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David Sebastián

Researcher at Spanish National Research Council

Publications -  149
Citations -  7896

David Sebastián is an academic researcher from Spanish National Research Council. The author has contributed to research in topics: Catalysis & Carbon nanofiber. The author has an hindex of 39, co-authored 139 publications receiving 5595 citations. Previous affiliations of David Sebastián include University of Barcelona & Carlos III Health Institute.

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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Daniel J. Klionsky, +2983 more
- 08 Feb 2021 - 
TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.
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Mitofusin 2 (Mfn2) links mitochondrial and endoplasmic reticulum function with insulin signaling and is essential for normal glucose homeostasis

David Sebastián, +14 more
- 03 Apr 2012 - 
TL;DR: This study provides an important description of a unique unexpected role of Mfn2 coordinating mitochondria and endoplasmic reticulum function, leading to modulation of insulin signaling and glucose homeostasis in vivo.
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Mitofusin 2 in POMC Neurons Connects ER Stress with Leptin Resistance and Energy Imbalance

Marc Schneeberger, +16 more
- 26 Sep 2013 - 
TL;DR: It is shown that mitochondria-ER contacts in anorexigenic pro-opiomelanocortin neurons in the hypothalamus are decreased in diet-induced obesity, establishing MFN2 in POMC neurons as an essential regulator of systemic energy balance by fine-tuning the mitochondrial-ER axis homeostasis and function.
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Mfn2 modulates the UPR and mitochondrial function via repression of PERK.

Juan Pablo Muñoz, +21 more
- 28 Aug 2013 - 
TL;DR: The data indicate that Mfn2 is an upstream modulator of PERK, and Mfn1 loss‐of‐function reveals that PERK is a key regulator of mitochondrial morphology and function.
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Mfn2 deficiency links age-related sarcopenia and impaired autophagy to activation of an adaptive mitophagy pathway

David Sebastián, +24 more
- 01 Aug 2016 - 
TL;DR: The findings reveal that Mfn2 repression in muscle during aging is a determinant for the inhibition of mitophagy and accumulation of damaged mitochondria and triggers the induction of a mitochondrial quality control pathway.