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Sergey Leikin

Researcher at National Institutes of Health

Publications -  96
Citations -  7562

Sergey Leikin is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Type I collagen & Osteogenesis imperfecta. The author has an hindex of 45, co-authored 92 publications receiving 6109 citations. Previous affiliations of Sergey Leikin include University of Maryland, Baltimore & Russian Academy of Sciences.

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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Daniel J. Klionsky, +2983 more
- 08 Feb 2021 - 
TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.
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Type I collagen is thermally unstable at body temperature.

E. Leikina, +3 more
- 05 Feb 2002 - 
TL;DR: The data support an earlier hypothesis that in fibers collagen helices may melt and refold locally when needed, giving fibers their strength and elasticity and argue that initial microunfolding of their least stable domains would trigger self-assembly of fibers where the helices are protected from complete unfolding.
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Prolyl 3-hydroxylase 1 deficiency causes a recessive metabolic bone disorder resembling lethal/severe osteogenesis imperfecta

Wayne A. Cabral, +14 more
- 04 Feb 2007 - 
TL;DR: The first five cases of a new recessive bone disorder resulting from null LEPRE1 alleles are presented; its phenotype overlaps with lethal/severe osteogenesis imperfecta but has distinctive features and a mutant allele from West Africa occurs in four of five cases.
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Deficiency of Cartilage-Associated Protein in Recessive Lethal Osteogenesis Imperfecta

Aileen M. Barnes, +16 more
- 28 Dec 2006 - 
TL;DR: Three of 10 children with lethal or severe osteogenesis imperfecta were found to have a recessive condition resulting in CRTAP deficiency, suggesting that prolyl 3-hydroxylation of type I collagen is important for bone formation.
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Structure and interactions of biological helices

Alexei A. Kornyshev, +3 more
- 06 Aug 2007 - 
TL;DR: The present article focuses on the most important and interesting aspects of the physics of structured macromolecules, highlighting various manifestations of the helical motif in their structure, elasticity, interactions with counterions, aggregation, and polyand mesomorphic transitions.