Autophagosome formation--the role of ULK1 and Beclin1-PI3KC3 complexes in setting the stage.

doi:10.1016/J.SEMCANCER.2013.05.007

Journal ArticleDOI

Autophagosome formation--the role of ULK1 and Beclin1-PI3KC3 complexes in setting the stage.

Martina Wirth, +2 more

- 01 Oct 2013 -

Seminars in Cancer Biology

- Vol. 23, Iss: 5, pp 301-309

TLDR

How the mammalian ULK1 and Beclin1 complexes are controlled by post-translational modifications and protein-protein interactions is discussed and data linking these complexes together is highlighted.

About:

This article is published in Seminars in Cancer Biology.The article was published on 2013-10-01. It has received 218 citations till now. The article focuses on the topics: Autophagy.

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A model-driven methodology for exploring complex disease comorbidities applied to autism spectrum disorder and inflammatory bowel disease

Judith Somekh, +10 more

- 01 Oct 2016 -

Journal of Biomedical Informatics

TL;DR: The proposed Comparative Comorbidities Simulation method suggests that two LoF mutations previously implicated in IBD may contribute to ASD, and one ASD-implicated LoF mutation may play a role in I BD.

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Altered expression of mTOR and autophagy in term normal human placentas.

Qiu Xia Zhang, +2 more

- 01 Jan 2017 -

Romanian Journal of Morphology and Embry...

TL;DR: It is demonstrated that altered expression of mTOR and autophagy may be associated with the development of placentas and pathophysiology of FGR, and that there may be a reciprocal regulation between m TOR and Autophagy in human placenta.

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Rapamycin enhances growth inhibition on urothelial carcinoma cells through LKB1 deficiency‐mediated mitochondrial dysregulation

Young Mi Whang, +6 more

- 01 Aug 2019 -

Journal of Cellular Physiology

TL;DR: The findings suggest that the absence of LKB1 can be targeted to induce dysregulated mitochondrial biogenesis by rapamycin treatment in the design of novel therapeutic strategies for bladder cancer.

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Epigenetic inactivation of the autophagy-lysosomal system in appendix in Parkinson's disease.

Juozas Gordevičius, +21 more

- 26 Aug 2021 -

Nature Communications

TL;DR: In this article, the authors examined epigenetic alterations in the autophagy-lysosome pathway (ALP) in the appendix by deep sequencing DNA methylation at 521 ALP genes.

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Chemical screen identifies shikonin as a broad DNA damage response inhibitor that enhances chemotherapy through inhibiting ATM and ATR

Fangfang Wang, +10 more

- 28 Aug 2021 -

Acta Pharmaceutica Sinica B

TL;DR: Novel findings reveal shikonin as a pan DDR inhibitor and identify ATM as a primary factor in determining the chemo sensitizing effect of shik onin through inducing ATM degradation.

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References

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mTOR Signaling in Growth Control and Disease

Mathieu Laplante, +1 more

TL;DR: The mechanistic target of rapamycin (mTOR) signaling pathway senses and integrates a variety of environmental cues to regulate organismal growth and homeostasis as mentioned in this paper, and is implicated in an increasing number of pathological conditions, including cancer, obesity, type 2 diabetes, and neurodegeneration.

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Autophagy fights disease through cellular self-digestion

Noboru Mizushima, +3 more

- 28 Feb 2008 -

Nature

TL;DR: Understanding autophagy may ultimately allow scientists and clinicians to harness this process for the purpose of improving human health, and to play a role in cell death.

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mTOR signaling in growth control and disease.

Mathieu Laplante, +1 more

- 13 Apr 2012 -

Cell

TL;DR: Recent advances in understanding of the mTOR pathway are reviewed and pharmacological approaches to treat human pathologies linked to mTOR deregulation are discussed.

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Journal ArticleDOI

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

Joungmok Kim, +3 more

- 01 Feb 2011 -

Nature Cell Biology

TL;DR: A molecular mechanism for regulation of the mammalian autophagy-initiating kinase Ulk1, a homologue of yeast ATG1, is demonstrated and a signalling mechanism for UlK1 regulation and autophagic induction in response to nutrient signalling is revealed.

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TSC2 mediates cellular energy response to control cell growth and survival.

Ken Inoki, +2 more

- 26 Nov 2003 -

Cell

TL;DR: It is described that TSC2 is regulated by cellular energy levels and plays an essential role in the cellular energy response pathway and its phosphorylation by AMPK protect cells from energy deprivation-induced apoptosis.

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