Shaun Martin

TL;DR: The various aspects of necroptosis immunobiology are discussed with specific focus on immuno-oncology and cancer immunotherapy.

TL;DR: Melphalan administration in vivo could stimulate a CD8(+) T cell-dependent protective antitumor response and was potentiated in combination with exogenous calreticulin, but not tumor necrosis factor, a cytokine often combined with Mel-ILP.

TL;DR: The N-terminal binding of PA and PI(3,5)P2 emerges as a key to unlock the activity of ATP13A2 and thereby reduce α-synuclein toxicity or mitochondrial stress in PD or related disorders.

TL;DR: An autophagy-driven response that relies on the secretion of ATP to drive P2RX7-based migration and expansion of the Vemurafenib-resistant phenotype is identified, emphasizing the potential of targeting autophagic capacity in the treatment and management of metastatic melanoma.