Autophagosome formation--the role of ULK1 and Beclin1-PI3KC3 complexes in setting the stage.

doi:10.1016/J.SEMCANCER.2013.05.007

Journal ArticleDOI

Autophagosome formation--the role of ULK1 and Beclin1-PI3KC3 complexes in setting the stage.

Martina Wirth, +2 more

- 01 Oct 2013 -

Seminars in Cancer Biology

- Vol. 23, Iss: 5, pp 301-309

TLDR

How the mammalian ULK1 and Beclin1 complexes are controlled by post-translational modifications and protein-protein interactions is discussed and data linking these complexes together is highlighted.

About:

This article is published in Seminars in Cancer Biology.The article was published on 2013-10-01. It has received 218 citations till now. The article focuses on the topics: Autophagy.

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The autophagosome: origins unknown, biogenesis complex

Christopher A. Lamb, +2 more

- 01 Dec 2013 -

Nature Reviews Molecular Cell Biology

TL;DR: It is proposed that the isolation membrane forms from the mitochondria-associated endoplasmic reticulum (ER) membrane (MAM) and the role of ATG proteins and the vesicular trafficking machinery in autophagosome formation is proposed.

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Journal ArticleDOI

WIPI2 Links LC3 Conjugation with PI3P, Autophagosome Formation, and Pathogen Clearance by Recruiting Atg12–5-16L1

Hannah C. Dooley, +5 more

- 17 Jul 2014 -

Molecular Cell

TL;DR: Mutation experiments and ectopic localization of WIPI2b to plasma membrane show that WIPi2b is a PtdIns(3)P effector upstream of Atg16L1 and is required for LC3 conjugation and starvation-induced autophagy through recruitment of the Atg12–5- 16L1 complex.

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Journal ArticleDOI

To Be or Not to Be? How Selective Autophagy and Cell Death Govern Cell Fate

Douglas R. Green, +1 more

- 27 Mar 2014 -

Cell

TL;DR: The progress that has been made in the last few decades in determining the fates of damaged organelles and damaged cells through discrete, but genetically overlapping, pathways involving the selective autophagy and cell death machinery is considered.

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mTORC1 signaling and the metabolic control of cell growth.

Issam Ben-Sahra, +1 more

- 01 Apr 2017 -

Current Opinion in Cell Biology

TL;DR: As dysregulated mTORC1 underlies a variety of human diseases, including cancer, diabetes, autoimmune diseases, and neurological disorders, understanding the metabolic program downstream of m TORC1 provides insights into its role in these pathological states.

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References

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Journal ArticleDOI

ATG8 family proteins act as scaffolds for assembly of the ULK complex: sequence requirements for LC3-interacting region (LIR) motifs

Endalkachew Ashenafi Alemu, +9 more

- 16 Nov 2012 -

Journal of Biological Chemistry

TL;DR: ATG8 family proteins act as scaffolds anchoring the ULK complex on autophagosomes, and the LIR motif is required for starvation-induced association of ULK1 with autophagy, in addition to the known requirements of the aromatic and hydrophobic residues of the core motif.

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Journal ArticleDOI

Control of autophagy initiation by phosphoinositide 3-phosphatase jumpy

Isabelle Vergne, +7 more

- 05 Aug 2009 -

The EMBO Journal

TL;DR: This work reports for the first time that initiation of autophagy is controlled not only by the forward reaction of generating PI3P through a lipid kinase but that its levels are controlled by a specificPI3P phosphatase, which when defective can lead to human disease.

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Journal ArticleDOI

Autophagosome targeting and membrane curvature sensing by Barkor/Atg14(L)

Weiliang Fan, +2 more

- 10 May 2011 -

Proceedings of the National Academy of S...

TL;DR: A novel model of PI3KC3 autophagosome membrane nucleation is proposed in which its autophagy-specific adaptor, Barkor, accumulates on highly curved PtdIns(3)P enriched autophagic membrane via its BATS domain to sense and maintain membrane curvature.

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