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Alberto Bartolomé

Researcher at Columbia University

Publications -  35
Citations -  7384

Alberto Bartolomé is an academic researcher from Columbia University. The author has contributed to research in topics: mTORC1 & Autophagy. The author has an hindex of 17, co-authored 29 publications receiving 5779 citations. Previous affiliations of Alberto Bartolomé include Columbia University Medical Center & Complutense University of Madrid.

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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Daniel J. Klionsky, +2983 more
- 08 Feb 2021 - 
TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.
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Hepatocyte Notch activation induces liver fibrosis in nonalcoholic steatohepatitis

Changyu Zhu, +14 more
- 21 Nov 2018 - 
TL;DR: It is reported that hepatocyte Notch activity tracks with disease severity and treatment response in patients with NASH and is similarly increased in a mouse model of diet-induced NASh and liver fibrosis, and a Notch inhibitor was developed that reduced fibrosis in NASH diet–fed mice.
Journal ArticleDOI

Pancreatic β-Cell Failure Mediated by mTORC1 Hyperactivity and Autophagic Impairment

Alberto Bartolomé, +14 more
- 01 Sep 2014 - 
TL;DR: Evidence of β-cell autophagy impairment is provided as a link between mTORC1 hyperactivation and mitochondrial dysfunction that probably contributes to β- cell failure.
Journal ArticleDOI

Autophagy Plays a Protective Role in Endoplasmic Reticulum Stress-Mediated Pancreatic β Cell Death

Alberto Bartolomé, +2 more
- 05 Sep 2012 - 
TL;DR: It is shown how the autophagic response plays a prosurvival role in β cells may be contributing to ER stress-mediated cell death, and in this regard, rapamycin treatment increased both autophagy and cell survival under ER stress.