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Julia I-Ju Leu

Researcher at University of Pennsylvania

Publications -  33
Citations -  6706

Julia I-Ju Leu is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Liver regeneration & Gene. The author has an hindex of 17, co-authored 30 publications receiving 6015 citations. Previous affiliations of Julia I-Ju Leu include Raymond and Ruth Perelman School of Medicine at the University of Pennsylvania.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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An African-specific polymorphism in the TP53 gene impairs p53 tumor suppressor function in a mouse model

Matthew Jennis, +17 more
- 15 Apr 2016 - 
TL;DR: The S47 variant exhibits a modest decrease in apoptosis in response to most genotoxic stresses compared with wild-type p53 but exhibits a significant defect in cell death induced by cisplatin, and the potential relevance of metabolism and ferroptosis to tumor suppression by p53 is confirmed.
Journal ArticleDOI

Interleukin-6-induced STAT3 and AP-1 amplify hepatocyte nuclear factor 1-mediated transactivation of hepatic genes, an adaptive response to liver injury.

Julia I-Ju Leu, +4 more
- 15 Jan 2001 - 
TL;DR: The results demonstrate that the two classes of transcription factors, growth induced (STAT3 and AP-1) and tissue specific (HNF-1), can interact as an adaptive response to liver injury to amplify expression of hepatic genes important for the homeostatic response during organ repair.
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Massive hepatic apoptosis associated with TGF-β1 activation after Fas ligand treatment of IGF binding protein-1–deficient mice

Julia I-Ju Leu, +2 more
- 01 Jan 2003 - 
TL;DR: Findings indicate that IGFBP-1 functions as a critical hepatic survival factor in the liver by reducing the level of proapoptotic signals.
Journal ArticleDOI

Impaired Hepatocyte DNA Synthetic Response Posthepatectomy in Insulin-Like Growth Factor Binding Protein 1-Deficient Mice with Defects in C/EBPβ and Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Regulation

Julia I-Ju Leu, +3 more
- 15 Feb 2003 - 
TL;DR: The first demonstration of the involvement of IGFBP-1 in the regulation of in vivo mitogenic signaling pathways is demonstrated, suggesting that IGF BP-1 may support liver regeneration at least in part via its effect on MAPK/ERK and C/EBPβ activities.