scispace - formally typeset
Journal ArticleDOI

Autophagosome formation--the role of ULK1 and Beclin1-PI3KC3 complexes in setting the stage.

Martina Wirth, +2 more
- 01 Oct 2013 - 
- Vol. 23, Iss: 5, pp 301-309
TLDR
How the mammalian ULK1 and Beclin1 complexes are controlled by post-translational modifications and protein-protein interactions is discussed and data linking these complexes together is highlighted.
About: 
This article is published in Seminars in Cancer Biology.The article was published on 2013-10-01. It has received 218 citations till now. The article focuses on the topics: Autophagy.

read more

Citations
More filters
Journal ArticleDOI

The autophagosome: origins unknown, biogenesis complex

Christopher A. Lamb, +2 more
- 01 Dec 2013 - 
TL;DR: It is proposed that the isolation membrane forms from the mitochondria-associated endoplasmic reticulum (ER) membrane (MAM) and the role of ATG proteins and the vesicular trafficking machinery in autophagosome formation is proposed.
Journal Article

Global Analysis of Protein Phosphorylation in Yeast

Jason Ptacek, +24 more
- 01 Mar 2006 - 
TL;DR: The in vitro substrates recognized by most yeast protein kinases are described, with the use of proteome chip technology, and these results will provide insights into the mechanisms and roles of protein phosphorylation in many eukaryotes.
Journal ArticleDOI

WIPI2 Links LC3 Conjugation with PI3P, Autophagosome Formation, and Pathogen Clearance by Recruiting Atg12–5-16L1

Hannah C. Dooley, +5 more
- 17 Jul 2014 - 
TL;DR: Mutation experiments and ectopic localization of WIPI2b to plasma membrane show that WIPi2b is a PtdIns(3)P effector upstream of Atg16L1 and is required for LC3 conjugation and starvation-induced autophagy through recruitment of the Atg12–5- 16L1 complex.
Journal ArticleDOI

To Be or Not to Be? How Selective Autophagy and Cell Death Govern Cell Fate

Douglas R. Green, +1 more
- 27 Mar 2014 - 
TL;DR: The progress that has been made in the last few decades in determining the fates of damaged organelles and damaged cells through discrete, but genetically overlapping, pathways involving the selective autophagy and cell death machinery is considered.
Journal ArticleDOI

mTORC1 signaling and the metabolic control of cell growth.

Issam Ben-Sahra, +1 more
- 01 Apr 2017 - 
TL;DR: As dysregulated mTORC1 underlies a variety of human diseases, including cancer, diabetes, autoimmune diseases, and neurological disorders, understanding the metabolic program downstream of m TORC1 provides insights into its role in these pathological states.
References
More filters
Journal ArticleDOI

Imperfect interface of Beclin1 coiled-coil domain regulates homodimer and heterodimer formation with Atg14L and UVRAG

Xiaohua Li, +8 more
- 07 Feb 2012 - 
TL;DR: The results suggest that specific utilization of the dimer interface and modulation of the homodimer–heterodimer transition by Beclin 1-interacting partners may underlie the molecular mechanism that controls the formation of various BeClin1–VPS34 subcomplexes to exert their effect on an array of VPS34-related activities, including autophagy.
Journal ArticleDOI

The Three Musketeers of Autophagy: phosphorylation, ubiquitylation and acetylation.

David G. McEwan, +1 more
- 01 Apr 2011 - 
TL;DR: It is proposed that three types of post-translational modifications - phosphorylation, ubiquitylation and acetylation - are crucial for autophagy induction, regulation and fine-tuning, and are influenced by a variety of stimuli.
Journal ArticleDOI

Interaction of the Unc-51-like kinase and microtubule-associated protein light chain 3 related proteins in the brain: possible role of vesicular transport in axonal elongation.

Noriko Okazaki, +7 more
- 28 Dec 2000 - 
TL;DR: The results suggest that the interaction of ULK1 and GABARAP is important to vesicle transport and axonal elongation in mammalian neurons.
Journal ArticleDOI

Regulation of nutrient-sensitive autophagy by uncoordinated 51-like kinases 1 and 2.

Fiona E. Mcalpine, +3 more
- 04 Jan 2013 - 
TL;DR: These findings support functional redundancy between ULK1 and ULK2 for nutrient-dependent activation of autophagy and furthermore highlight the differential pathways that respond to amino acid and glucose deprivation.
Journal ArticleDOI

Nedd4-dependent lysine-11-linked polyubiquitination of the tumour suppressor Beclin 1

Harald W. Platta, +3 more
- 01 Jan 2012 - 
TL;DR: A regulatory link between Beclin 1 and the ubiquitin ligase Nedd4 (neural-precursor-cell-expressed developmentally down-regulated 4) is described, which is the first tumour suppressor reported to be controlled by Lys11-linked polyubiquitination.
Related Papers (5)

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

Joungmok Kim, +3 more
- 01 Feb 2011 - 

Autophagy: Renovation of Cells and Tissues

Noboru Mizushima, +1 more
- 11 Nov 2011 - 

Guidelines for the use and interpretation of assays for monitoring autophagy

Daniel J. Klionsky, +1287 more
- 01 Apr 2012 - 

Autophagy in human health and disease.

Augustine M.K. Choi, +2 more
- 13 Feb 2013 - 

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

Daniel F. Egan, +16 more
- 28 Jan 2011 -