Rossella Menghini

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: The data pinpoint miR-217 as an endogenous inhibitor of SirT1, which promotes endothelial senescence and is potentially amenable to therapeutic manipulation for prevention of endothelial dysfunction in metabolic disorders.

TL;DR: The data show that hyperglycemia impairs activation of the IR/IRS/PI3-K/Akt pathway, resulting in deregulation of eNOS activity, and carotid plaques from type 2 diabetic patients showed increased endothelial O-GlcNAcylation with respect to nondiabetics.

TL;DR: A miR-146a is identified that is progressively modulated in endothelial cells with aging and involved in a premature senescence-like phenotype through direct targeting of the NOX4 protein, implicated in cellsenescence and aging.

TL;DR: A novel interaction between insulin action and control of inflammation is reported, resulting in glucose intolerance and vascular inflammation and amenable to therapeutic modulation, suggesting that an interplay between reduced insulinaction and unchecked TACE activity promotes diabetes and vascularinflammation.