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Shibu M. Poulose

Researcher at Tufts University

Publications -  45
Citations -  7530

Shibu M. Poulose is an academic researcher from Tufts University. The author has contributed to research in topics: Oxidative stress & Autophagy. The author has an hindex of 25, co-authored 45 publications receiving 6776 citations. Previous affiliations of Shibu M. Poulose include Icahn School of Medicine at Mount Sinai & United States Department of Agriculture.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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Disrupted Autophagy Leads to Dopaminergic Axon and Dendrite Degeneration and Promotes Presynaptic Accumulation of α-Synuclein and LRRK2 in the Brain

Lauren G. Friedman, +7 more
- 30 May 2012 - 
TL;DR: It is suggested that disrupted autophagy may be associated with enhanced levels of endogenous α-syn and LRRK2 proteins in vivo, and implicate dysfunctional Autophagy as one of the failing cellular mechanisms involved in the pathogenesis of idiopathic PD.
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Leucine-rich repeat kinase 2 (LRRK2)/PARK8 possesses GTPase activity that is altered in familial Parkinson's disease R1441C/G mutants.

Xianting Li, +5 more
- 01 Oct 2007 - 
TL;DR: This study produced and purified the epitope‐tagged LRRK2 protein from transgenic mouse brain, and showed that purified brain LRRk2 possesses both kinase and GTPase activity as assayed by GTP binding and hydrolysis.
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Anthocyanin-rich Açai (Euterpe oleracea Mart.) Fruit Pulp Fractions Attenuate Inflammatory Stress Signaling in Mouse Brain BV-2 Microglial Cells

Shibu M. Poulose, +7 more
- 20 Jan 2012 - 
TL;DR: The protection of microglial cells by açai pulp extracts was also accompanied by a significant concentration-dependent reduction in cyclooxygenase-2, p38 mitogen-activated protein kinase (p38-MAPK), tumor necrosis factor-α (TNFα), and nuclear factor κB (NF-κB).
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Citrus Limonoids Induce Apoptosis in Human Neuroblastoma Cells and Have Radical Scavenging Activity

Shibu M. Poulose, +3 more
- 01 Apr 2005 - 
TL;DR: It is concluded that citrus limonoid glucosides are toxic to SH-SY5Y cancer cells, and this difference may reside in structural variations in the A ring of the limonoids molecule.