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Open AccessJournal ArticleDOI

Enteroviral Infection Inhibits Autophagic Flux via Disruption of the SNARE Complex to Enhance Viral Replication

Yasir Mohamud, +9 more
- 20 Mar 2018 - 
- Vol. 22, Iss: 12, pp 3292-3303
TLDR
This study reveals a mechanism that supports an emerging model whereby CVB3 hijacks the autophagic machinery to facilitate its own propagation, and demonstrates that loss of SNAP29/PLEKHM1 inhibits Autophagic flux, resulting in increased viral replication.
About: 
This article is published in Cell Reports.The article was published on 2018-03-20 and is currently open access. It has received 86 citations till now. The article focuses on the topics: Signal transducing adaptor protein & Endosome.

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Citations
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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Daniel J. Klionsky, +2983 more
- 08 Feb 2021 - 
TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.
Journal ArticleDOI

Autophagy-Independent Functions of the Autophagy Machinery

Lorenzo Galluzzi, +1 more
- 13 Jun 2019 - 
TL;DR: Emerging data on the non-autophagic functions of autophagy-relevant proteins is discussed and it is suggested that most, if not all, components of the molecular machinery for Autophagy also mediate autophagic-independent functions.
Journal ArticleDOI

ORF3a of the COVID-19 virus SARS-CoV-2 blocks HOPS complex-mediated assembly of the SNARE complex required for autolysosome formation.

Guangyan Miao, +8 more
- 22 Feb 2021 - 
TL;DR: The study reveals a mechanism by which SARS-CoV-2 evades lysosomal destruction and provides insights for developing new strategies to treat COVID-19 and Surprisingly, ORF3a from the SARS virus SARS -CoV fails to interact with HOPS or block autophagy.
Journal ArticleDOI

Machinery, regulation and pathophysiological implications of autophagosome maturation

Yan G Zhao, +2 more
- 23 Jul 2021 - 
TL;DR: In this paper, the authors discuss the recent progress in understanding of the machinery and regulation of autophagosome maturation, the relevance of these mechanisms to human pathophysiology and how they are harnessed by pathogens for their benefit.
Book ChapterDOI

Autophagy and Viral Infection.

Jingrong Mao, +5 more
- 01 Jan 2019 - 
TL;DR: This chapter illustrates how autophagy prevents viral infection to generate an optimal anti-viral milieu, and focuses on how viruses subvert and hijack the autophagic process to evade immunosurveillance, thereby facilitating viral replication and pathogenesis.
References
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Journal ArticleDOI

Dissection of the Autophagosome Maturation Process by a Novel Reporter Protein, Tandem Fluorescent-Tagged LC3

Shunsuke Kimura, +2 more
- 25 May 2007 - 
TL;DR: Using this method, evidence that overexpression of a dominant negative form of Rab7 prevented the fusion of autophagosomes with lysosomes is provided, suggesting that Rab7 is involved in this step.
Journal ArticleDOI

The Hairpin-type Tail-Anchored SNARE Syntaxin 17 Targets to Autophagosomes for Fusion with Endosomes/Lysosomes

Eisuke Itakura, +2 more
- 07 Dec 2012 - 
TL;DR: This work identifies syntaxin 17 (Stx17) as the autophagosomal SNARE required for fusion with the endosome/lysosome, and reveals a mechanism by which the SNARE protein is available to the completed Autophagosome.
Journal ArticleDOI

Subversion of cellular autophagosomal machinery by RNA viruses.

William T. Jackson, +6 more
- 26 Apr 2005 - 
TL;DR: It is argued that these double-membraned structures provide membranous supports for viral RNA replication complexes, possibly enabling the nonlytic release of cytoplasmic contents, including progeny virions, from infected cells.
Journal ArticleDOI

Regulation of starvation- and virus-induced autophagy by the eIF2α kinase signaling pathway

Zsolt Tallóczy, +7 more
- 08 Jan 2002 - 
TL;DR: Autophagy is a novel evolutionarily conserved function of the eIF2α kinase pathway that is targeted by viral virulence gene products.
Journal ArticleDOI

Modification of intracellular membrane structures for virus replication

Sven Miller, +1 more
- 01 May 2008 - 
TL;DR: How viruses modify intracellular membranes is described, similarities between the structures that are induced by viruses of different families are highlighted and how these structures could be formed are discussed.
Related Papers (5)

Subversion of cellular autophagosomal machinery by RNA viruses.

William T. Jackson, +6 more
- 26 Apr 2005 - 

Autophagosome Supports Coxsackievirus B3 Replication in Host Cells

Jerry Wong, +6 more
- 15 Sep 2008 - 

Phosphatidylserine Vesicles Enable Efficient En Bloc Transmission of Enteroviruses

Ying-Han Chen, +13 more
- 12 Feb 2015 - 

Coxsackievirus B exits the host cell in shed microvesicles displaying autophagosomal markers.

Scott M. Robinson, +19 more
- 10 Apr 2014 - 

Nonlytic viral spread enhanced by autophagy components

Sara W. Bird, +3 more
- 09 Sep 2014 -