Autophagosome formation--the role of ULK1 and Beclin1-PI3KC3 complexes in setting the stage.

doi:10.1016/J.SEMCANCER.2013.05.007

Journal ArticleDOI

Autophagosome formation--the role of ULK1 and Beclin1-PI3KC3 complexes in setting the stage.

Martina Wirth, +2 more

- 01 Oct 2013 -

Seminars in Cancer Biology

- Vol. 23, Iss: 5, pp 301-309

TLDR

How the mammalian ULK1 and Beclin1 complexes are controlled by post-translational modifications and protein-protein interactions is discussed and data linking these complexes together is highlighted.

About:

This article is published in Seminars in Cancer Biology.The article was published on 2013-10-01. It has received 218 citations till now. The article focuses on the topics: Autophagy.

Citations

PDF

Open Access

More filters

Journal ArticleDOI

IGF-I and IGFBP-2 Stimulate AMPK Activation and Autophagy, Which Are Required for Osteoblast Differentiation

Gang Xi, +2 more

- 01 Jan 2016 -

Endocrinology

TL;DR: Early induction of AMPK in response to IGF-I/IGFBP-2 followed by suppression is required for osteoblast differentiation and down-regulation of these components may be required for induction of glycolysis, which is required during the final anabolic stages of differentiation.

...read moreread less

Journal ArticleDOI

The CD63-Syntenin-1 Complex Controls Post-Endocytic Trafficking of Oncogenic Human Papillomaviruses

Linda Gräßel, +11 more

- 31 Aug 2016 -

Scientific Reports

TL;DR: The results identify the CD63-syntenin-1-ALIX complex as a key regulatory component in post-endocytic HPV trafficking, and infectivity of high-risk HPV types 16, 18 and 31 as well as disassembly and post-uncoating processing of viral particles was markedly suppressed in CD63 or synten in-1 depleted cells.

...read moreread less

Journal ArticleDOI

HIF-1α/Beclin1-Mediated Autophagy Is Involved in Neuroprotection Induced by Hypoxic Preconditioning

Na Lu, +9 more

- 10 Sep 2018 -

Journal of Molecular Neuroscience

TL;DR: HPC protects SH-SY5Y cells against oxygen-glucose deprivation/reperfusion (OGD/R) via HIF-1α/Beclin1-regulated autophagy, and this hypothesis is demonstrated to be correct.

...read moreread less

Book ChapterDOI

AMPK Regulation of Cell Growth, Apoptosis, Autophagy, and Bioenergetics.

Marina Villanueva-Paz, +9 more

- 01 Jan 2016 -

Experientia. Supplementum

TL;DR: This chapter reviews the essential role of AMPK in signaling pathways that respond to cellular stress and damage, highlighting the complex and reciprocal regulation between AMPK and their targets and effectors.

...read moreread less

Journal ArticleDOI

mTOR independent regulation of macroautophagy by Leucine Rich Repeat Kinase 2 via Beclin-1.

Claudia Manzoni, +11 more

- 12 Oct 2016 -

Scientific Reports

TL;DR: Chemical inhibition of LRRK2 kinase activity resulted in the stimulation of macroautophagy in a non-canonical fashion, independent of mTOR and ULK1, but dependent upon the activation of Beclin 1-containing class III PI3-kinase.

...read moreread less

Collapse

References

PDF

Open Access

More filters

mTOR Signaling in Growth Control and Disease

Mathieu Laplante, +1 more

TL;DR: The mechanistic target of rapamycin (mTOR) signaling pathway senses and integrates a variety of environmental cues to regulate organismal growth and homeostasis as mentioned in this paper, and is implicated in an increasing number of pathological conditions, including cancer, obesity, type 2 diabetes, and neurodegeneration.

...read moreread less

Journal ArticleDOI

Autophagy fights disease through cellular self-digestion

Noboru Mizushima, +3 more

- 28 Feb 2008 -

Nature

TL;DR: Understanding autophagy may ultimately allow scientists and clinicians to harness this process for the purpose of improving human health, and to play a role in cell death.

...read moreread less

Journal ArticleDOI

mTOR signaling in growth control and disease.

Mathieu Laplante, +1 more

- 13 Apr 2012 -

Cell

TL;DR: Recent advances in understanding of the mTOR pathway are reviewed and pharmacological approaches to treat human pathologies linked to mTOR deregulation are discussed.

...read moreread less

Journal ArticleDOI

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

Joungmok Kim, +3 more

- 01 Feb 2011 -

Nature Cell Biology

TL;DR: A molecular mechanism for regulation of the mammalian autophagy-initiating kinase Ulk1, a homologue of yeast ATG1, is demonstrated and a signalling mechanism for UlK1 regulation and autophagic induction in response to nutrient signalling is revealed.

...read moreread less

Journal ArticleDOI

TSC2 mediates cellular energy response to control cell growth and survival.

Ken Inoki, +2 more

- 26 Nov 2003 -

Cell

TL;DR: It is described that TSC2 is regulated by cellular energy levels and plays an essential role in the cellular energy response pathway and its phosphorylation by AMPK protect cells from energy deprivation-induced apoptosis.

...read moreread less