Roberto Mateo

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: The discovery that AP1 and AP2 cotraffic with HCV particles in live cells is discovered and a proof of principle for a repurposed, host-targeted approach to combat emerging viruses is established.

TL;DR: It is found that exogenous deoxycytidine markedly reduces GSK983 cytotoxicity but not antiviral activity, providing an attractive novel approach to improve the therapeutic window of DHODH inhibitors against RNA viruses.

TL;DR: It is concluded that the presence of functional autophagy components facilitates viral RNA replication and, more importantly, is required for infectious dengue virus production.

TL;DR: The results of the present study show, in fact, that virion thermostability against dissociation into subunits may not be selectively constrained by functional requirements for infectivity.