Shail K. Chaube

TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.

TL;DR: Balance between level of ROS and antioxidants within the ovary are important for maintenance of female reproductive health and reduce ROS levels and protect against OS-mediated germ cell apoptosis and thereby depletion of germ cells from the Ovary.

TL;DR: Oocyte apoptosis leads to the depletion of ovarian reserve that directly affects reproductive outcome of various mammals including human.

TL;DR: The maturation promoting factor, cytostatic factors, and spindle assembly checkpoint proteins are also involved in that maintenance of arrest at various stages of meiotic cell cycle in mammalian oocytes.

TL;DR: It is suggested that H2O2 induced GVBD in immature oocytes, inhibited first polar body extrusion in mature oocytes prior to initiation of morphological changes characteristic of apoptosis such as shrinkage, membrane blebbing and cytoplasmic fragmentation prior to degeneration.