Eli Arama

TL;DR: The Parkinson's disease-associated mitochondrial protease, HtrA2/Omi, is identified as an important mediator of GCD, acting mainly through its catalytic activity rather than by antagonizing inhibitor of apoptosis proteins.

TL;DR: A novel pathway of cell death in the ovary is revealed that utilizes strica, dronc, dcp-1 and drice, and importantly illustrates strong redundancy among the caspases, which indicates that caspase are required for nurse cell death during mid-oogenesis, and participate in developmental nurse cellDeath during late oogenesis.

TL;DR: A role of Cyt c in caspase regulation of Drosophila somatic cells is indicated and it is found that cyt c‐d—as with ark and dronc—regulates scutellar bristle number, which is known to depend on caspases activity.

TL;DR: Soti, an inhibitor of the Cullin-3-based E3 ubiquitin ligase complex required for caspase activation during Drosophila spermatid terminal differentiation (individualization), is identified and elucidate how the spatial regulation of caspases activation can permit casp enzyme-dependent differentiation while preventing full-blown apoptosis.