Denis Mottet

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: Hypoxia or cobalt chloride, a chemical inducer of HIF‐1, could influence apoptosis induced by tert‐butyl hydroperoxide (t‐BHP), serum deprivation, or both in hepatoma cell line HepG2 and different data suggest a possible antiapoptotic role of Hif‐1.

TL;DR: Data identified HDAC7 as a key modulator of endothelial cell migration and hence angiogenesis, at least in part, by regulating PDGF-B/PDGFR-&bgr; gene expression, which may represent a rational target for therapeutic intervention against cancer.

TL;DR: A comprehensive overview of the role and the involvement of HDAC in carcinogenesis as well as the current progress on the development ofHDAC general and specific inhibitors as new cancer therapies is given.

TL;DR: The data indicating that ERK and JNK are needed for activation of HIF‐1 and AP‐1, respectively are summarized.