Autophagosome formation--the role of ULK1 and Beclin1-PI3KC3 complexes in setting the stage.

doi:10.1016/J.SEMCANCER.2013.05.007

Journal ArticleDOI

Autophagosome formation--the role of ULK1 and Beclin1-PI3KC3 complexes in setting the stage.

Martina Wirth, +2 more

- 01 Oct 2013 -

Seminars in Cancer Biology

- Vol. 23, Iss: 5, pp 301-309

TLDR

How the mammalian ULK1 and Beclin1 complexes are controlled by post-translational modifications and protein-protein interactions is discussed and data linking these complexes together is highlighted.

About:

This article is published in Seminars in Cancer Biology.The article was published on 2013-10-01. It has received 218 citations till now. The article focuses on the topics: Autophagy.

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The autophagosome: origins unknown, biogenesis complex

Christopher A. Lamb, +2 more

- 01 Dec 2013 -

Nature Reviews Molecular Cell Biology

TL;DR: It is proposed that the isolation membrane forms from the mitochondria-associated endoplasmic reticulum (ER) membrane (MAM) and the role of ATG proteins and the vesicular trafficking machinery in autophagosome formation is proposed.

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Journal ArticleDOI

WIPI2 Links LC3 Conjugation with PI3P, Autophagosome Formation, and Pathogen Clearance by Recruiting Atg12–5-16L1

Hannah C. Dooley, +5 more

- 17 Jul 2014 -

Molecular Cell

TL;DR: Mutation experiments and ectopic localization of WIPI2b to plasma membrane show that WIPi2b is a PtdIns(3)P effector upstream of Atg16L1 and is required for LC3 conjugation and starvation-induced autophagy through recruitment of the Atg12–5- 16L1 complex.

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Journal ArticleDOI

To Be or Not to Be? How Selective Autophagy and Cell Death Govern Cell Fate

Douglas R. Green, +1 more

- 27 Mar 2014 -

Cell

TL;DR: The progress that has been made in the last few decades in determining the fates of damaged organelles and damaged cells through discrete, but genetically overlapping, pathways involving the selective autophagy and cell death machinery is considered.

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Journal ArticleDOI

mTORC1 signaling and the metabolic control of cell growth.

Issam Ben-Sahra, +1 more

- 01 Apr 2017 -

Current Opinion in Cell Biology

TL;DR: As dysregulated mTORC1 underlies a variety of human diseases, including cancer, diabetes, autoimmune diseases, and neurological disorders, understanding the metabolic program downstream of m TORC1 provides insights into its role in these pathological states.

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References

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A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy.

Carol A. Mercer, +2 more

- 01 Jul 2009 -

Autophagy

TL;DR: The identification of the novel protein, Atg 101, and the validation of Atg13 and Atg101 as ULK1-interacting proteins, suggests an Atg1 complex is involved in the induction of macroautophagy in mammalian cells.

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Journal ArticleDOI

BAR, F-BAR (EFC) and ENTH/ANTH domains in the regulation of membrane-cytosol interfaces and membrane curvature.

Toshiki Itoh, +1 more

- 01 Aug 2006 -

Biochimica et Biophysica Acta

TL;DR: A short overview of the properties of BAR and ENTH domains based on evidence obtained from genetics, cell biology, biochemistry and structural biology is presented.

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Journal ArticleDOI

WIPI-1alpha (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy

Tassula Proikas-Cezanne, +5 more

- 16 Dec 2004 -

Oncogene

TL;DR: The data suggest that WIPI proteins share an evolutionary conserved function in autophagy and that autophagic capacity may be compromised in human cancers.

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Journal ArticleDOI

Ammonia-induced autophagy is independent of ULK1/ULK2 kinases

Heesun Cheong, +4 more

- 05 Jul 2011 -

Proceedings of the National Academy of S...

TL;DR: It is found that autophagy induction upon glucose deprivation correlated with a rise in cellular ammonia levels caused by elevated amino acid catabolism, suggesting that cells with a mechanism to adapt not only to nitrogen deprivation but also to nitrogen excess.

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