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Derrick Gibbings

Researcher at University of Ottawa

Publications -  26
Citations -  7362

Derrick Gibbings is an academic researcher from University of Ottawa. The author has contributed to research in topics: Autophagy & RNA. The author has an hindex of 16, co-authored 23 publications receiving 6608 citations. Previous affiliations of Derrick Gibbings include École Polytechnique Fédérale de Lausanne & University of Strasbourg.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Journal ArticleDOI

Multivesicular bodies associate with components of miRNA effector complexes and modulate miRNA activity

Derrick Gibbings, +3 more
- 16 Aug 2009 - 
TL;DR: It is proposed that this process promotes continuous assembly or disassembly of membrane-associated miRISCs, which is possibly required for miRNA loading or target recognition and subsequent silencing.
Journal ArticleDOI

Selective autophagy degrades DICER and AGO2 and regulates miRNA activity

Derrick Gibbings, +7 more
- 01 Dec 2012 - 
TL;DR: It is shown that the DICER enzyme and the main miRNA effector, AGO2, are targeted for degradation as miRNA-free entities by the selective autophagy receptor NDP52, underscoring the importance of fine-tuned regulation of the miRNA pathway.
Journal ArticleDOI

Atg5 Disassociates the V1V0-ATPase to Promote Exosome Production and Tumor Metastasis Independent of Canonical Macroautophagy

Huishan Guo, +18 more
- 18 Dec 2017 - 
TL;DR: It is demonstrated that exosome production is strongly reduced in cells lacking Atg5 and Atg16L1, but this is independent of Atg7 and canonical autophagy, and mechanisms controlling exosomes release are uncovered.
Journal ArticleDOI

Autophagy supports genomic stability by degrading retrotransposon RNA

Huishan Guo, +6 more
- 04 Nov 2014 - 
TL;DR: Autophagy physiologically buffers genetic variegation by degrading retrotransposon RNA, which may contribute to the increased tumorigenesis occuring when autophagy is inhibited and suggest a role for autophagic in tempering evolutionary change.