Autophagosome formation--the role of ULK1 and Beclin1-PI3KC3 complexes in setting the stage.

doi:10.1016/J.SEMCANCER.2013.05.007

Journal ArticleDOI

Autophagosome formation--the role of ULK1 and Beclin1-PI3KC3 complexes in setting the stage.

Martina Wirth, +2 more

- 01 Oct 2013 -

Seminars in Cancer Biology

- Vol. 23, Iss: 5, pp 301-309

TLDR

How the mammalian ULK1 and Beclin1 complexes are controlled by post-translational modifications and protein-protein interactions is discussed and data linking these complexes together is highlighted.

About:

This article is published in Seminars in Cancer Biology.The article was published on 2013-10-01. It has received 218 citations till now. The article focuses on the topics: Autophagy.

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HMGB1-mediated autophagy confers resistance to gemcitabine in hormone-independent prostate cancer cells.

Yi Xiang Zhang, +5 more

- 01 Nov 2017 -

Oncology Letters

TL;DR: A new mechanism for the resistance to gemcitabine in HIPC cell lines is demonstrated, suggesting that inhibition of HMGB1 increased the sensitivity to gem citabine by decreasing autophagy response in HIPc cells.

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Routes to cell death in animal and plant kingdoms: from classic apoptosis to alternative ways to die—a review

Sonia Emanuele, +6 more

- 03 May 2018 -

Rendiconti Lincei-scienze Fisiche E Natu...

TL;DR: Non-apoptotic forms of cell death are best characterized in animals, whereas, in plants, the literature is less extensive, but the molecular executioners of plant cellDeath are becoming clearer.

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Journal ArticleDOI

TLR9 in MAFLD and NASH: At the Intersection of Inflammation and Metabolism.

Christopher R. Shepard

- 29 Jan 2021 -

Frontiers in Endocrinology

TL;DR: Toll-like Receptor 9 (TLR9) is an ancient receptor integral to the primordial functions of inflammation and metabolism and it functions to regulate homeostasis in a healthy system under acute stress.

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An oasis in the desert of cancer chemotherapeutic resistance: The enlightenment from reciprocal crosstalk between signaling pathways of UPR and autophagy in cancers.

Yuhang Zhang, +2 more

- 01 Aug 2017 -

Biomedicine & Pharmacotherapy

TL;DR: The link between UPR and autophagy has been verified as the PERK-eIF2α-ATF4 signaling pathway, and the transcription factor C/EBP homologous mediated by ATF4 were further substantiated to regulate a dozen of ATG genes transcriptionally.

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Journal ArticleDOI

Cardiac glycosides inhibit cancer through Na/K-ATPase-dependent cell death induction.

Xinran Geng, +10 more

- 22 Sep 2020 -

Biochemical Pharmacology

TL;DR: Analysis of the anticancer effects of a panel of 68 naturally isolated cardiac glycosides reveals sequential activation of autophagy and apoptosis during early stages of cardiac Glycoside treatment and indicates the importance of Na/K-ATPase in their anticancers effects.

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References

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mTOR Signaling in Growth Control and Disease

Mathieu Laplante, +1 more

TL;DR: The mechanistic target of rapamycin (mTOR) signaling pathway senses and integrates a variety of environmental cues to regulate organismal growth and homeostasis as mentioned in this paper, and is implicated in an increasing number of pathological conditions, including cancer, obesity, type 2 diabetes, and neurodegeneration.

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Journal ArticleDOI

Autophagy fights disease through cellular self-digestion

Noboru Mizushima, +3 more

- 28 Feb 2008 -

Nature

TL;DR: Understanding autophagy may ultimately allow scientists and clinicians to harness this process for the purpose of improving human health, and to play a role in cell death.

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Journal ArticleDOI

mTOR signaling in growth control and disease.

Mathieu Laplante, +1 more

- 13 Apr 2012 -

Cell

TL;DR: Recent advances in understanding of the mTOR pathway are reviewed and pharmacological approaches to treat human pathologies linked to mTOR deregulation are discussed.

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Journal ArticleDOI

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

Joungmok Kim, +3 more

- 01 Feb 2011 -

Nature Cell Biology

TL;DR: A molecular mechanism for regulation of the mammalian autophagy-initiating kinase Ulk1, a homologue of yeast ATG1, is demonstrated and a signalling mechanism for UlK1 regulation and autophagic induction in response to nutrient signalling is revealed.

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Journal ArticleDOI

TSC2 mediates cellular energy response to control cell growth and survival.

Ken Inoki, +2 more

- 26 Nov 2003 -

Cell

TL;DR: It is described that TSC2 is regulated by cellular energy levels and plays an essential role in the cellular energy response pathway and its phosphorylation by AMPK protect cells from energy deprivation-induced apoptosis.

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