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Joëlle Botti

Researcher at University of Paris

Publications -  28
Citations -  6313

Joëlle Botti is an academic researcher from University of Paris. The author has contributed to research in topics: Autophagy & Programmed cell death. The author has an hindex of 13, co-authored 27 publications receiving 5776 citations. Previous affiliations of Joëlle Botti include Paris Descartes University & University of Paris-Sud.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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Regulation of Autophagy by Sphingosine Kinase 1 and Its Role in Cell Survival during Nutrient Starvation

Grégory Lavieu, +9 more
- 31 Mar 2006 - 
TL;DR: Results show that SK1(S1P)-induced autophagy protects cells from death with apoptotic features during nutrient starvation, and is characterized by the inhibition of mammalian target of rapamycin signaling independently of the Akt/protein kinase B signaling arm.
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Autophagy signaling and the cogwheels of cancer.

Joëlle Botti, +3 more
- 25 Jan 2006 - 
TL;DR: Findings give credibility to the idea that autophagy is a tumor suppressor mechanism and suggest that cancer cells sometimes mobilize autophagic capacities in response to various stimuli without a fatal outcome, suggesting that they can also exploit macroautophagy for their own benefit.
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Autophagy: A Druggable Process.

Etienne Morel, +6 more
- 06 Jan 2017 - 
TL;DR: Each of these levels of regulation of autophagy in mammalian cells is potentially druggable, and, depending on the indication, may be able to stimulate or inhibit autophagosome maturation and lysosomal degradation.
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Legionella pneumophila S1P-lyase targets host sphingolipid metabolism and restrains autophagy.

Monica Rolando, +33 more
- 16 Feb 2016 - 
TL;DR: The crystal structure of one of the effector proteins, sphingosine-1 phosphate lyase (LpSpl), is determined, and it is demonstrated that it has high similarity with its eukaryotic homologue, and that it disrupts sphingolipid metabolism in the host cells.