Autophagosome formation--the role of ULK1 and Beclin1-PI3KC3 complexes in setting the stage.

doi:10.1016/J.SEMCANCER.2013.05.007

Journal ArticleDOI

Autophagosome formation--the role of ULK1 and Beclin1-PI3KC3 complexes in setting the stage.

Martina Wirth, +2 more

- 01 Oct 2013 -

Seminars in Cancer Biology

- Vol. 23, Iss: 5, pp 301-309

TLDR

How the mammalian ULK1 and Beclin1 complexes are controlled by post-translational modifications and protein-protein interactions is discussed and data linking these complexes together is highlighted.

About:

This article is published in Seminars in Cancer Biology.The article was published on 2013-10-01. It has received 218 citations till now. The article focuses on the topics: Autophagy.

Citations

PDF

Open Access

More filters

Journal ArticleDOI

Autophagy and microRNA in hepatitis B virus-related hepatocellular carcinoma.

Shan Ying Wu, +2 more

- 07 Jan 2016 -

World Journal of Gastroenterology

TL;DR: The accumulating knowledge pertaining to autophagy and miRNAs in HBV replication and its pathogenesis may lead to the development of novel strategies against HBV infection and HBV-related HCC tumorigenesis.

...read moreread less

Journal ArticleDOI

The STING controlled cytosolic-DNA activated innate immune pathway and microbial disease

Hiroyasu Konno, +1 more

- 01 Dec 2014 -

Microbes and Infection

TL;DR: The STING pathway has now been shown to be critical for activating innate immune gene transcription in response to infection by DNA pathogens such as herpes simplex virus 1 (HSV1) as well as retroviruses, and it is clear that chronic STING activation can also cause autoinflammatory disease manifested by self-DNA.

...read moreread less

Journal ArticleDOI

A cell-penetrating ester of the neural metabolite lanthionine ketimine stimulates autophagy through the mTORC1 pathway: Evidence for a mechanism of action with pharmacological implications for neurodegenerative pathologies

Marni E. Harris-White, +7 more

- 01 Dec 2015 -

Neurobiology of Disease

TL;DR: It is reported that a cell-penetrating neurotrophic and neuroprotective derivative of the central nervous system (CNS) metabolite, lanthionine ketimine (LK), stimulates autophagy in RG2 glioma and SH-SY5Y neuroblastoma cells at concentrations within or below pharmacological levels reported in previous mouse studies.

...read moreread less

Journal ArticleDOI

Saturated hydrogen saline ameliorates lipopolysaccharide-induced acute lung injury by reducing excessive autophagy (Review)

Yiming Liu, +1 more

- 01 Jun 2017 -

Experimental and Therapeutic Medicine

TL;DR: Saturated hydrogen saline may alleviate LPS-induced ALI by inhibiting autophagy, however its underlying mechanisms of action remain unknown, and signaling pathways involving heme oxygenase-1 and p38 mitogen-activated protein kinase are associated with the alleviative effects of saturated hydrogen saline on L PS-induced Autophagy.

...read moreread less

Journal ArticleDOI

Upregulation of ATG3 contributes to autophagy induced by the detachment of intestinal epithelial cells from the extracellular matrix, but promotes autophagy-independent apoptosis of the attached cells

Byong Hoon Yoo, +7 more

- 10 Jun 2015 -

Autophagy

TL;DR: It is observed that those few adherent cells that do not die by apoptosis induced by ATG3 become resistant to apoptosis caused by cell detachment, a property that is critical for the ability of normal epithelial cells to become malignant.

...read moreread less

Collapse

References

PDF

Open Access

More filters

mTOR Signaling in Growth Control and Disease

Mathieu Laplante, +1 more

TL;DR: The mechanistic target of rapamycin (mTOR) signaling pathway senses and integrates a variety of environmental cues to regulate organismal growth and homeostasis as mentioned in this paper, and is implicated in an increasing number of pathological conditions, including cancer, obesity, type 2 diabetes, and neurodegeneration.

...read moreread less

Journal ArticleDOI

Autophagy fights disease through cellular self-digestion

Noboru Mizushima, +3 more

- 28 Feb 2008 -

Nature

TL;DR: Understanding autophagy may ultimately allow scientists and clinicians to harness this process for the purpose of improving human health, and to play a role in cell death.

...read moreread less

Journal ArticleDOI

mTOR signaling in growth control and disease.

Mathieu Laplante, +1 more

- 13 Apr 2012 -

Cell

TL;DR: Recent advances in understanding of the mTOR pathway are reviewed and pharmacological approaches to treat human pathologies linked to mTOR deregulation are discussed.

...read moreread less

Journal ArticleDOI

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

Joungmok Kim, +3 more

- 01 Feb 2011 -

Nature Cell Biology

TL;DR: A molecular mechanism for regulation of the mammalian autophagy-initiating kinase Ulk1, a homologue of yeast ATG1, is demonstrated and a signalling mechanism for UlK1 regulation and autophagic induction in response to nutrient signalling is revealed.

...read moreread less

Journal ArticleDOI

TSC2 mediates cellular energy response to control cell growth and survival.

Ken Inoki, +2 more

- 26 Nov 2003 -

Cell

TL;DR: It is described that TSC2 is regulated by cellular energy levels and plays an essential role in the cellular energy response pathway and its phosphorylation by AMPK protect cells from energy deprivation-induced apoptosis.

...read moreread less