Saveria Aquila

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: Ligand-dependent or cell-autonomous activation of the TGF-β pathway in stromal cells induces their metabolic reprogramming, with increased oxidative stress, autophagy/mitophagy and glycolysis, and downregulation of Cav-1, and establishes a clear causative link between the tumor-promoting effects of T GF-β signaling and the metabolicReprogramming of the tumor microenvironment.

TL;DR: The concomitant expression of ER beta and ER alpha in human ejaculated spermatozoa is demonstrated and a different interaction of the two ERs with the PI3K/Akt pathway is provided, for the first time, because ER alpha interacts with the p55 regulatory subunit ofPI3K, whereas ER beta interacts with Akt1.

TL;DR: The data show for the first time that ERα binds to PPAR response element and represses its transactivation, and this crosstalk between ERα and PPARγ pathways in breast cancer cells could be taken into account in setting new pharmacologic strategies for breast cancer disease.

TL;DR: The data may suggest that ligand-activated EGFR could contribute to the failure of tamoxifen therapy also by up-regulating GPR30, which in turn could facilitates the action of estrogen.