ArticleDOI

TSC2 mediates cellular energy response to control cell growth and survival.

Ken Inoki, +2 more

- 26 Nov 2003 -

Cell

TL;DR: It is described that TSC2 is regulated by cellular energy levels and plays an essential role in the cellular energy response pathway and its phosphorylation by AMPK protect cells from energy deprivation-induced apoptosis.

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