Daniela De Zio

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.

TL;DR: This work finds a non-apoptotic baseline caspase-3 activity in hippocampal dendritic spines and an enhancement of this activity at the onset of memory decline in the Tg2576-APPswe mouse model of Alzheimer's disease, and identifies a previously unknown casp enzyme-3–dependent mechanism that drives synaptic failure and contributes to cognitive dysfunction in Alzheimer's Disease.

TL;DR: It is demonstrated that kaempferol, but not quercetin, myricetin or resveratrol, protects SH-SY5Y cells and primary neurons from rotenone toxicity, as a reduction of caspases cleavage and apoptotic nuclei are observed.

TL;DR: It is shown that the scaffold protein AMBRA1 regulates cell proliferation by facilitating the dephosphorylation and degradation of the proto-oncogene c-Myc and that, when mTOR is inhibited, it enhances PP2A activity on this specific target, thereby reducing the cell division rate.